Padres vs. Rays Prediction, Odds, Picks - April 27

Fernando Tatis Jr. and the San Diego Padres square off against Yandy (Fernandez) Diaz and the Tampa Bay Rays on Sunday at 4:10 p.m. ET, in the final of a three-game series at PETCO Park. The Padres are -146 moneyline favorites in this matchup against the Rays (+122). San Diego (-1.5) is the favorite on the run line. The over/under for the contest is listed at 7 runs.

Take a look at everything you need from a betting perspective on the Padres-Rays game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Rays Game Information & Odds

• When: Sunday, April 27, 2025 at 4:10 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and FDSSUN

Padres vs. Rays Prediction

• Score Prediction: Padres 4, Rays 3
• Total Prediction: Under 7 runs
• Win Probabilities: Padres 59%, Rays 41%

Padres vs. Rays Betting Insights

• The Padres have entered the game as favorites 15 times this season and won 11, or 73.3%, of those games.
• San Diego is 7-2 this season when entering a game favored by -146 or more on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Padres have a 59.3% chance to win.
• The Rays have been chosen as underdogs in 11 games this year and have walked away with the win five times (45.5%) in those games.
• This year, Tampa Bay has won three of six games when listed as at least +122 or worse on the moneyline.
• The moneyline set for this matchup implies the Rays have a 45% chance of walking away with the win.

Padres Recent Betting Performance

• The Padres went 1-3 across the four games they were moneyline favorites in their last 10 matchups.
• Over their last 10 matchups, the Padres and their opponents combined to hit the over two times (all 10 of the games had set totals).
• The Padres have a 3-7-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Tatis is the bat to watch in the Padres lineup, leading the team in batting average (.347), home runs (8), and RBI (18).
• Tatis' home runs rank him sixth in MLB, and he ranks 20th in RBI.
• Tatis brings a hitting streak of two games into this game. In his last five games he is hitting .300 with two doubles and two RBI.
• Manny Machado is batting .280 with 10 doubles, two home runs and 10 walks.
• Including all major league hitters, Machado ranks 140th in homers and 129th in RBI.
• Machado heads into this game looking for his third game in a row with a hit. In his last five games he is hitting .167 with a double and a walk.
• Xander Bogaerts is hitting .239 with eight doubles and 12 walks.
• Gavin Sheets is hitting .276 with four doubles, three home runs and five walks.

Padres Team Props

Rays Recent Betting Performance

• The Rays have played as underdogs in seven of their past 10 games and won four of those contests.
• In their last 10 games with a total, the Rays and their opponents are 3-6-1 when it comes to hitting the over.
• The Rays have a record of 6-4-0 ATS over their last 10 games.

Rays Recent Stats

Rays Player Insights

• Jonathan Aranda leads the team in batting average with a mark of .321.
• In all of MLB, Aranda is 55th in home runs and 68th in RBI.
• Diaz is hitting .248 with seven doubles, three home runs and six walks.
• Diaz is currently 95th in homers and 68th in RBI in the major leagues.
• Junior Caminero has five home runs, best in the lineup.
• Kameron Misner is batting .333 with seven doubles, a triple, three home runs and five walks.

Rays Team Props

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