Eagles vs. Buccaneers 2025 Prediction, Odds, Picks - Sep 28

The Philadelphia Eagles (3-0) are 3.5-point favorites over the Tampa Bay Buccaneers (3-0), in a matchup of two squads on winning streaks. The Eagles are winners of three in a row, while the Buccaneers have taken three in a row. An over/under of 44.5 points has been set for the matchup.

Keep up with the 2025 NFL season on FOX Sports.

Which teams are meeting or exceeding expectations? 🤔 | FOX NFL Kickoff

The FOX NFL Kickoff crew discussed which teams have met or exceeded expectations so far.

Eagles vs. Buccaneers Odds & Betting Lines

Eagles vs. Buccaneers Prediction & Pick

• Pick ATS: Buccaneers (+3.5)
  
• Pick OU: Over (44.5)
  
• Prediction: Eagles 25 - Buccaneers 24

How to Watch Philadelphia vs. Tampa Bay

• Game date: Sunday, September 28, 2025
• Time: 1 p.m. ET
• Venue: Raymond James Stadium
• Location: Tampa, Florida
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Eagles vs. Buccaneers Recent Matchups

• Tampa Bay holds a 4-1 record against Philadelphia in their last five matchups.
• In their last five head-to-head matchups, Tampa Bay has tallied 135 points versus Philadelphia, while surrendering only 87 points.

Philadelphia Betting Info

• Philadelphia has covered the spread on two occasions in 2025.
• The Eagles have covered the spread once when favored by 3.5 points or more this season (in two opportunities).
• Philadelphia's games this year have eclipsed the over/under one time in three opportunities (33.3%).
• The Eagles have yet to lose a game they were the moneyline favorite, going 3-0 in those matchups this season.
• The Eagles have an implied win probability, based on the moneyline, of 64.9%.

Eagles Stats

Philadelphia's Key Players

Offense

• Jalen Hurts has 479 passing yards in three games this year, averaging 159.7 per game with a 71.4% completion percentage and three touchdowns against zero interceptions.
• He has tacked on 117 rushing yards (39 per game) and four touchdowns on the ground.
• Saquon Barkley's rushing statline this season includes 194 yards and two TDs. He is averaging 64.7 yards per game and 3.3 per attempt (36th in the NFL).
• Barkley has 10 receptions on 12 targets for 39 yards. He has not scored a touchdown in the passing game.
• A.J. Brown has one touchdown catch this season, and has 12 receptions for 144 yards on 19 targets, while averaging four catches and 48 yards per game.
• DeVonta Smith has 15 receptions for 129 yards and one touchdown. He's been targeted 18 times in the passing game, and averages five receptions and 43 yards in three games played.

Defense

• On the defensive side, Zack Baun has one interception (eighth in the NFL) to go with 22 tackles, one TFL, and three passes defended in 2025.
• Jordan Davis has 16 tackles, two TFL, and one sack this season.
• This season, Cooper DeJean has recorded one TFL and 21 tackles.
• Jihaad Campbell has 18 tackles this year.

Tampa Bay Betting Info

• Tampa Bay has gone 2-1-0 against the spread this season.
• Games involving Tampa Bay have hit the over once this year.
• The Buccaneers won the only game they've played as the underdog this season.
• The bookmakers' moneyline implies a 39.4% chance of a victory for the Buccaneers.

Buccaneers Stats

Tampa Bay's Key Players

Offense

• In three games played this year, Baker Mayfield has amassed 615 passing yards, with six touchdowns (fifth in the NFL) against zero interceptions and completing 61.6% of his passes.
• On the ground, Mayfield has added 116 rushing yards (second on the Buccaneers).
• Emeka Egbuka has put together a 2025 campaign that includes 14 catches for 181 yards and three receiving touchdowns (fourth in the NFL) through three games played. He has been on the receiving end of 21 targets and is averaging 4.7 receptions per game.
• Bucky Irving has yet to score a rushing touchdown this season, but has totaled 174 rushing yards (58 per game and 3.1 per carry).
• Irving has helped in the passing attack, putting up 91 receiving yards (30.3 per game) on 14 catches (4.7 per game), while being targeted 14 times. He has one receiving touchdown.
• Mike Evans has been targeted 27 times, resulting in 14 catches for 140 yards .

Defense

• Tykee Smith has amassed one sack (second on the Buccaneers) to go with two TFL and 24 tackles over three games in 2025.
• Lavonte David has 22 tackles, two TFL, 1.5 sacks, and one pass defended.
• Over the 2025 campaign, Zyon McCollum has 24 tackles and one TFL in three games.
• SirVocea Dennis has put up three TFL and 17 tackles through three games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Tampa Bay Buccaneers

Philadelphia Eagles