Twins vs. Cardinals Prediction, Odds, Picks - March 29

Willi Castro and Alec Burleson will be among the star attractions when the Minnesota Twins face the St. Louis Cardinals on Saturday at 2:15 p.m. ET, at Busch Stadium. Oddsmakers list the Twins as -111 moneyline favorites, while giving the underdog Cardinals -108 moneyline odds to win. Minnesota is favored on the run line (-1.5 with +152 odds). The over/under is 7.5 runs for the matchup (with -111 odds on the over and -109 odds to go under).

Here's everything you need to know from a betting perspective on the Twins-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Nolan Arenado hits a walk-off single to seal Cardinals' victory over Padres

Nolan Arenado came up clutch with a walk-off single that sealed the St. Louis Cardinals' 4-3 victory over the San Diego Padres.

Twins vs. Cardinals Game Information & Odds

• When: Saturday, March 29, 2025 at 2:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to Watch on TV: Fox Sports 1, FDSMW, and MNNT

Twins vs. Cardinals Prediction

• Score Prediction: Cardinals 6, Twins 3
• Total Prediction: Over 7.5 runs
• Win Probabilities: Twins 69%, Cardinals 31%

Twins vs. Cardinals Betting Insights

• The Twins went 63-50 in games they were favored on the moneyline last season (winning 55.8% of those games).
• Minnesota had a record of 63-49 when playing as a moneyline favorite with odds of -111 or shorter last year (56.2%).
• The Twins have an implied moneyline win probability of 52.6% in this matchup.
• Last season, the Cardinals won 42 out of the 83 games, or 50.6%, in which they were the underdog.

Twins Player Insights

• Castro finished last season with a .247 batting average while adding 12 home runs and 60 RBI.
• Carlos Correa hit .310 with an OBP of .388 and a slugging percentage of .517.
• Ryan Jeffers slugged 21 home runs and collected 64 RBI last season while batting .226.
• Byron Buxton collected 99 hits, posted an OBP of .335 and a .524 SLG.

Twins Team Props

Cardinals Player Insights

• Brendan Donovan racked up 163 hits with a batting average of .278 last season.
• Burleson hit 21 home runs with 78 runs batted in last year.
• Masyn Winn hit .267 last season with 32 doubles, five triples, 15 home runs and 41 walks.
• Nolan Arenado hit .272 with 23 doubles, 16 home runs and 44 walks.

Cardinals Team Props

Nolan Arenado hits a walk-off single to seal Cardinals' victory over Padres

Nolan Arenado came up clutch with a walk-off single that sealed the St. Louis Cardinals' 4-3 victory over the San Diego Padres.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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