Yankees vs. Red Sox Prediction, Odds, Picks - August 21

Luis Gil is set to start for the New York Yankees on Thursday against Roman Anthony and the Boston Red Sox. First pitch is at 7:15 p.m. ET at Yankee Stadium. Oddsmakers list the Yankees as -147 favorites on the moneyline, while giving the underdog Red Sox +123 moneyline odds. New York is the run-line favorite (-1.5). The matchup's over/under is listed at 8.5 runs.

Take a look at everything you need to know from a betting perspective on the Yankees-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Derek Jeter & Alex Rodriguez: Are Yankees built to win a World Series this year? | MLB on FOX

Derek Jeter, Alex Rodriguez and the "MLB on FOX" Crew discussed whether they believed the New York Yankees are built to win the World Series this year after the MLB trade deadline.

Yankees vs. Red Sox Game Information & Odds

• When: Thursday, August 21, 2025 at 7:15 p.m. ET
• Where: Yankee Stadium in The Bronx, New York
• How to watch on TV: FOX

Yankees vs. Red Sox Prediction

• Score Prediction: Yankees 5, Red Sox 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Yankees 53%, Red Sox 47%

Yankees vs. Red Sox Betting Insights

• The Yankees have won 59, or 56.2%, of the 105 games they've played as favorites this season.
• New York has entered 70 games this season favored by -147 or more and is 43-27 in those contests.
• The moneyline for this contest implies a 59.5% chance of a victory for the Yankees.
• The Red Sox have won in 22, or 46.8%, of the 47 contests they have been named as odds-on underdogs this year.
• This season, Boston has come away with a win seven times in 19 chances when named as an underdog of at least +123 or worse on the moneyline.
• The moneyline set for this matchup implies the Red Sox have a 44.8% chance of coming away with a victory in the contest.

Yankees Recent Betting Performance

• The Yankees were favored on the moneyline in eight of their last 10 games, and they finished 6-2 in those matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Yankees and their opponents combined to hit the over six times.
• The Yankees are 7-3-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge's 40 homers and 92 RBI both lead the Yankees, on top of his team-high .330 average.
• Of all hitters in MLB, Judge is fourth in homers and fifth in RBI.
• Cody Bellinger has 20 doubles, five triples, 24 home runs and 37 walks while batting .272.
• Bellinger ranks 27th in home runs and 22nd in RBI on the season.
• Bellinger carries a three-game streak with at least one hit into this contest. In his last five games he is hitting .333 with three home runs, a walk and seven RBIs.
• Trent Grisham is batting .249 with nine doubles, a triple, 23 home runs and 58 walks.
• Anthony Volpe has 26 doubles, four triples, 18 home runs and 40 walks while hitting .213.

Yankees Team Props

Red Sox Recent Betting Performance

• The Red Sox have played as underdogs in four of their past 10 games and won one of those contests.
• In their last 10 games with a total, the Red Sox and their opponents are 6-4-0 when it comes to hitting the over.
• The Red Sox have three wins against the spread in their last 10 chances.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran paces the Red Sox with a team-leading batting average of .261.
• Among all hitters in MLB, Duran ranks 138th in homers and 39th in RBI.
• Trevor Story has driven in the most runs for the Red Sox with 79 runs batted in.
• Story is currently 53rd in home runs and 18th in RBI in the big leagues.
• Ceddanne Rafaela is batting .252 with 25 doubles, three triples, 14 home runs and 21 walks.
• Alex Bregman is hitting .298 with 23 doubles, 16 home runs and 36 walks.

Red Sox Team Props

Derek Jeter & Alex Rodriguez: Are Yankees built to win a World Series this year? | MLB on FOX

Derek Jeter, Alex Rodriguez and the "MLB on FOX" Crew discussed whether they believed the New York Yankees are built to win the World Series this year after the MLB trade deadline.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

New York Yankees

Boston Red Sox