Michigan State vs. Ole Miss Prediction, Odds, Picks - NCAA Tournament Sweet 16

Updated Mar. 28, 2025 3:27 p.m. ET

Data Skrive

A Sweet 16 matchup will feature the No. 2 seed Michigan State Spartans (29-6) and the No. 6 seed Ole Miss Rebels (24-11) playing on Friday at State Farm Arena. The NCAA Tournament contest begins at 7:09 p.m. ET.

The Spartans head into their game as a 3.5-point favorite against the Rebels. The game's point total is set at 144.5.

Continue scrolling to get all you need to know ahead of betting on the Michigan State-Ole Miss contest.

Michigan State vs. Ole Miss Game Information & Odds

When: Friday, March 28, 2025 at 7:09 p.m. ET
Where: State Farm Arena in Atlanta, Georgia
How to watch on TV: CBS
Live boxscore on FOX Sports

Spartans vs Rebels Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Spartans	-3.5	-110	-110	144.5	-110	-110	-180	+150

Michigan State vs. Ole Miss Prediction

Pick ATS: Michigan State (-3.5)
Pick OU: Over (144.5)
Prediction: Michigan State 75, Ole Miss 72

Learn more about the Michigan State Spartans vs. the Ole Miss Rebels game on FOX Sports!

Michigan State vs. Ole Miss Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the encounter is Spartans 74, Rebels 70.
The Spartans have a 64.3% chance to claim victory in this meeting based on the moneyline's implied probability.
The Rebels hold a 40.0% implied probability to win.

Key Spread Facts

Michigan State has won 23 games against the spread this season, while failing to cover or pushing 12 times.
Ole Miss has covered 18 times in 35 chances against the spread this season.
Michigan State is 17-8 ATS this season when playing as at least 3.5-point favorites.
Ole Miss is 6-4 ATS this year when playing as at least 3.5-point underdogs.

Key Total Facts

A total of 15 times so far this season, the Spartans and their opponent have combined to score more than 144.5 points.
Rebels games have gone over 144.5 points on 19 occasions this season.
These teams score 155.6 points per game combined, higher than the over/under for this matchup by 11.1.

Key Moneyline Facts

Michigan State has been favored on the moneyline 28 times this season. They've finished 24-4 in those games.
This season, Ole Miss has won seven out of the 16 games, or 43.8%, in which it has been the underdog.
When it has played as a moneyline favorite with odds of -180 or shorter, Michigan State has gone 21-3 (87.5% win percentage).
Ole Miss has a record of 2-6 when it is set as the underdog by +150 or more by oddsmakers this season.

Michigan State vs. Ole Miss: 2024-25 Stats Comparison

	Michigan State	Ole Miss
Points Scored Per Game (Rank)	78.2 (74)	77.4 (82)
Points Allowed (Rank)	67 (43)	71.7 (172)
Rebounds (Rank)	10.6 (50)	7.3 (308)
3pt Made (Rank)	6 (336)	8.3 (111)
Assists (Rank)	16.7 (21)	14.2 (125)
Turnovers (Rank)	10.8 (142)	8.7 (7)

Michigan State 2024-25 Key Players

Spartans Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Jaden Akins	35	12.7	3.5	1.5	0.8	0.3	1.5
Jase Richardson	34	11.9	3.2	2	0.8	0.3	1.3
Tre Holloman	35	9.3	1.9	3.7	0.9	0.3	1.4
Coen Carr	35	7.9	3.7	0.6	0.5	0.7	0.1
Jaxon Kohler	35	7.8	7.5	1.3	0.4	0.7	0.5

Ole Miss 2024-25 Key Players

Rebels Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Sean Pedulla	35	15.2	3.5	3.7	1.9	0.2	2.4
Jaemyn Brakefield	35	11.1	4.3	1.8	0.8	0.3	0.7
Malik Dia	35	10.7	5.7	0.8	0.7	0.9	0.8
Matthew Murrell	31	10.7	3.5	1.8	1.8	0.2	1.3
Jaylen Murray	35	10.5	2.2	3.5	1.4	0.2	1.7