Isaac Guerendo - NFL News, Rumors, & Updates

49ers' 2024 breakout rusher is as good as gone after a brutal 2025 campaign After Isaac Guerendo had a strong 2024 campaign with the San Francisco 49ers, he was pushed out of the picture in 2025 which may seal his fa...

JANUARY 26 • NINERNOISE.COM

Falls out of favor in 2025 Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.

Impact Guerendo entered his sophomore campaign with an opportunity to serve as Christian McCaffrey's primary backup, but he failed to seize the role in training camp and the team opted to trade for veteran RB Brian Robison (92-400-2) to fill that role instead. The 25-year-old Guerendo averaged 5.0 yards per carry in his rookie season, so it was a bit surprising to see San Francisco's coaching staff give him zero carries in 2025. The Louisville product was healthy for the majority of the schedule and appeared in 14 games as a member of the special teams unit. Guerendo still has two years left on his rookie contract, but it doesn't appear that the 49ers view the running back as part of the team's long-term vision on offense.

JANUARY 8 • ROTOWIRE

49ers' Trent Williams and Ricky Pearsall miss crucial game against Seahawks with injuries

San Francisco 49ers Pro Bowl left tackle Trent Williams and receiver Ricky Pearsall missed the Week 18 game against the Seattle Seahawks due to injuries

JANUARY 4 • Associated Press

Healthy scratch again in Week 17 Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago.

Impact Guerendo will be a healthy scratch for the second straight week after having played in the team's previous 14 contests. Jordan James will get another nod as the 49ers' No. 3 running back behind Christian McCaffrey and Brian Robinson in Week 17.

DECEMBER 29, 2025 • ROTOWIRE

49ers' George Kittle misses key game against Bears with ankle injury

San Francisco star tight end George Kittle will miss the 49ers’ key game in playoff positioning on Sunday night against the Chicago Bears with an ankle injury

DECEMBER 29, 2025 • Associated Press

Breakout 49ers RB's days are numbered after rookie gets elevated It has been a tough season for 49ers second-year running back Isaac Guerendo.

DECEMBER 26, 2025 • NINERNOISE.COM

Colts activate Pro Bowl DT DeForest Buckner for a crucial Monday night game against the 49ers

Pro Bowl defensive tackle DeForest Buckner was activated off injured reserve and will play Monday night when the Indianapolis Colts face the San Francisco 49ers

DECEMBER 23, 2025 • Associated Press

Inactive for MNF Guerendo (coach's decision) is inactive for Monday night's game against the Colts.

Impact Guerendo has appeared in all 14 games this season leading up to Monday night, but rookie Jordan James is getting the nod over him against the Colts as the Niners' RB3 behind Christian McCaffrey and Brian Robinson. All of Guerendo's 173 snaps this season have come on special teams.

DECEMBER 22, 2025 • ROTOWIRE

Role remains marginalized Guerendo logged three snaps on special teams in Sunday's 37-24 win over the Titans.

Impact Guerendo remained a non-factor on offense behind Christian McCaffrey and Brian Robinson on San Francisco's running back depth chart. The 25-year-old Guerendo once returned kickoffs for the 49ers, but the team has removed him from that role completely since Week 5. Barring a string of catastrophic injuries in the backfield, Guerendo can safely be ignored during the fantasy playoffs.

DECEMBER 15, 2025 • ROTOWIRE

No run on offense this season Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans.

Impact As a rookie last season, Guerendo showcased some explosiveness out of the San Francisco backfield with averages of 5.0 yards per carry and 10.1 yards per reception over 16 games, but he has yet to play a snap on offense in the 49ers' first eight games of 2025. With lead back Christian McCaffrey having thus far stayed healthy while handling huge snap and touch counts each week, Brian Robinson has picked up the remaining scraps left over in the backfield. So long as McCaffrey and Robinson are able to avoid injury, Guerendo looks as though he'll be limited to a role on kickoff returns and kick-coverage units.

OCTOBER 29, 2025 • ROTOWIRE

Returns one kickoff Thursday Guerendo ran back one kickoff for 18 yards while receiving no carries or targets in Thursday's 26-23 overtime win over the Rams.

Impact Christian McCaffrey continued to operate as San Francisco's bell cow (88 percent) while Brian Robinson (14 percent) remained the clear No. 2, which leaves Guerendo parked in the garage when the team is on offense. The 2024 fourth-round selection is stuck on special teams for the foreseeable future, needing an injury to open up playing time ahead of him on the depth chart. Guerendo generates no fantasy value in his current role when the 49ers visit the Buccaneers in Week 6.

OCTOBER 3, 2025 • ROTOWIRE

Logs 14 snaps on special teams Guerendo logged 14 snaps on special teams and was not used on offense in Sunday's 26-21 loss to the Jaguars.

