The Biggest NFL Upsets in Week 1 - 2025

Looking for upsets? More than one team beat the odds in Week 1 of the 2025 NFL season. Find out more about those underdogs who were victorious below.

Read more about last week's NFL games on FOX Sports!

NFL Week 1's Biggest Upsets

Chargers 27, Chiefs 21

• Spread: Chiefs -3
• Total: Over (47.5)
• Moneyline: Chiefs -165, Chargers +140

Raiders 20, Patriots 13

• Spread: Patriots -2.5
• Total: Under (44)
• Moneyline: Patriots -150, Raiders +125

Bills 41, Ravens 40

• Spread: Ravens -1.5
• Total: Over (50.5)
• Moneyline: Ravens -125, Bills +105

Vikings 27, Bears 24

• Spread: Bears -1
• Total: Over (43.5)
• Moneyline: Bears -115, Vikings -105

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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