Duke vs. Arizona Prediction, Odds, Picks - NCAA Tournament Sweet 16

Updated Mar. 27, 2025 8:27 p.m. ET

Data Skrive

The No. 4-seed Arizona Wildcats (24-12) are ready for a Sweet 16 matchup against the No. 1 Duke Blue Devils (33-3) on Thursday at 9:39 p.m. ET as the NCAA Tournament continues at Prudential Center airing on CBS.

The Blue Devils enter their matchup against the Wildcats as a 9.5-point favorite. The game's point total is set at 153.5.

Keep scrolling to get the details ahead of wagering on the Duke-Arizona clash.

Duke vs. Arizona Game Information & Odds

When: Thursday, March 27, 2025 at 9:39 p.m. ET
Where: Prudential Center in Newark, New Jersey
How to watch on TV: CBS
Live boxscore on FOX Sports

Blue Devils vs Wildcats Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Blue Devils	-9.5	-110	-110	153.5	-108	-112	-549	+410

Duke vs. Arizona Prediction

Pick ATS: Arizona (+9.5)
Pick OU: Under (153.5)
Prediction: Duke 79, Arizona 70

Learn more about the Duke Blue Devils vs. the Arizona Wildcats game on FOX Sports!

Duke vs. Arizona Betting Insights

Betting Line Implied Predictions

Per the spread and over/under, the implied score for the encounter is Blue Devils 82, Wildcats 72.
The Blue Devils have an 84.6% chance to claim victory in this contest based on the moneyline's implied probability.
The Wildcats sit with a 19.6% implied probability to win.

Key Spread Facts

Duke has compiled a 24-12-0 record against the spread this season.
Arizona has put together a 19-17-0 ATS record so far this year.
Duke has been favored by 9.5 points or more 26 times this season, and covered the spread in 18 of those matchups.

Key Total Facts

In 10 games this year, the Blue Devils and their opponent have combined to score more than 153.5 points.
Wildcats games have gone over 153.5 points on 20 occasions this year.
The total for this matchup is 153.5 points, 11.9 fewer than the combined scoring average of the two teams.

Key Moneyline Facts

Duke has gone 31-3 in games when it was favored on the moneyline (winning 91.2%).
Arizona has been underdogs in nine games this season and won four (44.4%) of those contests.
Duke has won all 24 games it played as a moneyline favorite with odds of -549 or shorter.
Arizona has not entered a game this season with longer moneyline odds than +410.

Duke vs. Arizona: Recent Results

Blue Devils vs Wildcats Recent Games
Date	Favorite	Spread	Total	Favorite Moneyline	Underdog Moneyline	Result
11/22/2024	Wildcats	-2	162.5	-122	+102	69-55 DUKE
11/10/2023	Blue Devils	-5.5	155.5	-238	+195	78-73 ARZ

Duke vs. Arizona: 2024-25 Stats Comparison

	Duke	Arizona
Points Scored Per Game (Rank)	83.2 (12)	82.2 (17)
Points Allowed (Rank)	61.7 (6)	72.5 (197)
Rebounds (Rank)	9.7 (111)	10.6 (51)
3pt Made (Rank)	10.3 (18)	7.1 (246)
Assists (Rank)	16.9 (16)	16.3 (28)
Turnovers (Rank)	8.9 (9)	11.3 (200)

Duke 2024-25 Key Players

Blue Devils Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Cooper Flagg	34	18.7	7.5	4.1	1.4	1.2	1.3
Kon Knueppel	36	14.1	3.9	2.7	1	0.2	2.1
Tyrese Proctor	35	12.5	3.1	2.3	0.9	0.1	2.5
Khaman Maluach	36	8.4	6.7	0.5	0.2	1.2	0.1
Sion James	36	8.4	4.1	3	0.9	0.3	0.8

Arizona 2024-25 Key Players

Wildcats Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Caleb Love	36	16.8	4.4	3.5	1.2	0.3	2.6
Jaden Bradley	36	12	3.4	3.6	1.8	0.1	0.7
KJ Lewis	36	10.9	4.6	2.9	1.3	0.9	0.4
Henri Veesaar	36	9.3	5	1.3	0.7	1.1	0.4
Trey Townsend	34	8.3	4	1	0.3	0.2	0.4