2025 NFL Week 2 Predictions, Betting Odds & TV Schedule

In one of the many exciting matchups on the NFL slate in Week 2, the Philadelphia Eagles and the Kansas City Chiefs take the field at GEHA Field at Arrowhead Stadium.

To get an edge ahead of Week 2 in the NFL, read our betting preview below.

Check out the full NFL schedule on FOX Sports!

Week 2 Betting Lines & Game Info

Green Bay Packers vs. Washington Commanders

Odds & Prediction

• Spread: Packers (-3)
• Moneyline: Packers -178, Commanders +149
• Total: 48.5 points
• Prediction: Packers 28, Commanders 22

How to Watch

• Game Date: Thursday, Sept. 11
• Game Time: 8:15 p.m. ET
• TV Channel: Amazon Prime Video
• Box Score
• Location: Green Bay, Wisconsin

Cincinnati Bengals vs. Jacksonville Jaguars

Odds & Prediction

• Spread: Bengals (-3.5)
• Moneyline: Bengals -187, Jaguars +156
• Total: 49.5 points
• Prediction: Bengals 30, Jaguars 18

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Cincinnati, Ohio

Dallas Cowboys vs. New York Giants

Odds & Prediction

• Spread: Cowboys (-5.5)
• Moneyline: Cowboys -243, Giants +198
• Total: 44.5 points
• Prediction: Cowboys 26, Giants 18

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Arlington, Texas

Miami Dolphins vs. New England Patriots

Odds & Prediction

• Spread: Dolphins (-2.5)
• Moneyline: Dolphins -130, Patriots +110
• Total: 43.5 points
• Prediction: Dolphins 25, Patriots 16

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Miami Gardens, Florida

Baltimore Ravens vs. Cleveland Browns

Odds & Prediction

• Spread: Ravens (-12.5)
• Moneyline: Ravens -952, Browns +623
• Total: 46.5 points
• Prediction: Ravens 36, Browns 10

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Baltimore, Maryland

Detroit Lions vs. Chicago Bears

Odds & Prediction

• Spread: Lions (-6.5)
• Moneyline: Lions -289, Bears +233
• Total: 46 points
• Prediction: Lions 35, Bears 12

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Detroit, Michigan

New Orleans Saints vs. San Francisco 49ers

Odds & Prediction

• Spread: 49ers (-3)
• Moneyline: 49ers -160, Saints +135
• Total: 40.5 points
• Prediction: 49ers 24, Saints 23

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: New Orleans, Louisiana

Tennessee Titans vs. Los Angeles Rams

Odds & Prediction

• Spread: Rams (-5.5)
• Moneyline: Rams -251, Titans +203
• Total: 41.5 points
• Prediction: Rams 28, Titans 16

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Nashville, Tennessee

New York Jets vs. Buffalo Bills

Odds & Prediction

• Spread: Bills (-6.5)
• Moneyline: Bills -287, Jets +232
• Total: 47.5 points
• Prediction: Bills 31, Jets 17

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: East Rutherford, New Jersey

Pittsburgh Steelers vs. Seattle Seahawks

Odds & Prediction

• Spread: Steelers (-3.5)
• Moneyline: Steelers -198, Seahawks +165
• Total: 40.5 points
• Prediction: Steelers 22, Seahawks 21

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Pittsburgh, Pennsylvania

Indianapolis Colts vs. Denver Broncos

Odds & Prediction

• Spread: Broncos (-1.5)
• Moneyline: Broncos -124, Colts +105
• Total: 43.5 points
• Prediction: Broncos 27, Colts 18

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 4:05 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Indianapolis, Indiana

Arizona Cardinals vs. Carolina Panthers

Odds & Prediction

• Spread: Cardinals (-7)
• Moneyline: Cardinals -331, Panthers +264
• Total: 45 points
• Prediction: Cardinals 34, Panthers 15

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 4:05 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Glendale, Arizona

Kansas City Chiefs vs. Philadelphia Eagles

Odds & Prediction

• Spread: Eagles (-1.5)
• Moneyline: Eagles -121, Chiefs +102
• Total: 47 points
• Prediction: Eagles 22, Chiefs 21

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 4:25 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Kansas City, Missouri

Minnesota Vikings vs. Atlanta Falcons

Odds & Prediction

• Spread: Vikings (-3.5)
• Moneyline: Vikings -173, Falcons +145
• Total: 44.5 points
• Prediction: Vikings 29, Falcons 17

How to Watch

• Game Date: Sunday, Sept. 14
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Box Score
• Location: Minneapolis, Minnesota

Houston Texans vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Texans (-2.5)
• Moneyline: Texans -145, Buccaneers +122
• Total: 42.5 points
• Prediction: Buccaneers 26, Texans 22

How to Watch

• Game Date: Monday, Sept. 15
• Game Time: 7 p.m. ET
• TV Channel: ABC/ESPN
• Box Score
• Location: Houston, Texas

Las Vegas Raiders vs. Los Angeles Chargers

Odds & Prediction

• Spread: Chargers (-3.5)
• Moneyline: Chargers -193, Raiders +161
• Total: 46.5 points
• Prediction: Chargers 26, Raiders 17

How to Watch

• Game Date: Monday, Sept. 15
• Game Time:10 p.m. ET
• TV Channel: ESPN
• Box Score
• Location: Paradise, Nevada

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

National Football League