Red Sox vs. Blue Jays Prediction, Odds, Picks - September 24

George Springer and Alex Bregman will hit the field when the Toronto Blue Jays and Boston Red Sox meet on Wednesday at Rogers Centre. The Red Sox are -128 moneyline favorites in this matchup with the Blue Jays (+108). Boston (-1.5) is favored on the run line. The over/under is 7.5 runs for the game (with -102 odds to go over and -119 odds to go under).

Here is everything you need from a betting perspective on the Red Sox-Blue Jays game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Red Sox vs. Rays Highlights | MLB on FOX

Check out the best highlights between the Boston Red Sox and the Tampa Bay Rays.

Red Sox vs. Blue Jays Game Information & Odds

• When: Wednesday, September 24, 2025 at 7:07 p.m. ET
• Where: Rogers Centre in Toronto, Ontario
• How to watch on TV: SNET and NESN

Red Sox vs. Blue Jays Prediction

• Score Prediction: Blue Jays 6, Red Sox 5
• Total Prediction: Over 7.5 runs
• Win Probabilities: Red Sox 52%, Blue Jays 48%

Red Sox vs. Blue Jays Betting Insights

• This season, the Red Sox have been favored 97 times and won 56, or 57.7%, of those games.
• Boston has entered 62 games this season favored by -128 or more and is 35-27 in those contests.
• The moneyline for this contest implies a 56.1% chance of a victory for the Red Sox.
• The Blue Jays have won in 42, or 57.5%, of the 73 contests they have been named as odds-on underdogs this year.
• This season, Toronto has come away with a win 24 times in 41 chances when named as an underdog of at least +108 or worse on the moneyline.
• The moneyline set for this matchup implies the Blue Jays have a 48.1% chance of walking away with the win.

Red Sox Recent Betting Performance

• The Red Sox were the moneyline favorite for six of their last 10 games, and finished 3-3 in those matchups.
• Over their last 10 outings (all had set totals), the Red Sox combined with their opponents to hit the over on the total four times.
• The Red Sox have put together a 4-6-0 record against the spread over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran has been stellar at getting on base for the Red Sox this season, leading the team with a .334 OBP and 156 base hits.
• In all of MLB, Duran ranks 123rd in home runs and 42nd in RBI.
• Trevor Story has shown off his power as he leads his team with 25 home runs and 95 RBI, with a team-high .264 batting average.
• Story is 45th in home runs and 18th in RBI among all MLB hitters this season.
• Story enters this game looking for his fourth game in a row with a hit. During his last five outings he is batting .208 with two doubles, a home run, a walk and three RBIs.
• Bregman has 27 doubles, 18 home runs and 49 walks while batting .275.
• Ceddanne Rafaela is batting .244 with 31 doubles, three triples, 16 home runs and 26 walks.
• Rafaela takes a four-game streak with at least one hit into this one. During his last five outings he is batting .368 with two doubles, a walk and two RBIs.

Red Sox Team Props

Blue Jays Recent Betting Performance

• The Blue Jays have been underdogs once in the past 10 games and won that contest.
• In their last 10 games with a total, the Blue Jays and their opponents have combined to hit the over five times.
• The Blue Jays are 2-8-0 ATS over their last 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. is batting .297 with 34 doubles, 23 home runs and 81 walks, while getting on base at a rate of .388.
• Among all hitters in the big leagues, Guerrero's home run total is 56th and his RBI tally is 37th.
• Springer has put his power on display as he leads his team with 30 home runs.
• Among all major league hitters, Springer is 21st in home runs and 49th in RBI.
• Ernie Clement has 33 doubles, two triples, nine home runs and 26 walks while batting .277.
• Alejandro Kirk has 17 doubles, 12 home runs and 48 walks while hitting .283.

Blue Jays Team Props

Blue Jays vs. Royals Highlights | MLB on FOX

Check out the best highlights between the Toronto Blue Jays and Kansas City Royals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Toronto Blue Jays

Boston Red Sox