Texans vs. 49ers 2025 Prediction, Odds, Picks - Oct 26

Updated Oct. 26, 2025 12:43 p.m. ET

Data Skrive

The Houston Texans (2-4) are favored by 2.5 points versus the San Francisco 49ers (5-2) on October 26, 2025, starting at 1 p.m. ET, airing on FOX. The total for this one is set at 42.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Texans vs. 49ers Odds & Betting Lines

Texans vs 49ers Betting Information updated as of October 26, 2025, 12:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Texans	-2.5	-120	100	42.5	-109	-121

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Texans vs. 49ers Prediction & Pick

Pick ATS: Texans (-2.5)
Pick OU: Under (42.5)
Prediction: Texans 21 - 49ers 18

How to Watch Houston vs. San Francisco

Game date: Sunday, October 26, 2025
Time: 1 p.m. ET
Venue: NRG Stadium
Location: Houston, Texas
TV: Watch on FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Texans vs. 49ers Recent Matchups

Over their last two meetings, San Francisco has totaled two wins versus Houston.
In their last two head-to-head matchups, San Francisco has racked up 49 points versus Houston, while giving up only 23 points.

Houston Betting Info

Houston has two wins versus the spread in six games this season.
The Texans have covered the spread twice this season (2-1 ATS) when playing as at least 2.5-point favorites.
Houston games this year have hit the over on two of six set point totals (33.3%).
When playing as the moneyline favorite, the Texans have won 66.7% of the time (2-1).
Based on this game's moneyline, the Texans' implied win probability is 60.8%.

Texans Stats

Stat	Average (Total)	Rank
Pass yards	198.2 (1,189)	23
Rush yards	106.2 (637)	18
Points scored	21.2 (127)	27
Pass yards against	179.0 (1,074)	5
Rush yards against	95.2 (571)	10
Points allowed	14.7 (88)	1

Houston's Key Players

Offense

C.J. Stroud has 1,305 passing yards, nine touchdowns and four interceptions this year. He has completed 64.8% of his passes, averaging 217.5 yards per game and 6.8 per attempt.
He has also rushed for 147 yards (third on the Texans) without scoring a touchdown on the ground, while averaging 24.5 rushing yards per game.
Nico Collins' 339 receiving yards this season have come from 46 targets and 26 receptions. He's averaging 56.5 receiving yards and 4.3 catches per game, with three receiving touchdowns.
In six games, Woody Marks has amassed 152 yards on the ground, averaging 25.3 yards per game and scoring one touchdown.
Marks has nine receptions on 14 targets for 116 yards, with two receiving TDs.
In the ground game, Nick Chubb averages 4.2 yards per attempt (26th in the NFL) and 44.2 yards per game for 265 total rushing yards. He has recorded two rushing touchdowns this season.

Defense

On defense, Will Anderson Jr. has 4.0 sacks (first on the Texans) to go with 7.0 TFL and 22 tackles in 2025.
Jalen Pitre has 2.0 TFL, 31 tackles, and three interceptions.
Kamari Lassiter has collected 38 tackles, 3.0 TFL, and one interception this year. He leads the Texans in tackles.
So far this season, Azeez Al-Shaair has 38 tackles. His tackle total leads the Texans.

San Francisco Betting Info

San Francisco has covered the spread in a game four times this year (4-3-0).
This year, the 49ers have one against-the-spread win in two games as an underdog of 2.5 points or more.
San Francisco games have gone over the total four times this season.
The 49ers have split the two games they've played as underdogs this season.
The moneyline for this contest implies a 43.5% chance of a victory for the 49ers.

49ers Stats

Stat	Average (Total)	Rank
Pass yards	271.3 (1,899)	1
Rush yards	95.3 (667)	24
Points scored	20.7 (145)	21
Pass yards against	216.6 (1,516)	18
Rush yards against	100.9 (706)	12
Points allowed	19.7 (138)	7

San Francisco's Key Players

Offense

Christian McCaffrey has rushed for three touchdowns this year, and has racked up 465 total rushing yards (66.4 per game and 3.5 per attempt).
On top of his rushing statistics, McCaffrey has caught 53 passes (on 68 targets) for 516 yards (first on the 49ers and eighth in the NFL), with three receiving touchdowns. He's averaging 73.7 yards per game.
Mac Jones has 1,404 passing yards, six touchdowns and four interceptions. His completion percentage is 67.0% and he averages 280.8 yards per game and 7.2 per attempt.
Jake Tonges has put up 224 receiving yards and three touchdowns on 25 receptions, while being targeted 34 times on the season.
Kendrick Bourne has 385 receiving yards from 25 receptions after getting 35 targets.

Defense

Dee Winters' 2025 output includes 43 tackles and 4.0 TFL through seven games. He is third on the 49ers in tackles.
Bryce Huff has registered 4.0 sacks in addition to his 6.0 TFL and 19 tackles over seven games.
Marques Sigle has 45 tackles, 1.0 TFL, and two passes defended in the 2025 campaign.
Deommodore Lenoir has 26 tackles, 3.0 TFL, and two passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.