Padres vs. Nationals Prediction, Odds, Picks - July 18

Manny Machado and the San Diego Padres will take on James Wood and the Washington Nationals at Nationals Park on Friday at 6:45 p.m. ET, in the first game of a three-game series. Oddsmakers list the Padres as -154 moneyline favorites, while giving the underdog Nationals +129 moneyline odds to win. San Diego is favored on the run line (-1.5). The total is 8.5 runs for this game.

Take a look at everything you need to know from a betting perspective on the Padres-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Padres vs. Nationals Game Information & Odds

• When: Friday, July 18, 2025 at 6:45 p.m. ET
• Where: Nationals Park in Washington D.C.
• How to watch on TV: MASN and SDPA

Padres vs. Nationals Prediction

• Score Prediction: Padres 6, Nationals 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Padres 51%, Nationals 49%

Padres vs. Nationals Betting Insights

• The Padres have entered the game as favorites 49 times this season and won 29, or 59.2%, of those games.
• San Diego has a record of 15-9 in games when oddsmakers favor them by at least -154 on the moneyline.
• The sportsbooks' moneyline implies a 60.6% chance of a victory for the Padres.
• The Nationals have won in 34, or 42.5%, of the 80 contests they have been named as odds-on underdogs this year.
• This year, Washington has won 17 of 46 games when listed as at least +129 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Nationals have a 43.7% chance of pulling out a win.

Padres Recent Betting Performance

• The Padres played as the moneyline favorite for five of their last 10 games, and finished 2-3 in those matchups.
• In their last 10 outings -- all had a set run total -- the Padres and their opponents combined to go over the total four times.
• The Padres' record against the spread is 6-4-0 over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. is batting .269 with 13 doubles, two triples, 16 home runs and 51 walks.
• Tatis ranks 43rd in homers and 85th in RBI among all hitters in baseball.
• Tatis carries a six-game hitting streak into this matchup. During his last 10 games he is batting .343 with two doubles, a triple, a home run, 10 walks and four RBIs.
• Machado has hit 17 home runs with 56 RBI while hitting .292. Those stats all pace his team.
• Machado ranks 31st in homers and 26th in RBI among all hitters in MLB.
• Luis Arraez is hitting .279 with 17 doubles, four triples, five home runs and 18 walks.
• Gavin Sheets is batting .265 with 15 doubles, a triple, 14 home runs and 27 walks.

Padres Team Props

Nationals Recent Betting Performance

• The Nationals have played as underdogs in 10 of their past 10 games and won two of those contests.
• When it comes to hitting the over, the Nationals and their opponents are 8-1-1 in their last 10 games with a total.
• The Nationals have three wins against the spread in their last 10 chances.

Nationals Recent Stats

Nationals Player Insights

• Wood leads the Nationals with 24 long balls and runs batted in, driving in 69.
• In all of the big leagues, Wood ranks eighth in home runs and eighth in RBI.
• C.J. Abrams is hitting .287 to lead the lineup.
• Abrams ranks 82nd in home runs and 146th in RBI among all batters in MLB.
• Luis Garcia has 20 doubles, seven home runs and 18 walks while batting .259.
• Nathaniel Lowe has 14 doubles, two triples, 14 home runs and 34 walks while batting .227.

Nationals Team Props

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