Royals vs. White Sox Prediction, Odds, Picks - May 6

Seth Lugo takes the mound for the Kansas City Royals on Tuesday at Kauffman Stadium against Miguel Vargas and the Chicago White Sox. First pitch is set for 7:40 p.m. ET in this second game of a four-game series. The Royals are -260 moneyline favorites in this matchup against the White Sox (+210). Kansas City is the favorite on the run line (-1.5 with -119 odds). An 8.5-run over/under is listed in this matchup.

Take a look at everything you need to know from a betting perspective on the Royals-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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White Sox vs. Royals Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Kansas City Royals.

Royals vs. White Sox Game Information & Odds

• When: Tuesday, May 6, 2025 at 7:40 p.m. ET
• Where: Kauffman Stadium in Kansas City, Missouri
• How to watch on TV: FDSKC and CHSN

Royals vs. White Sox Prediction

• Score Prediction: Royals 4, White Sox 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Royals 58%, White Sox 42%

Royals vs. White Sox Betting Insights

• The Royals have won 10, or 71.4%, of the 14 games they've played as favorites this season.
• Kansas City has played as favorites of -260 or more twice this season and won both games.
• The oddsmakers' moneyline implies a 72.2% chance of a victory for the Royals.
• The White Sox have come away with 10 wins in the 35 contests they have been listed as the underdogs in this season.
• This year, Chicago has won one of five games when listed as at least +210 or worse on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 32.3% chance of coming away with a victory in the contest.

Royals Recent Betting Performance

• The Royals have been named the moneyline favorite by bookmakers only once in the last 10 games, and won that matchup.
• Over their last 10 outings (all had set totals), the Royals combined with their opponents to hit the over on the run total three times.
• The Royals have put together an 8-2-0 record against the spread over their past 10 games.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. is hitting .314 with 14 doubles, four home runs and 15 walks.
• Among all hitters in MLB, Witt's home run total places him 91st, and his RBI tally puts him 53rd.
• Witt has collected a hit in two straight games. During his last five outings he is hitting .263 with two doubles, two home runs, three walks and six RBIs.
• Maikel Garcia is hitting .322 to pace his team.
• Garcia is 91st in home runs in the majors, and 88th in RBI.
• Garcia has three games in a row with at least one hit. During his last five outings he is hitting .556 with a double, two home runs, four walks and five RBIs.
• Vinnie Pasquantino has a team-high six home runs and 22 runs batted in.
• Jonathan India is batting .230 with six doubles, a home run and 19 walks.
• India takes a three-game streak with at least one hit into this one. In his last five games he is hitting .300 with a double, a home run, three walks and an RBI.

Royals Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and have gone 4-6 in those contests.
• The White Sox and their opponents have combined to hit the over seven times in their last 10 games with a total.
• The White Sox have a record of 6-4-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Luis Robert has managed a team-leading five home runs and has driven in 15 runs.
• Robert is 59th in homers and 88th in RBI among all batters in the majors.
• Vargas is hitting .223 with six doubles, two home runs and 15 walks.
• Vargas is 182nd in home runs and 148th in RBI among all MLB hitters this season.
• Andrew Benintendi has five home runs, best in the lineup.
• Brooks Baldwin is batting .240 with five doubles, three home runs and five walks.

White Sox Team Props

White Sox vs. Royals Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Kansas City Royals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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