Padres vs. Reds Prediction, Odds, Picks - September 9

Fernando Tatis Jr. and the San Diego Padres will attempt to take down Austin Hays and the Cincinnati Reds when the teams meet on Tuesday at 9:40 p.m. ET. The favored Padres have -193 moneyline odds to win against the underdog Reds, who are listed at +160. San Diego is the favorite on the run line (-1.5). The over/under for the matchup is set at 7.5 runs.

Here is everything you need from a betting perspective on the Padres-Reds game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Reds Game Information & Odds

• When: Tuesday, September 9, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: MLB Network, SDPA, and FDSOH

Padres vs. Reds Prediction

• Score Prediction: Padres 5, Reds 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Padres 54%, Reds 46%

Padres vs. Reds Betting Insights

• The Padres have won 47, or 59.5%, of the 79 games they've played as favorites this season.
• San Diego has entered 14 games this season favored by -193 or more and is 9-5 in those contests.
• Oddsmakers have implied with the moneyline set for this matchup that the Padres have a 65.9% chance to win.
• The Reds have been underdogs in 78 games this season and have come away with the win 37 times (47.4%) in those contests.
• This season, Cincinnati has come away with a win one time in seven chances when named as an underdog of at least +160 or longer on the moneyline.
• The Reds have an implied victory probability of 38.5% according to the moneyline set for this matchup.

Padres Recent Betting Performance

• The Padres have a 4-5 record across the nine games they were favored on the moneyline in their last 10 matchups.
• In their last 10 outings, the Padres and their opponents combined to go over the total five times (all 10 games had set totals).
• The Padres are 3-7-0 against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Tatis is hitting .262 with 27 doubles, two triples, 20 home runs and 83 walks.
• Among all hitters in MLB, Tatis ranks 65th in home runs and 92nd in RBI.
• Tatis carries a five-game hitting streak into this matchup. In his last five games he is batting .261 with two home runs, a walk and five RBIs.
• Manny Machado's 23 home runs and 84 runs batted in both pace his team.
• Machado is 47th in homers and 25th in RBI among all MLB hitters this year.
• Luis Arraez has racked up a team-best batting average of .283.
• Ramon Laureano has shown his power as he leads his team with 23 home runs.

Padres Team Props

Reds Recent Betting Performance

• The Reds have played as underdogs in five of their past 10 games and won one of those contests.
• In their last 10 games with a total, the Reds and their opponents are 5-4-1 when it comes to hitting the over.
• The Reds have won four of their last 10 games against the spread.

Reds Recent Stats

Reds Player Insights

• Elly De La Cruz has posted a team-leading 19 home runs and has driven in 81 runs.
• Among all hitters in the majors, De La Cruz ranks 72nd in homers and 27th in RBI.
• TJ Friedl is batting .266 with 20 doubles, two triples, 12 home runs and 70 walks.
• Friedl ranks 158th overall in homers and 166th in RBI this year.
• Spencer Steer is batting .237 with 20 doubles, two triples, 17 home runs and 45 walks.
• Hays is batting .265 with 15 doubles, five triples, 15 home runs and 27 walks.

Reds Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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