Padres vs. Angels Prediction, Odds, Picks - May 14

Randy Vasquez and Kyle Hendricks are the projected starters when the San Diego Padres and Los Angeles Angels square off on Wednesday at PETCO Park. The favored Padres have -189 moneyline odds against the underdog Angels, who are listed at +157. San Diego is the favorite on the run line (-1.5). The over/under is 8.5 runs for the matchup.

Check out everything you need to know from a betting perspective on the Padres-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Padres' Fernando Tatis Jr. hits walk-off home run vs. Angels

Fernando Tatis Jr. launched a walk-off home run in the San Diego Padres' 6-4 lead over the Los Angeles Angels.

Padres vs. Angels Game Information & Odds

• When: Wednesday, May 14, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and FDSW

Padres vs. Angels Prediction

• Score Prediction: Padres 5, Angels 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Padres 61%, Angels 39%

Padres vs. Angels Betting Insights

• This season, the Padres have won 16 out of the 22 games, or 72.7%, in which they've been favored.
• San Diego has a record of 5-2 when favored by -189 or more by oddsmakers this season.
• The bookmakers' moneyline implies a 65.4% chance of a victory for the Padres.
• The Angels have won in 13, or 39.4%, of the 33 contests they have been named as odds-on underdogs this year.
• Los Angeles has a win-loss record of 2-4 when favored by +157 or worse by oddsmakers this year.
• The Angels have an implied victory probability of 38.9% according to the moneyline set for this matchup.

Padres Recent Betting Performance

• The Padres were the moneyline favorite in five of their last 10 games, and finished 3-2 in those matchups.
• In their last 10 matchups, the Padres and their opponents combined to hit the over on the total six times (all 10 games had set totals).
• The Padres have put together a 7-3-0 record against the spread over their past 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. has gone yard 11 times in the 2025 campaign while driving in 26 runs, both totals that lead the Padres.
• Among all MLB hitters, Tatis is ninth in batting average, 16th in on-base percentage, and seventh in slugging.
• Tatis carries a seven-game hitting streak into this matchup. In his last 10 games he is hitting .238 with two doubles, three home runs, four walks and eight RBIs.
• Manny Machado's .331 batting average paces his team.
• Machado is 160th in homers and 80th in RBI in the majors.
• Machado has 13 straight games with at least one hit. In his last 10 games he is hitting .500 with four doubles, a home run, six walks and seven RBIs.
• Luis Arraez is hitting .287 with four doubles, two triples, three home runs and eight walks.
• Arraez has at least one base hit in two straight games. In his last five games he is batting .320 with a triple and three RBIs.
• Xander Bogaerts is batting .243 with nine doubles, two home runs and 20 walks.

Padres Team Props

Angels Recent Betting Performance

• The Angels have played as underdogs in 10 of their past 10 games and have gone 5-5 in those contests.
• In their last 10 games with a total, the Angels and their opponents have failed to hit the over three times.
• The Angels are 5-5-0 ATS over their last 10 games.

Angels Recent Stats

Angels Player Insights

• Nolan Schanuel leads the team in batting average with a mark of .265.
• Schanuel's home run total puts him 202nd in MLB, and he is 228th in RBI.
• Taylor Ward has been a reliable source of runs this year, leading the lineup with nine home runs and 21 RBI.
• Ward ranks 19th overall in homers and 66th in RBI this year.
• Zach Neto is batting .278 with five doubles, six home runs and five walks.
• Jorge Soler is hitting .221 with eight doubles, six home runs and 13 walks.

Angels Team Props

Padres' Fernando Tatis Jr. hits walk-off home run vs. Angels

Fernando Tatis Jr. launched a walk-off home run in the San Diego Padres' 6-4 lead over the Los Angeles Angels.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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