Ravens vs. Bills 2025 Prediction, Odds, Picks - Sep 7

The Baltimore Ravens (0-0) are favored by 1.5 points versus the Buffalo Bills (0-0) on September 7, 2025, starting at 8:20 p.m. ET, airing on NBC. The matchup has an over/under of 50.5 points.

Keep up with the 2025 NFL season on FOX Sports.

Super Bowl Contenders: Lions vs. Packers & Ravens vs. Bills Previewed | FOX NFL Sunday

Howie Long, Curt Menefee, Terry Bradshaw, Rob Gronkowski, and Michael Strahan broke down two highly anticipated Week 1 matchups featuring four Super Bowl contenders: Lions vs. Packers and Ravens vs. Bills.

Ravens vs. Bills Odds & Betting Lines

Ravens vs. Bills Prediction & Pick

• Pick ATS: Bills (+1.5)
  
• Pick OU: Over (50.5)
  
• Prediction: Bills 27 - Ravens 25

How to Watch Baltimore vs. Buffalo

• Game date: Sunday, September 7, 2025
• Time: 8:20 p.m. ET
• Venue: Highmark Stadium
• Location: Orchard Park, New York
• TV: NBC
• Live Boxscore: FOX Sports

Ravens vs. Bills Recent Matchups

• In their past five head-to-head matchups, Baltimore has taken down Buffalo three times.
• In their last five head-to-head matchups, Baltimore has racked up 151 points versus Buffalo, while allowing only 80 points.

Baltimore Betting Info

• Baltimore put together an 11-6-0 record against the spread last season.
• The Ravens had an ATS record of 11-5 as 1.5-point favorites or greater last year.
• Baltimore games hit the over 13 out of 17 times last season.
• The Ravens finished with a 12-4 record in games they were favored on the moneyline last season (winning 75% of those games).
• Baltimore went 11-4 last year (winning 73.3% of its games) when it played as a moneyline favorite of -125 or shorter.
• The Ravens have a 55.6% chance to win this contest based on the moneyline's implied probability.

Ravens Stats (2024)

Baltimore's Key Players

Offense

• Lamar Jackson passed for 4,172 yards last year (to rank sixth in the NFL), with 41 touchdowns (second in the NFL) and four interceptions. He completed 66.7% of his attempts while averaging 245.4 yards per game and 8.8 per attempt.
• He added 915 yards on the ground, while scoring four rushing touchdowns. He averaged 53.8 yards per game and 6.6 per attempt.
• Derrick Henry averaged 113 rushing yards per game through 17 games (1,921 total yards to rank second in the NFL), while scoring 16 rushing touchdowns.
• Henry added 19 receptions (1.1 per game) for 193 yards (11.4 per game) with two receiving touchdowns. He was targeted 22 times in the passing attack.
• Over the course of 17 games played last season, Zay Flowers had 74 catches (4.4 receptions per game on 6.8 targets per game) for 1,059 yards and four receiving touchdowns.
• Mark Andrews had 673 receiving yards and 11 touchdowns (fourth in the NFL) from 55 receptions on 69 targets.

Defense

• Roquan Smith put up 1.5 sacks to go with four TFL, 154 tackles, and one interception over 16 games in 2024.
• Kyle Hamilton had one interception on top of 107 tackles, four TFL, two sacks, and nine passes defended.
• In the 2024 campaign, Kyle Van Noy had 41 tackles, 14 TFL, and 12.5 sacks in 16 games.
• Marlon Humphrey totaled 0.5 sacks as well as five TFL, 67 tackles, and six interceptions.

Buffalo Betting Info

• Buffalo covered 10 times in 17 matchups with a spread last year.
• The Bills had two wins ATS (2-1) as a 1.5-point underdog or more last year.
• Buffalo and its opponent combined to go over the point total 11 out of 17 times last season.
• The Bills were underdogs four times last season and won twice.
• Buffalo entered three games last season as the underdog by +105 or more and were 2-1 in those contests.
• The moneyline for this contest implies a 48.8% chance of a victory for the Bills.

Bills Stats (2024)

Buffalo's Key Players

Offense

• Josh Allen averaged 7.7 passing yards per attempt (eighth in NFL) and 233.2 yards per game last season, completing 63.6% of his passes on the way to 3,731 total yards, 28 TDs (seventh in NFL) and six INTs in 16 games.
• He added 531 yards on the ground, and scored 12 rushing TDs. He averaged 33.2 yards per game and 5.2 per attempt.
• James Cook averaged 63.1 rushing yards in 16 games (1,009 total yards), and scored 16 rushing TDs.
• Cook added 32 catches (2 per game) for 258 yards (16.1 per game) and two receiving TDs. He was targeted 38 times.
• Khalil Shakir recorded 821 yards receiving and four TDs on 76 receptions while being targeted 100 times last season.
• Ray Davis had 442 rushing yards and three rushing TDs, averaging 26 yards per game and 3.9 per attempt (36th in the NFL).
• Davis also caught 17 pass for 189 yards and three TDs. He was targeted 19 times and averaged 11.1 yards per game.

Defense

• In 2024, Gregory Rousseau had eight sacks to go along with 16 TFL and 53 tackles over 16 games.
• Dorian Williams had five TFL and 114 tackles over 16 games.
• Terrel Bernard recorded one sack and five TFL, 104 tackles, and two interceptions during the 2024 season.
• Damar Hamlin had two TFL, 88 tackles, and two interceptions.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Buffalo Bills

Baltimore Ravens