Reds vs. White Sox Prediction, Odds, Picks - May 13

TJ Friedl and Miguel Vargas will look to continue their recent offensive production when the Cincinnati Reds and Chicago White Sox hit the field at Great American Ball Park on Tuesday, at 6:40 p.m. ET. Oddsmakers list the Reds as -212 moneyline favorites, while giving the underdog White Sox +176 moneyline odds to win. Cincinnati (-1.5) is the favorite on the run line. The over/under for the matchup has been set at 9 runs.

Take a look at everything you need to know from a betting perspective on the Reds-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Reds vs. White Sox Game Information & Odds

• When: Tuesday, May 13, 2025 at 6:40 p.m. ET
• Where: Great American Ball Park in Cincinnati, Ohio
• How to watch on TV: FDSOH and CHSN

Reds vs. White Sox Prediction

• Score Prediction: Reds 4, White Sox 3
• Total Prediction: Under 9 runs
• Win Probabilities: Reds 57%, White Sox 43%

Reds vs. White Sox Betting Insights

• The Reds have entered the game as favorites 19 times this season and won 10, or 52.6%, of those games.
• Cincinnati has not entered a game this season as bigger favorites on the moneyline than the -212 odds on them winning this game.
• The moneyline for this contest implies a 67.9% chance of a victory for the Reds.
• The White Sox have been victorious in 12, or 29.3%, of the 41 contests they have been chosen as underdogs in this season.
• This season, Chicago has been victorious four times in 20 chances when named as an underdog of at least +176 or longer on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the White Sox have a 36.2% chance of pulling out a win.

Reds Recent Betting Performance

• The Reds have a 1-2 record from the three games they were favored on the moneyline over their last 10 matchups.
• In their last 10 outings (all 10 of them had set totals), the Reds and their opponents combined to go over the run total three times.
• The Reds have a 4-6-0 record against the spread over their past 10 games.

Reds Recent Stats

Reds Player Insights

• Friedl has six doubles, a triple, three home runs and 20 walks while batting .276.
• In all of MLB, Friedl ranks 154th in home runs and 109th in RBI.
• Elly De La Cruz has hit six home runs with 29 RBI. Both are team-highs.
• De La Cruz ranks 61st in home runs and 14th in RBI among all hitters in baseball.
• Gavin Lux has a team-best batting average of .282.
• Jose Trevino is hitting .310 with 10 doubles, three home runs and five walks.
• Trevino is riding a two-game hitting streak into this one. In his last five games he is hitting .263 with four doubles and an RBI.

Reds Team Props

White Sox Recent Betting Performance

• In 10 games as underdogs over the last 10 matchups, the White Sox have a record of 4-6.
• In their last 10 games with a total, the White Sox and their opponents have combined to hit the over four times.
• The White Sox have six wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Luis Robert has put up a team-high five home runs.
• Robert's home run total places him 83rd in MLB, and he ranks 127th in RBI.
• Vargas is hitting .215 with eight doubles, two home runs and 17 walks.
• Vargas ranks 200th in homers and 179th in RBI among all hitters in the big leagues.
• Andrew Vaughn paces the White Sox in home runs (five) and runs batted in (17).
• Matthew Thaiss is batting .224 with four doubles, a home run and 18 walks.

White Sox Team Props

White Sox's Miguel Vargas & Andrew Benintendi collide on a pop fly to allow three runs to score for the Orioles

Chicago White Sox's Miguel Vargas & Andrew Benintendi collided on a pop fly to allow three runs to score for the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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