Isaac Guerendo - Page 2 - NFL News, Rumors, & Updates

Playing through shoulder inury Guerendo (shoulder) rushed the ball eight times for 13 yards in Saturday's 30-23 preseason win over the Chargers. He added one reception on one target for one yard.

Impact Guerendo started the game with Christian McCaffrey resting and Brian Robinson not yet officially with the team. Per Eric Branch of the San Francisco Chronicle, Guerendo appeared to aggravate the shoulder injury he suffered earlier in camp in the first quarter and was wearing a brace as protection. Positively, he was able to return to the game, so it appears as though he'll be available for San Francisco's Week 1 matchup against Seattle -- albeit with an unclear role.

AUGUST 24, 2025 • ROTOWIRE

49ers' trade for Brian Robinson is a damning indictment on Isaac Guerendo The second-year running back has shown flashes, but he is missing the most important ability.

AUGUST 23, 2025 • NINERNOISE.COM

49ers bolster injury-hit backfield by acquiring Brian Robinson from Washington

The San Francisco 49ers have acquired running back Brian Robinson from the Washington Commanders for a 2026 sixth-round draft pick

AUGUST 22, 2025 • Associated Press

Facing competition from Robinson Guerendo may open the season as San Francisco's No. 2 running back even though the team is trading for Brian Robinson, Cam Inman of The San Jose Mercury News reports.

Impact The 49ers presumably wouldn't trade for Robinson, even at the cost of just a sixth-round pick, unless they thought he could become their No. 2 running back. That doesn't mean he'll simply be handed the gig, however, nor does it mean he'll be comfortable with the playbook in time for Week 1 at Seattle. Still, the trade takes a chunk out of Guerendo's fantasy value, adding another legitimate competitor for backup roles after the Niners drafted Jordan James (finger) in the fifth round this spring. Guerendo is the fastest and most athletic of the bunch, but his injury history dating back to college is concerning, to say the least.

AUGUST 22, 2025 • ROTOWIRE

Tatum Bethune, Isaac Guerendo Reflect on Year Two Growth LB Tatum Bethune and RB Isaac Guerendo spoke on their personal growth entering their second NFL season, the impact of veteran mentorship, an...

AUGUST 21, 2025 • 49ERS.COM

49ers injury woes continue as key players return and others sidelined

The San Francisco 49ers have seen changes in their injury list as some key players return while others remain sidelined

AUGUST 19, 2025 • Associated Press

Returns to practice Guerendo (shoulder) participated in Tuesday's training camp practice, Nick Wagoner of ESPN.com reports.

Impact Guerendo suffered a shoulder injury in practice in early August, which caused him to miss the 49ers' two preseason games. He was back on the field Tuesday and was given the green light to participate in team drills, and Wagoner relays that Guerendo was heavily involved with the offense and on special teams as a kick returner. Barring any setbacks, the 2024 fourth-rounder is on track to be available for Saturday's preseason finale against the Chargers.

AUGUST 19, 2025 • ROTOWIRE

49ers suffer 3 more injuries on offense in preseason win over Raiders

The San Francisco 49ers lost starting right guard Dominic Puni and two other offensive players in the first half of their 22-19 preseason win over the Las Vegas Raiders

AUGUST 17, 2025 • Associated Press

Jake Moody wins 49ers' kicking competition for now after Greg Joseph is released

Jake Moody has won the San Francisco 49ers' kicking competition

AUGUST 4, 2025 • Associated Press

Out for a few weeks 49ers coach Kyle Shanahan said Monday that Guerendo (shoulder) is expected to miss a couple weeks, Matt Maiocco of NBC Sports Bay Area reports.

Impact Guerendo made an early exit from Saturday's practice and apparently won't be back for a while. It sounds like he has a shot to be ready for Week 1, but a preseason appearance probably isn't in the cards. Guerendo's absence could give rookie Jordan James more opportunities to mix in with the first-team offense, especially on days when Christian McCaffrey is rested.

AUGUST 4, 2025 • ROTOWIRE

Exits practice with apparent injury Guerendo had an early departure from practice Saturday due to an apparent shoulder injury, Jennifer Lee Chan of NBC Sports Bay Area reports.

Impact The possible injury occurred during special-teams drills. It's not yet clear how severe the issue may be, though that should become more evident once 49ers coach Kyle Shanahan chimes in and/or based on Guerendo's practice status in the days ahead. Guerendo is the favorite to work as San Francisco's No. 2 running back this season and should also see action as a kick returner.

AUGUST 2, 2025 • ROTOWIRE

Why Isaac Guerendo Could be the 49ers' Breakout Player this Year The 49ers need someone new to step up and become a factor on offense.

JULY 6, 2025 • SI.COM

Fantasy Football 2025: RB Isaac Guerendo player profile Nathan Jahnke breaks down San Francisco 49ers running back Isaac Guerendo's 2025 fantasy football player profile.

JUNE 17, 2025 • PFF.COM

On field for OTAs Guerendo (knee/ankle) was an active participant at voluntary OTAs, per the 49ers' official site.

