How to Watch Cardinals vs. 49ers: Time, TV Channel and Live Stream – 2025 Week 11

Christian McCaffrey and the San Francisco 49ers (6-4) will visit Trey McBride and the Arizona Cardinals (3-6) on Sunday at 4:05 p.m. ET, in a matchup between a pair of the brightest stars in the NFL.

The 49ers are compiling 356.2 yards per game on offense (11th in NFL), and they rank 21st on defense with 339.4 yards allowed per game. The Cardinals rank 21st with 316.3 total yards per contest on offense, and they rank 21st with 339.4 total yards given up per game on defense.

We dive into all of the info you need before this matchup begins below, including how to watch on TV.

Check out the full NFL schedule on FOX Sports! Or visit FOX Sports' NFL hub for everything you need to make the most of this season’s action.

How to Watch Cardinals vs. 49ers

• When: Sunday, November 16, 2025 at 4:05 p.m. ET
• Where: State Farm Stadium in Glendale, Arizona
• TV: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Learn more about the San Francisco 49ers vs. the Arizona Cardinals on FOX Sports!

49ers vs. Cardinals: Head-to-Head

• In the past five meetings, San Francisco has a 3-2 record against Arizona.
• The Cardinals' record ATS is 3-2 the last five times they have played the 49ers, with those games outpacing the point total on three occasions.
• San Francisco has outpaced Arizona 143 points to 131 in the past five games.

49ers' 2025 Schedule

49ers Stats & Insights

• San Francisco ranks 22nd in pass defense this season (228.8 passing yards allowed per game), but has been shining on offense, ranking best in the NFL with 261.4 passing yards per game.
• The 49ers are putting up 94.8 rushing yards per game on offense (27th in the NFL), and they rank 16th on defense with 110.6 rushing yards allowed per game.
• San Francisco has the third-worst turnover margin in the league at -8, forcing seven turnovers (27th in NFL) while turning it over 15 times (27th in NFL).

49ers Key Players

• In 10 games for the 49ers, McCaffrey has piled up 626 rushing yards and four touchdowns while averaging 3.5 yards per carry.
• Mac Jones has suited up for eight games in 2025, and he's racked up 2,151 passing yards, 13 touchdowns, six interceptions and a 69.6% completion percentage.
• Jauan Jennings has been an integral part of the 49ers' aerial attack in 2025, posting 28 receptions for 324 yards and three touchdowns.

Cardinals' 2025 Schedule

Cardinals Stats & Insights

• Arizona ranks 21st in the NFL with 202.9 passing yards per game on offense, and it ranks 21st with 225.3 passing yards given up per contest on the defensive side of the ball.
• In terms of rushing, the Cardinals rank 17th in the NFL on offense (113.4 rushing yards per game) and 18th defensively (114.1 rushing yards allowed per contest).
• After forcing 13 turnovers (seventh in NFL) and turning the ball over 10 times (12th in NFL) this season, Arizona owns the 11th-ranked turnover margin of +3.

Cardinals Key Players

• McBride has 61 catches for 603 yards (67 per game) and six touchdowns in nine games.
• In six games, Jacoby Brissett has passed for 1,118 yards (186.3 per game), with eight touchdowns and one interception, and a completion percentage of 60.9%.
• Marvin Harrison Jr. has 34 catches for 525 yards (58.3 per game) and four touchdowns in nine games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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