Isaac Guerendo - NFL News, Rumors, & Updates

Lands on reserve/PUP list Guerendo (pectoral) was placed on the reserve/PUP list, Jeremy Fowler of ESPN reports.

Impact Guerendo spent all of training camp on the active/PUP list and is seemingly not ready to take the field, so he will remain on PUP and will miss at least the first four weeks of the season. As such, Kaelon Black and Jordan James will open as the top two options behind starter Christian McCaffrey (undisclosed).

AUGUST 30 • ROTOWIRE

The 49ers head into final preseason week with several players hurt but expected back soon

The San Francisco 49ers held their final practice before their exhibition finale with nearly two dozen injured players missing but remain hopeful that most will be able to return t...

AUGUST 25 • Associated Press

One low-key awesome trade to push Bengals closer to Super Bowl glory The Cincinnati Bengals' running back depth behind Chase Brown is dubious at best. San Francisco 49ers speedster Isaac Guerendo is a perfect...

AUGUST 25 • STRIPEHYPE.COM

49ers Managing Christian McCaffrey’s Camp Load After Dealing With Tightness

San Francisco 49ers star running back Christian McCaffrey was held out of practice with what the team described as general tightness.

AUGUST 10 • FOX SPORTS

49ers Managing Christian McCaffrey’s Camp Load After Dealing With Tightness

Receiver Mike Evans misses practice for the 49ers with a strained quadriceps

Wide receiver Mike Evans missed practice for the San Francisco 49ers because of a strained quadriceps in the latest injury to hit the team’s receiver room

AUGUST 3 • Associated Press

49ers GM John Lynch tight-lipped as camp opens with Aiyuk in limbo on reserve/left squad list

Disgruntled receiver Brandon Aiyuk remains in limbo as the San Francisco 49ers opened training camp with Aiyuk still under contract to the team and unable to sign with another fran...

JULY 25 • Associated Press

Placed on PUP list The 49ers placed Guerendo (pectoral) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.

Impact Guerendo is still recovering from a torn pectoral he suffered while lifting earlier in the offseason. While the 26-year-old will be unable to practice for now, he is expected to return at some point before the end of training camp.

JULY 25 • ROTOWIRE

49ers' Isaac Guerendo gets bad roster news despite previous high hopes | Sporting News There was a time when Guerendo seemed to have a different fate.

JULY 24 • SPORTINGNEWS.COM

This Trade Offer is Too Good to be True for the 49ers The San Francisco 49ers are unlikely to get any trade offers for running back Isaac Guerendo

JUNE 3 • SI.COM

Isaac Guerendo might have cost himself a roster spot at 49ers OTAs Issac Guerendo might have cost himself a roster spot at organized team activities before training camp has fully begun.

JUNE 2 • NINERNOISE.COM

49ers RB Isaac Guerendo's injury news might be secret blessing in disguise Isaac Guerendo was dealt some bad injury news this offseason, but it might actually benefit his shaky tenure with the 49ers in the long run.

MAY 29 • NINERNOISE.COM

Nick Bosa Expects to Be 'On Track' for 49ers Season Opener Following Knee Surgery

Nick Bosa is encouraged by the pace of his recovery from another major knee surgery and believes he's on track to return to the field during...

MAY 29 • FOX SPORTS

Nick Bosa Expects to Be 'On Track' for 49ers Season Opener Following Knee Surgery

Dealing with torn pectoral Guerendo is not participating in OTAs due to a torn pectoral, Cam Inman of The San Jose Mercury News reports.

Impact The running back suffered the injury while lifting "about a month ago," per David Lombardi of SFStandard.com. Guerendo is expected back near the end of training camp, though he did already undergo surgery, per Jeremy Fowler of ESPN.com. The 2024 fourth-round pick did not receive a single carry in 2025 despite appearing in 14 regular-season games.

