Arizona vs. Colorado Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 3:04 p.m. ET

FOX Sports

The Colorado Buffaloes (3-5) are 4-point underdogs in a home conference matchup against the Arizona Wildcats (4-3) on Saturday, November 1, 2025 at Folsom Field. The total for this matchup has been set at 52.5 points.

The Wildcats lost against the Houston Cougars in their most recent game, 31-28. The Buffaloes lost against the Utah Utes in their last game, 53-7.

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Arizona vs. Colorado Game Information & Odds

When: Saturday, November 1, 2025 at 7 p.m. ET
Location: Folsom Field in Boulder, Colorado
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Arizona vs Colorado Betting Information updated as of November 1, 2025, 1:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Arizona	-4 (-112)	-185	+153	52.5	-110	-111

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Arizona vs. Colorado Prediction

Pick ATS: Colorado (+4)
Pick OU: Under (52.5)
Prediction: Arizona 26, Colorado 25

Predictions are made by the Data Skrive betting model.

Learn more about the Arizona Wildcats vs. the Colorado Buffaloes game on FOX Sports!

Arizona vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the game is Wildcats 28, Buffaloes 24.
The Wildcats have a 64.9% chance to collect the win in this game based on the moneyline's implied probability. The Buffaloes have a 39.5% implied probability.
Arizona has put together a 3-3-0 ATS record so far this year.
Colorado has put together a 4-4-0 ATS record so far this year.

Arizona vs. Colorado: Head-to-Head

Arizona and Colorado have been matched up evenly over their last four meetings, sharing the same 2-2 record.
The Buffaloes carry a 3-1 record ATS in those games, while the two teams have gone over the total on two occasions.
Arizona has been outpaced by 35 points in its last four tilts versus Colorado.

Arizona vs. Colorado: 2025 Stats Comparison

	Arizona	Colorado
Off. Points per Game (Rank)	31.6 (69)	22.6 (101)
Def. Points per Game (Rank)	20.3 (24)	27.4 (92)
Turnovers Allowed (Rank)	8 (37)	9 (56)
Turnovers Forced (Rank)	13 (28)	6 (112)

Arizona 2025 Key Players

Name	Position	Stats
Noah Fifita	QB	1,829 YDS (66%) / 17 TD / 4 INT 78 RUSH YDS / 3 RUSH TD / 11.1 RUSH YPG
Ismail Mahdi	RB	445 YDS / 1 TD / 63.6 YPG / 5.8 YPC 11 REC / 79 REC YDS / 1 REC TD / 13.2 REC YPG
Tre Spivey	WR	10 REC / 223 YDS / 5 TD / 31.9 YPG
Jayin Whatley	WR	32 REC / 370 YDS / 3 TD / 52.9 YPG
Dalton Johnson	DB	39 TKL / 1 TFL / 1 SACK / 1 INT
Max Harris	LB	35 TKL / 1 TFL
Taye Brown	LB	37 TKL / 1 TFL / 1 INT / 1 PD
Genesis Smith	DB	27 TKL / 0 TFL / 1 INT / 4 PD

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	1,193 YDS (62.2%) / 9 TD / 5 INT 267 RUSH YDS / 5 RUSH TD / 38.1 RUSH YPG
Omarion Miller	WR	23 REC / 430 YDS / 4 TD / 61.4 YPG
Joseph Williams	WR	24 REC / 370 YDS / 3 TD / 52.9 YPG
Micah Welch	RB	281 YDS / 2 TD / 35.1 YPG / 4.1 YPC
Jeremiah Brown	LB	40 TKL / 5 TFL / 1 SACK
Tawfiq Byard	DB	40 TKL / 1 TFL / 0.5 SACK / 1 INT
Keaten Wade	DL	28 TKL / 4 TFL / 2.5 SACK
D.J. McKinney	DB	27 TKL / 1 TFL / 1 INT / 1 PD