NFL Week 1 Predictions, Betting Odds & TV Schedule

The Dallas Cowboys versus the New York Giants is one of many compelling options on the Week 1 NFL slate.

Here's what you need to know in terms of the betting odds for Week 1 in the NFL.

Week 1 Betting Lines & Game Info

Kansas City Chiefs vs. Detroit Lions

Odds & Prediction

• Spread: Chiefs (-4)
• Moneyline: Chiefs -204, Lions +172
• Total: 53 points
• Prediction: Chiefs 30, Lions 22

How to Watch

• Game Date: Thursday, September 7
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: Kansas City, Missouri

Cleveland Browns vs. Cincinnati Bengals

Odds & Prediction

• Spread: Bengals (-1)
• Moneyline: Bengals -110, Browns -109
• Total: 46.5 points
• Prediction: Bengals 27, Browns 18

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Cleveland, Ohio

Baltimore Ravens vs. Houston Texans

Odds & Prediction

• Spread: Ravens (-9.5)
• Moneyline: Ravens -481, Texans +368
• Total: 43.5 points
• Prediction: Ravens 29, Texans 11

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Baltimore, Maryland

Indianapolis Colts vs. Jacksonville Jaguars

Odds & Prediction

• Spread: Jaguars (-3.5)
• Moneyline: Jaguars -194, Colts +165
• Total: 45.5 points
• Prediction: Jaguars 27, Colts 17

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Indianapolis, Indiana

Atlanta Falcons vs. Carolina Panthers

Odds & Prediction

• Spread: Falcons (-3.5)
• Moneyline: Falcons -187, Panthers +159
• Total: 40.5 points
• Prediction: Falcons 22, Panthers 21

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Atlanta, Georgia

Minnesota Vikings vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Vikings (-4)
• Moneyline: Vikings -207, Buccaneers +173
• Total: 45 points
• Prediction: Vikings 26, Buccaneers 19

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Minneapolis, Minnesota

New Orleans Saints vs. Tennessee Titans

Odds & Prediction

• Spread: Saints (-2.5)
• Moneyline: Saints -148, Titans +127
• Total: 41.5 points
• Prediction: Saints 23, Titans 16

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: New Orleans, Louisiana

Washington Commanders vs. Arizona Cardinals

Odds & Prediction

• Spread: Commanders (-7)
• Moneyline: Commanders -322, Cardinals +260
• Total: 37.5 points
• Prediction: Commanders 28, Cardinals 15

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Landover, Maryland

Pittsburgh Steelers vs. San Francisco 49ers

Odds & Prediction

• Spread: 49ers (-1.5)
• Moneyline: 49ers -121, Steelers +102
• Total: 41.5 points
• Prediction: 49ers 23, Steelers 18

How to Watch

• Game Date: Sunday, September 10
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Pittsburgh, Pennsylvania

Seattle Seahawks vs. Los Angeles Rams

Odds & Prediction

• Spread: Seahawks (-4.5)
• Moneyline: Seahawks -217, Rams +180
• Total: 45 points
• Prediction: Seahawks 26, Rams 19

How to Watch

• Game Date: Sunday, September 10
• Game Time: 4:25 PM ET
• TV Channel: Watch Online: FOX
• Location: Seattle, Washington

Chicago Bears vs. Green Bay Packers

Odds & Prediction

• Spread: Bears (-1.5)
• Moneyline: Bears -120, Packers +102
• Total: 41 points
• Prediction: Packers 26, Bears 19

How to Watch

• Game Date: Sunday, September 10
• Game Time: 4:25 PM ET
• TV Channel: Watch Online: FOX
• Location: Chicago, Illinois

Los Angeles Chargers vs. Miami Dolphins

Odds & Prediction

• Spread: Chargers (-3)
• Moneyline: Chargers -163, Dolphins +139
• Total: 50.5 points
• Prediction: Dolphins 25, Chargers 24

How to Watch

• Game Date: Sunday, September 10
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Inglewood, California

New England Patriots vs. Philadelphia Eagles

Odds & Prediction

• Spread: Eagles (-3.5)
• Moneyline: Eagles -184, Patriots +157
• Total: 44 points
• Prediction: Eagles 25, Patriots 20

How to Watch

• Game Date: Sunday, September 10
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Foxborough, Massachusetts

Denver Broncos vs. Las Vegas Raiders

Odds & Prediction

• Spread: Broncos (-3)
• Moneyline: Broncos -162, Raiders +139
• Total: 43 points
• Prediction: Broncos 23, Raiders 20

How to Watch

• Game Date: Sunday, September 10
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Denver, Colorado

New York Giants vs. Dallas Cowboys

Odds & Prediction

• Spread: Cowboys (-3.5)
• Moneyline: Cowboys -173, Giants +147
• Total: 44.5 points
• Prediction: Cowboys 26, Giants 19

How to Watch

• Game Date: Sunday, September 10
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: East Rutherford, New Jersey

New York Jets vs. Buffalo Bills

Odds & Prediction

• Spread: Bills (-2.5)
• Moneyline: Bills -137, Jets +116
• Total: 44.5 points
• Prediction: Bills 25, Jets 16

How to Watch

• Game Date: Monday, September 11
• Game Time: 8:15 PM ET
• TV Channel: ABC/ESPN
• Location: East Rutherford, New Jersey