ISAAC GUERENDO #31 - RUNNING BACK - SAN FRANCISCO 49ERS
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#31 - RUNNING BACK - SAN FRANCISCO 49ERS
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This Trade Offer is Too Good to be True for the 49ers The San Francisco 49ers are unlikely to get any trade offers for running back Isaac Guerendo
JUNE 3 • SI.COM
Isaac Guerendo might have cost himself a roster spot at 49ers OTAs Issac Guerendo might have cost himself a roster spot at organized team activities before training camp has fully begun.
JUNE 2 • NINERNOISE.COM
49ers RB Isaac Guerendo's injury news might be secret blessing in disguise Isaac Guerendo was dealt some bad injury news this offseason, but it might actually benefit his shaky tenure with the 49ers in the long run.
MAY 29 • NINERNOISE.COM

Nick Bosa Expects to Be 'On Track' for 49ers Season Opener Following Knee Surgery

Nick Bosa is encouraged by the pace of his recovery from another major knee surgery and believes he's on track to return to the field during...
MAY 29 • FOX SPORTS
Nick Bosa Expects to Be 'On Track' for 49ers Season Opener Following Knee Surgery
Dealing with torn pectoral Guerendo is not participating in OTAs due to a torn pectoral, Cam Inman of The San Jose Mercury News reports.
Impact The running back suffered the injury while lifting "about a month ago," per David Lombardi of SFStandard.com. Guerendo is expected back near the end of training camp, though he did already undergo surgery, per Jeremy Fowler of ESPN.com. The 2024 fourth-round pick did not receive a single carry in 2025 despite appearing in 14 regular-season games.
MAY 29 • ROTOWIRE
49ers RB Isaac Guerendo's Roster Spot in Jeopardy After Latest Injury This isn't the start that running back Isaac Guerendo wanted for OTAs. Kyle Shanahan revealed today that the third-year running back tore hi...
MAY 28 • SI.COM
Isaac Guerendo is now on thin ice after 49ers draft Kaelon Black The 49ers made it clear they don't trust Isaac Guerendo on the depth chart after selecting Kaelon Black in Round 3 of the NFL Draft.
APRIL 25 • NINERNOISE.COM
Why RB Isaac Guerendo is on Borrowed Time With the 49ers One of the reasons the San Francisco 49ers didn't ease up on Christian McCaffrey's workload last season was that they didn't have a running...
APRIL 4 • SI.COM
Under-the-radar 49ers signing likely seals the fate of 2 backup RBs The 49ers have retained running back Patrick Taylor Jr. which is not good news for free agent Brian Robinson Jr. or Isaac Guerendo.
MARCH 15 • NINERNOISE.COM
49ers' 2024 breakout rusher is as good as gone after a brutal 2025 campaign After Isaac Guerendo had a strong 2024 campaign with the San Francisco 49ers, he was pushed out of the picture in 2025 which may seal his fa...
JANUARY 26 • NINERNOISE.COM
Falls out of favor in 2025 Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.
Impact Guerendo entered his sophomore campaign with an opportunity to serve as Christian McCaffrey's primary backup, but he failed to seize the role in training camp and the team opted to trade for veteran RB Brian Robison (92-400-2) to fill that role instead. The 25-year-old Guerendo averaged 5.0 yards per carry in his rookie season, so it was a bit surprising to see San Francisco's coaching staff give him zero carries in 2025. The Louisville product was healthy for the majority of the schedule and appeared in 14 games as a member of the special teams unit. Guerendo still has two years left on his rookie contract, but it doesn't appear that the 49ers view the running back as part of the team's long-term vision on offense.
JANUARY 8 • ROTOWIRE

49ers' Trent Williams and Ricky Pearsall miss crucial game against Seahawks with injuries

San Francisco 49ers Pro Bowl left tackle Trent Williams and receiver Ricky Pearsall missed the Week 18 game against the Seattle Seahawks due to injuries
JANUARY 4 • Associated Press
Healthy scratch again in Week 17 Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago.
Impact Guerendo will be a healthy scratch for the second straight week after having played in the team's previous 14 contests. Jordan James will get another nod as the 49ers' No. 3 running back behind Christian McCaffrey and Brian Robinson in Week 17.
DECEMBER 29, 2025 • ROTOWIRE

49ers' George Kittle misses key game against Bears with ankle injury

San Francisco star tight end George Kittle will miss the 49ers’ key game in playoff positioning on Sunday night against the Chicago Bears with an ankle injury
DECEMBER 29, 2025 • Associated Press
Breakout 49ers RB's days are numbered after rookie gets elevated It has been a tough season for 49ers second-year running back Isaac Guerendo.
DECEMBER 26, 2025 • NINERNOISE.COM

Colts activate Pro Bowl DT DeForest Buckner for a crucial Monday night game against the 49ers

