Yankees vs. Orioles Prediction, Odds, Picks - September 19

Gunnar Henderson and the Baltimore Orioles hit the field on Friday at Oriole Park at Camden Yards against Will Warren, who gets the start for the New York Yankees. First pitch will be at 7:05 p.m. ET for the second game of a four-game series. The Yankees are the favorite in this one, at -116, while the underdog Orioles have -104 odds to win. New York is favored on the run line (-1.5 with +141 odds). The over/under for the contest is set at 9 runs.

Here's everything you need to know from a betting perspective on the Yankees-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Enjoy the best moments between the New York Yankees and Baltimore Orioles.

Yankees vs. Orioles Game Information & Odds

• When: Friday, September 19, 2025 at 7:05 p.m. ET
• Where: Oriole Park at Camden Yards in Baltimore, Maryland
• How to watch on TV: MASN and YES

Yankees vs. Orioles Prediction

• Score Prediction: Yankees 5, Orioles 4
• Total Prediction: Under 9 runs
• Win Probabilities: Yankees 53%, Orioles 47%

Yankees vs. Orioles Betting Insights

• The Yankees have entered the game as favorites 130 times this season and won 76, or 58.5%, of those games.
• New York has entered 127 games this season favored by -116 or more and is 74-53 in those contests.
• The Yankees have a 53.7% chance to win this game based on the implied probability of the moneyline.
• The Orioles have been underdogs in 86 games this season and have come away with the win 39 times (45.3%) in those contests.
• Baltimore has a mark of 36-44 in contests where bookmakers favor it by -104 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Orioles have a 51% chance of pulling out a win.

Yankees Recent Betting Performance

• The Yankees have a 6-3 record from the nine games they were favored on the moneyline over their last 10 matchups.
• Over their last 10 matchups, the Yankees and their opponents combined to go over the run total six times (all 10 of the games had set totals).
• The Yankees have a 5-5-0 record against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Not only does Aaron Judge lead the Yankees in hitting with his .328 average, he also is their premier power option with 48 home runs and 104 RBI.
• Judge's home runs place him fourth in MLB, and he is seventh in RBI.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 50 walks while batting .273.
• Bellinger is 22nd in home runs and 13th in RBI in the majors.
• Trent Grisham is hitting .239 with nine doubles, a triple, 33 home runs and 74 walks.
• Jazz Chisholm is batting .242 with 14 doubles, a triple, 29 home runs and 56 walks.

Yankees Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in six of their past 10 games and have gone 2-4 in those contests.
• The Orioles and their opponents have combined to hit the over three times in their last 10 games with a total.
• The Orioles are 4-6-0 ATS over their last 10 games.

Orioles Recent Stats

Orioles Player Insights

• The Orioles are led in runs batted in by Henderson with a mark of 64, he also leads the team in hitting, posting an average of .273.
• Henderson's home run total places him 117th in MLB, and he is 98th in RBI.
• Henderson has collected a hit in three games in a row. During his last five outings he is batting .350 with two walks and two RBIs.
• Jackson Holliday has launched a team-high 17 home runs.
• Among all major league batters, Holliday ranks 103rd in homers and 132nd in RBI.
• Jordan Westburg has nine doubles, a triple, 15 home runs and 17 walks while hitting .264.
• Colton Cowser is batting .199 with 12 doubles, 15 home runs and 22 walks.

Orioles Team Props

Yankees vs. Orioles Highlights | MLB on FOX

Enjoy the best moments between the New York Yankees and Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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