Central Michigan vs. Buffalo Prediction, Odds, Picks - November 12, 2025

Updated Nov. 12, 2025 3:06 p.m. ET

FOX Sports

MAC foes meet when the Central Michigan Chippewas (5-4) host the Buffalo Bulls (5-4) on Wednesday, November 12, 2025 at Kelly/Shorts Stadium. Central Michigan is favored by 2 points. The over/under is 44 in this game.

In their last game, the Chippewas lost against the Western Michigan Broncos, 24-21. The Bulls' last game was against the Bowling Green Falcons, and they won by a score of 28-3.

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Central Michigan vs. Buffalo Game Information & Odds

When: Wednesday, November 12, 2025 at 7 p.m. ET
Location: Kelly/Shorts Stadium in Mount Pleasant, Michigan
TV: CBS Sports Network
Live Box Score on FOX Sports

Central Michigan vs Buffalo Betting Information updated as of November 12, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Central Michigan	-2 (-111)	-130	+109	44	-110	-110

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Central Michigan vs. Buffalo Prediction

Pick ATS: Central Michigan (-2)
Pick OU: Over (44)
Prediction: Central Michigan 26, Buffalo 19

Predictions are made by the Data Skrive betting model.

Learn more about the Central Michigan Chippewas vs. the Buffalo Bulls game on FOX Sports!

Central Michigan vs. Buffalo Betting Insights

Per the spread and over/under, the implied score for the game is Chippewas 23, Bulls 21.
The Chippewas have a 56.5% chance to claim victory in this meeting per the moneyline's implied probability. The Bulls have a 47.8% implied probability.
Central Michigan has compiled a 6-3-0 ATS record so far this year.
Buffalo has won three games against the spread this year, failing to cover or pushing six times.

Central Michigan vs. Buffalo: Head-to-Head

In their past two matchups, Buffalo holds a split 1-1 record against Central Michigan.
The Chippewas and the Bulls have matched up evenly over their last two meetings, holding an even 1-1 record against the spread. In those two games, the two squads have eclipsed the over on the total on one occasion.
Central Michigan has been outscored by 20 points in its last two tilts against Buffalo.

Central Michigan vs. Buffalo: 2025 Stats Comparison

	Central Michigan	Buffalo
Off. Points per Game (Rank)	24.1 (100)	24.8 (94)
Def. Points per Game (Rank)	24 (60)	19.6 (22)
Turnovers Allowed (Rank)	8 (14)	13 (86)
Turnovers Forced (Rank)	13 (43)	10 (85)

Central Michigan 2025 Key Players

Name	Position	Stats
Angel Flores	QB	195 YDS (70.4%) / 2 TD / 0 INT 519 RUSH YDS / 8 RUSH TD / 64.9 RUSH YPG
Nahree Biggins	RB	426 YDS / 2 TD / 47.3 YPG / 5.3 YPC 15 REC / 158 REC YDS / 1 REC TD / 22.6 REC YPG
Brock Townsend	RB	288 YDS / 2 TD / 36 YPG / 5.4 YPC 9 REC / 134 REC YDS / 3 REC TD / 19.1 REC YPG
Joey Labas	QB	1,066 YDS (71.6%) / 8 TD / 2 INT
Jordan Kwiatkowski	LB	60 TKL / 2 TFL / 0.5 SACK / 2 INT
Dakota Cochran	LB	51 TKL / 1 TFL / 0.5 SACK / 1 INT
Michael Heldman	DL	31 TKL / 4 TFL / 5.5 SACK
Jaion Jackson	DB	25 TKL / 2 TFL / 2 SACK / 1 INT

Buffalo 2025 Key Players

Name	Position	Stats
Ta'Quan Roberson	QB	1,739 YDS (60.5%) / 12 TD / 8 INT 159 RUSH YDS / 2 RUSH TD / 19.9 RUSH YPG
Victor Snow	WR	45 REC / 586 YDS / 7 TD / 65.1 YPG
Al-Jay Henderson	RB	663 YDS / 5 TD / 73.7 YPG / 4.1 YPC 25 REC / 181 REC YDS / 1 REC TD / 22.6 REC YPG
Nik McMillan	WR	41 REC / 584 YDS / 1 TD / 64.9 YPG
Khalil Murdock	LB	95 TKL / 7 TFL / 4.5 SACK
Dion Crawford	LB	55 TKL / 3 TFL / 2.5 SACK
Mitchell Gonser	LB	45 TKL / 2 TFL / 1 SACK / 1 INT
Kobe Stewart	DL	33 TKL / 3 TFL / 3 SACK