Guardians vs. White Sox Prediction, Odds, Picks - July 10

Jose Ramirez and the Cleveland Guardians play Miguel Vargas and the Chicago White Sox at Rate Field on Thursday. First pitch is at 7:40 p.m. ET. The Guardians are the favorite in this one, at -122, while the underdog White Sox have +102 odds to upset. Cleveland is the favorite on the run line (-1.5 with +135 odds). The over/under is 8.5 runs for this matchup (with -103 odds on the over and -117 odds to go under).

Check out everything you need from a betting perspective on the Guardians-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Blue Jays vs. White Sox Highlights | MLB on FOX

Check out the best moments between the Toronto Blue Jays and Chicago White Sox.

Guardians vs. White Sox Game Information & Odds

• When: Thursday, July 10, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and CLEG

Guardians vs. White Sox Prediction

• Score Prediction: White Sox 5, Guardians 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Guardians 51%, White Sox 49%

Guardians vs. White Sox Betting Insights

• The Guardians have entered the game as favorites 31 times this season and won 18, or 58.1%, of those games.
• Cleveland has entered 19 games this season favored by -122 or more and is 12-7 in those contests.
• The sportsbooks' moneyline implies a 55% chance of a victory for the Guardians.
• The White Sox have come away with 30 wins in the 91 contests they have been listed as the underdogs in this season.
• Chicago has a win-loss record of 30-58 when favored by +102 or worse by oddsmakers this year.
• Bookmakers have implied with the moneyline set for this matchup that the White Sox have a 49.5% chance of pulling out a win.

Guardians Recent Betting Performance

• In the last 10 games, the Guardians have not been favored on the moneyline.
• Over their last 10 outings, the Guardians and their opponents combined to go over the total four times (all 10 games had set totals).
• The Guardians have a 7-3-0 record against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez has a team-high batting average of .301, while leading the Guardians in home runs (17) and runs batted in (45).
• Ramirez's home runs put him 28th in the majors, and he is 66th in RBI.
• Ramirez carries a three-game hitting streak into this matchup. In his last five games he is batting .333 with a double, three home runs, four walks and six RBIs.
• Steven Kwan has 20 doubles, a triple, six home runs and 30 walks while hitting .292.
• Kwan ranks 196th in homers and 176th in RBI among all hitters in baseball.
• Carlos Santana is hitting .230 with seven doubles, 10 home runs and 41 walks.
• Angel Martinez is batting .238 with 13 doubles, a triple, seven home runs and nine walks.
• Martinez brings a six-game streak with at least one hit into this one. During his last 10 games he is hitting .273 with three doubles, two home runs, three walks and six RBIs.

Guardians Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in eight of their past 10 games and won three of those contests.
• In their last 10 games with a total, the White Sox and their opponents are 2-7-1 when it comes to hitting the over.
• The White Sox have a record of 4-6-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Vargas paces the White Sox with 10 home runs and 34 runs batted in, while posting a team-best batting average of .220.
• Vargas is 114th in home runs and 128th in RBI among all hitters in the big leagues.
• Andrew Benintendi has been a reliable source of runs this year, leading the lineup with 10 home runs and 34 RBI.
• Benintendi is currently 114th in homers and 128th in RBI in the big leagues.
• Chase Meidroth is batting .247 with six doubles, two home runs and 31 walks.
• Lenyn Sosa is batting .272 with 14 doubles, a triple, seven home runs and seven walks.

White Sox Team Props

Blue Jays vs. White Sox Highlights | MLB on FOX

Check out the best moments between the Toronto Blue Jays and Chicago White Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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