Impact Guerendo sustained MCL and ankle sprains in his left leg during San Francisco's regular-season finale, but the 2024 fourth-round pick appears back to full health ahead of mandatory minicamp, which will take place June 10-11. Christian McCaffrey also looks fully healthy after having been limited to four appearances in 2024, which leaves Guerendo competing for No. 2 reps entering Year 2. The 49ers saw fit to trade Jordan Mason to Minnesota this offseason and let Elijah Mitchell link up with the Chiefs in free agency, though the team did re-sign Patrick Taylor and select Jordan James in the fifth round of the 2025 NFL Draft. Guerendo's athleticism and explosiveness makes him a high upside backup to McCaffrey, but injuries have been a consistent roadblock for him dating back to college.

JUNE 6, 2025 • ROTOWIRE

Ranking NFL Offenses: San Francisco 49ers No. 8 The San Francisco 49ers’ offense presents strong fantasy upside in 2025, with key players like Brock Purdy, Christian McCaffrey, and Brandon...

MAY 6, 2025 • THESTATE.COM

Notable 49ers Fourth-Round Draftees: Isaac Guerendo, Charles Haley, and More The San Francisco 49ers are scheduled to make two selections in the fourth round of the 2025 NFL Draft. Take a look at the team's history of...

APRIL 17, 2025 • 49ERS.COM

49ers seek to bolster depleted defense in NFL draft after string of offseason losses

A recent run of weak draft hauls and an exodus of talent this offseason has left the San Francisco 49ers in a different spot heading into this year’s draft

APRIL 14, 2025 • Associated Press

Will 49ers Running Back Isaac Guerendo Make a Big Leap in 2025? One of the 49ers’ most intriguing rookies last season was Isaac Guerendo. He didn’t play a ton -- just 222 offensive snaps to be exact. And...

APRIL 12, 2025 • NEWSOBSERVER.COM

Jennings, Guerendo Share a Glimpse of Their Offseason Grind | Off the Field San Francisco 49ers running back Isaac Guerendo trained alongside Jonathan Taylor and Frank Gore while wide receiver Jauan Jennings checked...

APRIL 11, 2025 • 49ERS.COM

Large Expectations Loom for 49ers RB Isaac Guerendo in 2025 The 49ers will need Isaac Guerendo to step up next year with Jordan Mason gone.

APRIL 2, 2025 • NEWSOBSERVER.COM

Isaac Guerendo's 2024 NFL Scouting Combine Workout San Francisco 49ers fourth-round draft pick, Louisville running back Isaac Guerendo, runs the 40-yard dash at the 2024 NFL Scouting Combine.

FEBRUARY 28, 2025 • 49ERS.COM

Has MCL, ankle sprains Guerendo has been diagnosed with MCL and ankle sprains in his left leg following an MRI on Monday, but he didn't damage the ACL in his left knee during Sunday's loss at Arizona, Ma...

Impact The 49ers' 2024 campaign is over, but the team's season finale included yet another RB injury. On only his second carry of Sunday's game, Guerendo had his left leg twisted under him as he was tackled, and he needed a cart to go to the locker room. He thus is one of four San Francisco running backs to enter the offseason focusing on rehab. The others are Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring). Guerendo, a 2024 fourth-round pick, proved to be effective when given the chance as a rookie, turning 84 carries into 420 yards (5.0 YPC) and four touchdowns and hauling in 15 of 16 targets for 152 yards in 16 appearances.

JANUARY 7, 2025 • ROTOWIRE

MCL sprain likely, tests upcoming Coach Kyle Shanahan said after Sunday's 47-24 loss to the Cardinals that Guerendo (knee/ankle) likely suffered an MCL sprain and will undergo further testing Monday, Lindsey Pallar...

Impact Guerendo suffered knee and ankle injuries, with the knee injury likely to be an MCL sprain. The results of Monday's tests should help provide clarification on the recovery timeline for Guerendo. The 49ers' season came to a close with Sunday's defeat in the regular-season finale.

JANUARY 6, 2025 • ROTOWIRE

Won't return Sunday Guerendo won't return to Sunday's game at Arizona due to knee and ankle injuries.

Impact Guerendo had his left leg twisted under him on his second carry of the game, and his teammates quickly motioned to the sideline for assistance. He eventually was carted off the field and ruled out not long after. With Guerendo unavailable, the 49ers will entrust the run game in Patrick Taylor and FB Kyle Juszczyk for the rest of their season finale.

JANUARY 5, 2025 • ROTOWIRE

Isaac Guerendo injury update and status vs. the Cardinals in Week 18 | Jan. 5, 2024 On Sunday at 4:25 PM ET at State Farm Stadium, Isaac Guerendo and the San Francisco 49ers square off against the Arizona Cardinals in Week 1...

JANUARY 4, 2025 • USATODAY.COM

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49ers bolster injury-hit backfield by acquiring Brian Robinson from Washington

49ers injury woes continue as key players return and others sidelined

49ers suffer 3 more injuries on offense in preseason win over Raiders

Jake Moody wins 49ers' kicking competition for now after Greg Joseph is released

49ers seek to bolster depleted defense in NFL draft after string of offseason losses