MAY 29 • ROTOWIRE

49ers RB Isaac Guerendo's Roster Spot in Jeopardy After Latest Injury This isn't the start that running back Isaac Guerendo wanted for OTAs. Kyle Shanahan revealed today that the third-year running back tore hi...

MAY 28 • SI.COM

Isaac Guerendo is now on thin ice after 49ers draft Kaelon Black The 49ers made it clear they don't trust Isaac Guerendo on the depth chart after selecting Kaelon Black in Round 3 of the NFL Draft.

APRIL 25 • NINERNOISE.COM

Why RB Isaac Guerendo is on Borrowed Time With the 49ers One of the reasons the San Francisco 49ers didn't ease up on Christian McCaffrey's workload last season was that they didn't have a running...

APRIL 4 • SI.COM

Under-the-radar 49ers signing likely seals the fate of 2 backup RBs The 49ers have retained running back Patrick Taylor Jr. which is not good news for free agent Brian Robinson Jr. or Isaac Guerendo.

MARCH 15 • NINERNOISE.COM

49ers' 2024 breakout rusher is as good as gone after a brutal 2025 campaign After Isaac Guerendo had a strong 2024 campaign with the San Francisco 49ers, he was pushed out of the picture in 2025 which may seal his fa...

JANUARY 26 • NINERNOISE.COM

Falls out of favor in 2025 Guerendo was only utilized on special teams this season, finishing with 100 kick return yards across 14 active games.

Impact Guerendo entered his sophomore campaign with an opportunity to serve as Christian McCaffrey's primary backup, but he failed to seize the role in training camp and the team opted to trade for veteran RB Brian Robison (92-400-2) to fill that role instead. The 25-year-old Guerendo averaged 5.0 yards per carry in his rookie season, so it was a bit surprising to see San Francisco's coaching staff give him zero carries in 2025. The Louisville product was healthy for the majority of the schedule and appeared in 14 games as a member of the special teams unit. Guerendo still has two years left on his rookie contract, but it doesn't appear that the 49ers view the running back as part of the team's long-term vision on offense.

JANUARY 8 • ROTOWIRE

49ers' Trent Williams and Ricky Pearsall miss crucial game against Seahawks with injuries

San Francisco 49ers Pro Bowl left tackle Trent Williams and receiver Ricky Pearsall missed the Week 18 game against the Seattle Seahawks due to injuries

JANUARY 4 • Associated Press

Healthy scratch again in Week 17 Guerendo (coach's decision) is inactive for Sunday night's contest against Chicago.

Impact Guerendo will be a healthy scratch for the second straight week after having played in the team's previous 14 contests. Jordan James will get another nod as the 49ers' No. 3 running back behind Christian McCaffrey and Brian Robinson in Week 17.

DECEMBER 29, 2025 • ROTOWIRE

49ers' George Kittle misses key game against Bears with ankle injury

San Francisco star tight end George Kittle will miss the 49ers’ key game in playoff positioning on Sunday night against the Chicago Bears with an ankle injury

DECEMBER 29, 2025 • Associated Press

Breakout 49ers RB's days are numbered after rookie gets elevated It has been a tough season for 49ers second-year running back Isaac Guerendo.

DECEMBER 26, 2025 • NINERNOISE.COM

Colts activate Pro Bowl DT DeForest Buckner for a crucial Monday night game against the 49ers

Pro Bowl defensive tackle DeForest Buckner was activated off injured reserve and will play Monday night when the Indianapolis Colts face the San Francisco 49ers

DECEMBER 23, 2025 • Associated Press

Inactive for MNF Guerendo (coach's decision) is inactive for Monday night's game against the Colts.

Impact Guerendo has appeared in all 14 games this season leading up to Monday night, but rookie Jordan James is getting the nod over him against the Colts as the Niners' RB3 behind Christian McCaffrey and Brian Robinson. All of Guerendo's 173 snaps this season have come on special teams.

DECEMBER 22, 2025 • ROTOWIRE

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