Impact Guerendo couldn't even make an appearance in the box score as a return man after WR Skyy Moore handled all punt and kick returns Sunday. The 25-year-old Guerendo has logged zero snaps on offense through four games this season, leaving no room for fantasy utility as we encroach the quarter point of the season. Managers should have no concerns leaving Guerendo in the free agent pool for Thursday's tilt against the Rams.

SEPTEMBER 29, 2025 • ROTOWIRE

Stuck on special teams Guerendo did not receive a carry while gaining 19 yards on a kickoff return in Sunday's 16-15 win over the Cardinals.

Impact Guerendo continued to be used exclusively on special teams, logging all 15 of his snaps there Sunday. Brian Robinson was the only running back to receive any carries outside of starter Christian McCaffrey. Guerendo carries no fantasy value heading into a Week 4 matchup against Jacksonville.

SEPTEMBER 22, 2025 • ROTOWIRE

49ers' 2024 breakout rookie has been completely iced out of rushing attack The 49ers' rushing attack has only featured two players, as 2024 breakout rookie Isaac Guerendo has been iced out of the backfield.

SEPTEMBER 15, 2025 • NINERNOISE.COM

No carries in Week 2 win Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.

Impact Guerendo failed to see the field on offense Sunday, logging all 17 of his snaps on special teams. Veteran backup Brian Robinson continues to handle all of the touches starter Christian McCaffrey doesn't gobble up on game days. More of the same can be expected against the Cardinals in Week 3, leaving Guerendo off the fantasy radar until an injury opens up playing time for the sophomore.

SEPTEMBER 15, 2025 • ROTOWIRE

Limited to special teams Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks.

Impact The good news for Guerendo was that he was fully cleared from the shoulder injury that limited him in camp. That bad news for the sophomore tailback is that new addition Brian Robinson usurped him on the depth chart. Guerendo dropped to third in the pecking order and was limited to special teams, returning one kickoff for 16 yards. In his current role, Guerendo provides no fantasy utility heading into next Sunday's tilt against the Saints.

SEPTEMBER 8, 2025 • ROTOWIRE

Kyle Shanahan Provides Injury Updates Ahead of Week 1 Matchup Head coach Kyle Shanahan addressed the media to discuss the latest on RB Christian McCaffrey's status and highlighted the progress of RB Isa...

SEPTEMBER 7, 2025 • 49ERS.COM

49ers star Christian McCaffrey questionable for season opener after calf injury

San Francisco 49ers star Christian McCaffrey is questionable for the season opener after injuring his calf at practice

SEPTEMBER 5, 2025 • Associated Press

Why the 49ers Gave up on Isaac Guerendo for Brian Robinson Jr. Kyle Shanahan opens up about Isaac Guerendo's status on the 49ers after acquiring Brian Robinson Jr..

SEPTEMBER 4, 2025 • THENEWSTRIBUNE.COM

Full practice Wednesday Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.

Impact Guerendo exited practice on Aug. 2 due to a shoulder injury and sat out the next two-and-a-half weeks, only to be healthy enough to play in the 49ers' preseason finale Aug. 23 and turn eight carries into 13 yards and one catch (on one target) into one yard. In the midst of it all, the team traded for Commanders RB Brian Robinson, placing Guerendo's status into question heading into Week 1. Even though Guerendo has a clean bill of health in advance of Sunday's contest at Seattle, he may play third fiddle out of San Francisco's backfield to starter Christian McCaffrey and Robinson.

SEPTEMBER 3, 2025 • ROTOWIRE

Isaac Guerendo's fantasy football value nosedives with 49ers' latest depth chart Fantasy football fans may have been eyeing the 49ers' Isaac Guerendo, but he's looking more like a wasted roster spot than anything else.

SEPTEMBER 3, 2025 • NINERNOISE.COM

Running back Brian Robinson joins 49ers seeking to form the 'best duo in the league' with McCaffrey

Brian Robinson has joined the San Francisco 49ers after a trade from the Washington Commanders

AUGUST 25, 2025 • Associated Press

Playing through shoulder inury Guerendo (shoulder) rushed the ball eight times for 13 yards in Saturday's 30-23 preseason win over the Chargers. He added one reception on one target for one yard.

Impact Guerendo started the game with Christian McCaffrey resting and Brian Robinson not yet officially with the team. Per Eric Branch of the San Francisco Chronicle, Guerendo appeared to aggravate the shoulder injury he suffered earlier in camp in the first quarter and was wearing a brace as protection. Positively, he was able to return to the game, so it appears as though he'll be available for San Francisco's Week 1 matchup against Seattle -- albeit with an unclear role.

AUGUST 24, 2025 • ROTOWIRE

49ers' trade for Brian Robinson is a damning indictment on Isaac Guerendo The second-year running back has shown flashes, but he is missing the most important ability.

AUGUST 23, 2025 • NINERNOISE.COM

49ers bolster injury-hit backfield by acquiring Brian Robinson from Washington

The San Francisco 49ers have acquired running back Brian Robinson from the Washington Commanders for a 2026 sixth-round draft pick

AUGUST 22, 2025 • Associated Press

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