Duke vs. North Carolina Prediction, Odds, Picks – Women's Basketball NCAA Tournament Sweet 16 2025

Updated Mar. 28, 2025 2:02 p.m. ET

Data Skrive

A Sweet 16 NCAA Tournament matchup between the No. 2 Duke Blue Devils (28-7) and No. 3 North Carolina Tar Heels (29-7) will determine one of the squads heading to the regional final when it tips off on Friday at Legacy Arena at BJCC, tipping off at 2:30 p.m. ET, airing on ESPN. Sportsbooks think Duke will survive and advance in this one, naming the as 5.5-point favorites. The point total for the matchup is set at 121.5.

Duke vs. North Carolina Game Info

Game day: Friday, March 28, 2025
Game time: 2:30 p.m. ET
TV channel: ESPN
Follow this game live on FOX Sports

Duke vs. North Carolina Odds

Blue Devils vs Tar Heels Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Blue Devils	-5.5	-115	-105	121.5	-110	-110	-258	+210

Duke vs. North Carolina Prediction

Computer Pick ATS: Duke (-5.5)
Computer Pick OU: Over (121.5)
Computer Prediction: Duke 68, North Carolina 61

Learn more about the Duke Blue Devils vs. the North Carolina Tar Heels game on FOX Sports!

Duke Betting Insights

The Blue Devils have covered the spread 22 times in 33 games.
Duke's ATS record as 5.5-point favorites or more is 15-7.
This year, 10 of the Blue Devils' 33 games have gone over the point total.
Duke has entered the game as moneyline favorites 22 times this season and won 19, or 86.4%, of those games.
The Blue Devils are 14-2 this season when entering a game favored by -258 or more on the moneyline.

North Carolina Betting Insights

The Tar Heels are 18-17-0 against the spread this year.
As a 5.5-point underdog or more, North Carolina has one win ATS (1-2) this season.
This year, 13 of the Tar Heels' 35 games have hit the over.
North Carolina has been chosen as moneyline underdogs in six games this year and has walked away with the win three times (50%) in those games.
The Tar Heels have played as an underdog of +210 or more just one time this year and came away with a loss in that game.

Duke's Top Performers

Duke Leaders | Last 10 Games
Name	PTS	REB	ASST	STL	BLK	3PM
Oluchi Okananwa	11.5	5.3	2.0	1.1	0.0	0.9
Toby Fournier	11.6	4.6	0.7	0.8	0.6	0.1
Jadyn Donovan	3.4	5.7	2.2	1.1	1.9	0.0
Ashlon Jackson	11.7	2.9	1.8	0.5	0.3	2.1
Reigan Richardson	10.1	3.0	2.3	1.0	0.2	1.2

North Carolina's Top Performers

North Carolina Leaders | Last 10 Games
Name	PTS	REB	ASST	STL	BLK	3PM
Maria Gakdeng	11.5	9.7	0.9	0.9	1.0	0.0
Indya Nivar	9.5	5.3	2.0	1.8	0.4	0.2
Lexi Donarski	13.1	1.9	1.0	1.0	0.1	2.7
Alyssa Ustby	6.0	4.9	1.1	0.8	0.6	0.2
Lanie Grant	8.7	2.0	1.0	0.4	0.1	1.4