Bills vs. Panthers 2025 Prediction, Odds, Picks - Oct 26

The Carolina Panthers (4-3) will be aiming to continue a three-game winning run against the Buffalo Bills (4-2). Despite that, the Bills are solid favorites, expected to win by at least a touchdown (currently -7.5). An over/under of 47.5 points has been set for the matchup.

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Bills vs. Panthers Odds & Betting Lines

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Bills vs. Panthers Prediction & Pick

• Pick ATS: Panthers (+7.5)
  
• Pick OU: Under (47.5)
  
• Prediction: Panthers 24 - Bills 22

How to Watch Buffalo vs. Carolina

• Game date: Sunday, October 26, 2025
• Time: 1 p.m. ET
• Venue: Bank of America Stadium
• Location: Charlotte, North Carolina
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Bills vs. Panthers Recent Matchups

• Buffalo and Carolina have been evenly matched over their last two meetings, sharing the same 1-1 record.
• Carolina has been outpaced by 11 points in its last two tilts versus Buffalo.

Buffalo Betting Info

• Buffalo has covered the spread two times in 2025.
• The Bills have not covered the spread this season (0-3 ATS) when playing as at least 7.5-point favorites.
• Buffalo contests this year have gone over the point total 50% of the time (three times in six games with a set point total).
• When playing as moneyline favorites, the Bills have won 60% of the time (3-2).
• The Bills have an implied win probability, based on the moneyline, of 79.8%.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has 1,397 passing yards, 11 touchdowns (10th in the NFL) and four interceptions this year. He has completed 68.5% of his passes, averaging 232.8 yards per game and 7.8 per attempt.
• He has tacked on 254 rushing yards (42.3 per game) and three touchdowns on the ground.
• James Cook averages 5 yards per carry (11th in the NFL) and 89.5 yards per game, and has 537 total rushing yards (fourth in the NFL). He has scored five rushing TDs this season.
• He has caught 12 passes (on 14 targets) for 89 receiving yards with zero touchdowns. He's averaging 14.8 receiving yards and two catches per game.
• Dalton Kincaid has three touchdown catches this season, and has 20 catches for 287 yards on 24 targets, while averaging four catches and 57.4 yards per game.
• Khalil Shakir has racked up 268 receiving yards and two touchdowns with 25 catches on 34 targets. He is averaging 4.2 receptions and 44.7 yards per game.

Defense

• Over on defense, Terrel Bernard has 30 tackles, three TFL, and one interception in 2025.
• Cole Bishop has two sacks (first on the Bills) in addition to his two TFL, 27 tackles, and one interception.
• Joey Bosa has put up 14 tackles, two TFL, and two sacks this year.
• So far this season, Shaq Thompson has 23 tackles, three TFL, and one sack.

Carolina Betting Info

• Carolina has put together a 5-2-0 record against the spread this year.
• This year, four Carolina games have gone over the point total.
• This season, the Panthers have been the underdog seven times and won four of those games.
• The bookmakers' moneyline implies a 24.4% chance of a victory for the Panthers.

Panthers Stats

Carolina's Key Players

Offense

• Bryce Young has passed for 1,288 yards this year, with 11 touchdowns (10th in the NFL) and five interceptions. He is completing 61.6% of his attempts while averaging 184 yards per game and 5.8 per attempt.
• On the ground, Young has added one rushing touchdown and 69 rushing yards (fourth on the Panthers).
• Rico Dowdle has 551 rushing yards (leading the Panthers and third in the NFL) and two rushing touchdowns, while averaging 78.7 yards per game and 5.6 per attempt (first in the NFL).
• Dowdle has also collected 121 receiving yards (17.3 per game) on 13 catches (1.9 per game). He's been targeted 17 times and has caught one touchdown pass.
• Through seven games played this season, Tetairoa McMillan has 30 catches (4.3 receptions per game on 7.6 targets per game) for 413 yards and two receiving touchdowns.
• Chuba Hubbard is scoreless on the ground, but has rushed for 248 total yards (3.7 per attempt and 49.6 per game).
• Hubbard has also caught 15 passes for 118 yards (fifth on the Panthers), with two receiving touchdowns. He's been targeted 20 times and averages 23.6 yards per game.

Defense

• So far in 2025, Tre'von Moehrig has recorded 46 tackles, six TFL, and one sack through seven games.
• Derrick Brown has registered three sacks in addition to his two TFL and 26 tackles through seven games.
• Christian Rozeboom has 50 tackles and one TFL during the 2025 campaign.
• Mike Jackson Sr. has registered two TFL, 28 tackles, and one interception through seven games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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