Mets vs. Nationals Prediction, Odds, Picks - September 21

Juan Soto and the New York Mets take the field against James Wood and the Washington Nationals on Sunday at 1:40 p.m. ET, in the final of a three-game series at Citi Field. The favored Mets have -294 moneyline odds against the underdog Nationals, who are listed at +236. New York (-1.5) is favored on the run line. The total for the game has been set at 8.5 runs.

Here's everything you need from a betting perspective on the Mets-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Nationals vs. Mets Highlights | MLB on FOX

Check out the best moments between the Washington Nationals and New York Mets.

Mets vs. Nationals Game Information & Odds

• When: Sunday, September 21, 2025 at 1:40 p.m. ET
• Where: Citi Field in Queens, New York
• How to watch on TV: WPIX and MASN2

Mets vs. Nationals Prediction

• Score Prediction: Mets 7, Nationals 5
• Total Prediction: Over 8.5 runs
• Win Probabilities: Mets 56%, Nationals 44%

Mets vs. Nationals Betting Insights

• The Mets have entered the game as favorites 110 times this season and won 62, or 56.4%, of those games.
• New York is undefeated in three games this season when favored by -294 or more on the moneyline.
• The Mets have a 74.6% chance to win this game based on the implied probability of the moneyline.
• The Nationals have won in 57, or 41.9%, of the 136 contests they have been named as odds-on underdogs this year.
• Oddsmakers have given Washington the worst odds of winning it has seen this season with a +236 moneyline listed for this contest.
• Oddsmakers have implied with the moneyline set for this matchup that the Nationals have a 29.8% chance of pulling out a win.

Mets Recent Betting Performance

• The Mets were the moneyline favorite in eight of their last 10 games, and they finished 4-4 in those matchups.
• Over their last 10 matchups (all had set totals), the Mets combined with their opponents to hit the over on the total six times.
• The Mets have a 4-6-0 record against the spread over their past 10 games.

Mets Recent Stats

Mets Player Insights

• Soto has gone yard 42 times this season, the highest mark on the Mets, while hitting .266 with 104 RBI.
• Soto's home runs put him seventh in the majors, and he is 10th in RBI.
• Soto has collected a hit in five straight games. In his last five games he is batting .381 with a double, two home runs, two walks and six RBIs.
• Francisco Lindor is hitting .267 with 34 doubles, 27 home runs and 60 walks.
• Lindor is 34th in home runs and 48th in RBI on the season.
• Lindor enters this game looking for his 10th game in a row with a hit. In his last 10 games he is hitting .316 with two doubles, a home run, six walks and two RBIs.
• Pete Alonso has accumulated a team-high batting average of .272 and paces the Mets in runs batted in (122).
• Alonso has at least one base hit in seven straight games. During his last 10 games he is hitting .324 with a double, four home runs, four walks and nine RBIs.
• Brandon Nimmo has 27 doubles, 24 home runs and 49 walks while hitting .260.

Mets Team Props

Nationals Recent Betting Performance

• In 10 games as underdogs over the last 10 matchups, the Nationals have a record of 3-7.
• In their last 10 games with a total, the Nationals and their opponents have failed to hit the over six times.
• The Nationals have three wins against the spread in their last 10 chances.

Nationals Recent Stats

Nationals Player Insights

• C.J. Abrams paces the Nationals with a team-high batting average of .261.
• In all of the majors, Abrams ranks 97th in homers and 125th in RBI.
• Wood been a consistent power bat this season, as he paces his team with 27 home runs and 89 RBI.
• Wood is 34th in home runs and 26th in RBI among all hitters in MLB.
• Luis Garcia is hitting .255 with 28 doubles, a triple, 13 home runs and 26 walks.
• Josh Bell is hitting .232 with 14 doubles, a triple, 20 home runs and 55 walks.

Nationals Team Props

Nationals vs. Mets Highlights | MLB on FOX

Check out the best moments between the Washington Nationals and New York Mets.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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