Yankees vs. Cardinals Prediction, Odds, Picks - August 16

Willson Contreras and the St. Louis Cardinals are ready for a matchup with Cody Bellinger and the New York Yankees on Saturday at 7:15 p.m. ET. The favored Yankees have -147 moneyline odds against the underdog Cardinals, who are listed at +123. New York is a 1.5-run favorite (at +115 odds). The total is 9 runs for the matchup.

Here's everything you need to know from a betting perspective on the Yankees-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Yankees vs. Cardinals Game Information & Odds

• When: Saturday, August 16, 2025 at 7:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FOX

Yankees vs. Cardinals Prediction

• Score Prediction: Yankees 5, Cardinals 4
• Total Prediction: Under 9 runs
• Win Probabilities: Yankees 50%, Cardinals 50%

Yankees vs. Cardinals Betting Insights

• The Yankees have been favorites in 102 games this season and won 56 (54.9%) of those contests.
• New York has a record of 42-27 in games when bookmakers favor them by at least -147 on the moneyline.
• The oddsmakers' moneyline implies a 59.5% chance of a victory for the Yankees.
• The Cardinals have been chosen as underdogs in 65 games this year and have walked away with the win 32 times (49.2%) in those games.
• This season, St. Louis has come away with a win 11 times in 26 chances when named as an underdog of at least +123 or worse on the moneyline.
• The Cardinals have an implied victory probability of 44.8% according to the moneyline set for this matchup.

Yankees Recent Betting Performance

• The Yankees were the moneyline favorite for eight of their last 10 games, and they went 4-4 in those matchups.
• Over their last 10 matchups -- all had a set run total -- the Yankees and their opponents combined to go over the total four times.
• The Yankees have gone 3-7-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge paces the Yankees in home runs (38), runs batted in (89) and has a team-best batting average of .330.
• Of all hitters in the majors, Judge ranks fourth in home runs and sixth in RBI.
• Bellinger is hitting .267 with 20 doubles, five triples, 22 home runs and 37 walks.
• Bellinger is 32nd in homers and 28th in RBI among all hitters in baseball.
• Anthony Volpe is hitting .217 with 25 doubles, four triples, 18 home runs and 40 walks.
• Trent Grisham is batting .242 with nine doubles, a triple, 21 home runs and 55 walks.

Yankees Team Props

Cardinals Recent Betting Performance

• The Cardinals have played as underdogs in seven of their past 10 games and won four of those contests.
• When it comes to hitting the over, the Cardinals and their opponents are 3-7-0 in their last 10 games with a total.
• The Cardinals have five wins against the spread in their last 10 chances.

Cardinals Recent Stats

Cardinals Player Insights

• Brendan Donovan leads the Cardinals with a .279 batting average.
• Donovan is 179th in home runs and 133rd in RBI among all batters in the majors.
• Alec Burleson's .279 batting average paces his team.
• Burleson ranks 92nd among all hitters in the big leagues in homers, and 82nd in RBI.
• Contreras has been a significant run producer for the Cardinals with 16 home runs and 65 runs batted in.
• Masyn Winn has 26 doubles, eight home runs and 31 walks while hitting .265.

Cardinals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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