Pro Bowl defensive tackle DeForest Buckner was activated off injured reserve and will play Monday night when the Indianapolis Colts face the San Francisco 49ers
DECEMBER 23, 2025 • Associated Press
Inactive for MNF Guerendo (coach's decision) is inactive for Monday night's game against the Colts.
Impact Guerendo has appeared in all 14 games this season leading up to Monday night, but rookie Jordan James is getting the nod over him against the Colts as the Niners' RB3 behind Christian McCaffrey and Brian Robinson. All of Guerendo's 173 snaps this season have come on special teams.
DECEMBER 22, 2025 • ROTOWIRE
Role remains marginalized Guerendo logged three snaps on special teams in Sunday's 37-24 win over the Titans.
Impact Guerendo remained a non-factor on offense behind Christian McCaffrey and Brian Robinson on San Francisco's running back depth chart. The 25-year-old Guerendo once returned kickoffs for the 49ers, but the team has removed him from that role completely since Week 5. Barring a string of catastrophic injuries in the backfield, Guerendo can safely be ignored during the fantasy playoffs.
DECEMBER 15, 2025 • ROTOWIRE
No run on offense this season Guerendo played all 10 of his snaps on special teams in Sunday's 26-15 loss to the Texans.
Impact As a rookie last season, Guerendo showcased some explosiveness out of the San Francisco backfield with averages of 5.0 yards per carry and 10.1 yards per reception over 16 games, but he has yet to play a snap on offense in the 49ers' first eight games of 2025. With lead back Christian McCaffrey having thus far stayed healthy while handling huge snap and touch counts each week, Brian Robinson has picked up the remaining scraps left over in the backfield. So long as McCaffrey and Robinson are able to avoid injury, Guerendo looks as though he'll be limited to a role on kickoff returns and kick-coverage units.
OCTOBER 29, 2025 • ROTOWIRE
Returns one kickoff Thursday Guerendo ran back one kickoff for 18 yards while receiving no carries or targets in Thursday's 26-23 overtime win over the Rams.
Impact Christian McCaffrey continued to operate as San Francisco's bell cow (88 percent) while Brian Robinson (14 percent) remained the clear No. 2, which leaves Guerendo parked in the garage when the team is on offense. The 2024 fourth-round selection is stuck on special teams for the foreseeable future, needing an injury to open up playing time ahead of him on the depth chart. Guerendo generates no fantasy value in his current role when the 49ers visit the Buccaneers in Week 6.
OCTOBER 3, 2025 • ROTOWIRE
Logs 14 snaps on special teams Guerendo logged 14 snaps on special teams and was not used on offense in Sunday's 26-21 loss to the Jaguars.
Impact Guerendo couldn't even make an appearance in the box score as a return man after WR Skyy Moore handled all punt and kick returns Sunday. The 25-year-old Guerendo has logged zero snaps on offense through four games this season, leaving no room for fantasy utility as we encroach the quarter point of the season. Managers should have no concerns leaving Guerendo in the free agent pool for Thursday's tilt against the Rams.
SEPTEMBER 29, 2025 • ROTOWIRE
Stuck on special teams Guerendo did not receive a carry while gaining 19 yards on a kickoff return in Sunday's 16-15 win over the Cardinals.
Impact Guerendo continued to be used exclusively on special teams, logging all 15 of his snaps there Sunday. Brian Robinson was the only running back to receive any carries outside of starter Christian McCaffrey. Guerendo carries no fantasy value heading into a Week 4 matchup against Jacksonville.
SEPTEMBER 22, 2025 • ROTOWIRE
49ers' 2024 breakout rookie has been completely iced out of rushing attack The 49ers' rushing attack has only featured two players, as 2024 breakout rookie Isaac Guerendo has been iced out of the backfield.
SEPTEMBER 15, 2025 • NINERNOISE.COM
No carries in Week 2 win Guerendo returned two kickoffs for 47 yards and was not used on offense in Sunday's 26-21 win over the Saints.
Impact Guerendo failed to see the field on offense Sunday, logging all 17 of his snaps on special teams. Veteran backup Brian Robinson continues to handle all of the touches starter Christian McCaffrey doesn't gobble up on game days. More of the same can be expected against the Cardinals in Week 3, leaving Guerendo off the fantasy radar until an injury opens up playing time for the sophomore.
SEPTEMBER 15, 2025 • ROTOWIRE
Limited to special teams Guerendo played 15 snaps on special teams and did not receive a carry in Sunday's 17-13 win over the Seahawks.
Impact The good news for Guerendo was that he was fully cleared from the shoulder injury that limited him in camp. That bad news for the sophomore tailback is that new addition Brian Robinson usurped him on the depth chart. Guerendo dropped to third in the pecking order and was limited to special teams, returning one kickoff for 16 yards. In his current role, Guerendo provides no fantasy utility heading into next Sunday's tilt against the Saints.
SEPTEMBER 8, 2025 • ROTOWIRE
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