2025 NFL Week 1 Predictions, Betting Odds & TV Schedule

The Week 1 NFL schedule has plenty of quality competition in store. Among those games is the Detroit Lions taking on the Green Bay Packers.

With Week 1 in the NFL upon us, stay on top of the latest betting trends with our preview below.

Check out the full NFL schedule on FOX Sports!

Week 1 Betting Lines & Game Info

Philadelphia Eagles vs. Dallas Cowboys

Odds & Prediction

• Spread: Eagles (-8)
• Moneyline: Eagles -437, Cowboys +341
• Total: 47.5 points
• Prediction: Eagles 34, Cowboys 12

How to Watch

• Game Date: Thursday, Sept. 4
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Box Score
• Location: Philadelphia, Pennsylvania

Los Angeles Chargers vs. Kansas City Chiefs

Odds & Prediction

• Spread: Chiefs (-3)
• Moneyline: Chiefs -172, Chargers +144
• Total: 47.5 points
• Prediction: Chiefs 21, Chargers 20

How to Watch

• Game Date: Friday, Sept. 5
• Game Time: 8 p.m. ET
• TV Channel: YouTube
• Box Score
• Location: São Paulo, Brazil

New York Jets vs. Pittsburgh Steelers

Odds & Prediction

• Spread: Steelers (-3)
• Moneyline: Steelers -163, Jets +138
• Total: 38 points
• Prediction: Steelers 24, Jets 19

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: East Rutherford, New Jersey

Cleveland Browns vs. Cincinnati Bengals

Odds & Prediction

• Spread: Bengals (-4.5)
• Moneyline: Bengals -230, Browns +190
• Total: 47.5 points
• Prediction: Bengals 28, Browns 19

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Cleveland, Ohio

Indianapolis Colts vs. Miami Dolphins

Odds & Prediction

• Spread: Colts (-1)
• Moneyline: Colts -117, Dolphins -102
• Total: 46.5 points
• Prediction: Colts 23, Dolphins 21

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Indianapolis, Indiana

New England Patriots vs. Las Vegas Raiders

Odds & Prediction

• Spread: Patriots (-2.5)
• Moneyline: Patriots -149, Raiders +125
• Total: 44.5 points
• Prediction: Patriots 22, Raiders 21

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Foxborough, Massachusetts

Atlanta Falcons vs. Tampa Bay Buccaneers

Odds & Prediction

• Spread: Buccaneers (-1.5)
• Moneyline: Buccaneers -111, Falcons -108
• Total: 47.5 points
• Prediction: Buccaneers 28, Falcons 22

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Atlanta, Georgia

Jacksonville Jaguars vs. Carolina Panthers

Odds & Prediction

• Spread: Jaguars (-4.5)
• Moneyline: Jaguars -218, Panthers +180
• Total: 46 points
• Prediction: Jaguars 28, Panthers 20

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Jacksonville, Florida

New Orleans Saints vs. Arizona Cardinals

Odds & Prediction

• Spread: Cardinals (-6)
• Moneyline: Cardinals -277, Saints +224
• Total: 44.5 points
• Prediction: Cardinals 26, Saints 19

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: CBS
• Box Score
• Location: New Orleans, Louisiana

Washington Commanders vs. New York Giants

Odds & Prediction

• Spread: Commanders (-6.5)
• Moneyline: Commanders -282, Giants +230
• Total: 45.5 points
• Prediction: Commanders 33, Giants 14

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 1 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Landover, Maryland

Seattle Seahawks vs. San Francisco 49ers

Odds & Prediction

• Spread: 49ers (-1.5)
• Moneyline: 49ers -130, Seahawks +110
• Total: 43.5 points
• Prediction: Seahawks 27, 49ers 19

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 4:05 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Seattle, Washington

Denver Broncos vs. Tennessee Titans

Odds & Prediction

• Spread: Broncos (-8.5)
• Moneyline: Broncos -481, Titans +366
• Total: 42.5 points
• Prediction: Broncos 33, Titans 11

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 4:05 p.m. ET
• TV Channel: FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
• Location: Denver, Colorado

Green Bay Packers vs. Detroit Lions

Odds & Prediction

• Spread: Packers (-1.5)
• Moneyline: Packers -116, Lions -103
• Total: 47.5 points
• Prediction: Lions 27, Packers 24

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Green Bay, Wisconsin

Los Angeles Rams vs. Houston Texans

Odds & Prediction

• Spread: Rams (-3)
• Moneyline: Rams -166, Texans +141
• Total: 43 points
• Prediction: Rams 25, Texans 19

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 4:25 p.m. ET
• TV Channel: CBS
• Box Score
• Location: Inglewood, California

Buffalo Bills vs. Baltimore Ravens

Odds & Prediction

• Spread: Ravens (-1.5)
• Moneyline: Ravens -123, Bills +103
• Total: 50.5 points
• Prediction: Bills 27, Ravens 25

How to Watch

• Game Date: Sunday, Sept. 7
• Game Time: 8:20 p.m. ET
• TV Channel: NBC
• Box Score
• Location: Orchard Park, New York

Chicago Bears vs. Minnesota Vikings

Odds & Prediction

• Spread: Vikings (-2.5)
• Moneyline: Vikings -109, Bears -110
• Total: 43.5 points
• Prediction: Vikings 26, Bears 16

How to Watch

• Game Date: Monday, Sept. 8
• Game Time: 8:15 p.m. ET
• TV Channel: ABC/ESPN
• Box Score
• Location: Chicago, Illinois

Learn more about today's games on FOX Sports.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Matt Hasselbeck on Josh Allen-Lamar Jackson, Justin Fields, Lions' offensive woes | FULL INTERVIEW | The Herd

Matt Hasselbeck joins Colin Cowherd to break down Josh Allen's comeback win vs. Baltimore Ravens and Lamar Jackson's performance, along with Justin Fields showing out despite losing to the Pittsburgh Steelers. He then discusses whether the Detroit Lions will gel in with a new offensive system after a lackluster performance against the Green Bay Packers. Hasselbeck also breaks down Micah Parsons' impact on the Packers and Brock Purdy's final drive against the Seattle Seahawks. He dives into the difference between the Indianapolis Colts and Miami Dolphins' cultures, along with the Las Vegas Raiders' win over the New England Patriots.