Giants vs. Padres Prediction, Odds, Picks - April 29

Logan Webb will start for the San Francisco Giants on Tuesday at PETCO Park against Luis Arraez and the San Diego Padres. First pitch is set for 9:40 p.m. ET in this first game of a two-game series. The Padres are +106 moneyline underdogs in this matchup against the favorite Giants (-125). San Francisco is the favorite on the run line (-1.5 with +145 odds). The game's total has been listed at 7 runs.

Check out everything you need to know from a betting perspective on the Giants-Padres game, regarding the run line, moneyline and total, plus expert picks.

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Heliot Ramos hits a little-league home run in the Giants' 3-2 win over Rangers

Heliot Ramos hit a little-league home run in the San Francisco Giants' 3-2 win over Texas Rangers.

Giants vs. Padres Game Information & Odds

• When: Tuesday, April 29, 2025 at 9:40 p.m. ET
• Where: PETCO Park in San Diego, California
• How to watch on TV: SDPA and NBCS-BA

Giants vs. Padres Prediction

• Score Prediction: Padres 4, Giants 3
• Total Prediction: Under 7 runs
• Win Probabilities: Giants 52%, Padres 48%

Giants vs. Padres Betting Insights

• The Giants have been favorites in 17 games this season and won 12 (70.6%) of those contests.
• San Francisco has a record of 9-5 in games when sportsbooks favor them by at least -125 on the moneyline.
• The oddsmakers' moneyline implies a 55.6% chance of a victory for the Giants.
• The Padres have been chosen as underdogs in 13 games this year and have walked away with the win six times (46.2%) in those games.
• This season, San Diego has been victorious four times in nine chances when named as an underdog of at least +106 or worse on the moneyline.
• The moneyline set for this matchup implies the Padres have a 48.5% chance of coming away with a victory in the contest.

Giants Recent Betting Performance

• The Giants went 6-3 across the nine games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups (all had set totals), the Giants combined with their opponents to go over the total two times.
• The Giants have gone 2-8-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee's .324 average leads the Giants this year. His resume also includes three homers and driven in 16 RBI.
• Lee ranks 101st in home runs and 40th in RBI among all batters in MLB.
• Lee brings a hitting streak of five games into this matchup. In his last five games he is batting .368 with a double, two walks and an RBI.
• Wilmer Flores has hit seven home runs with 28 RBI. Both are team-highs.
• Including all major league hitters, Flores is 13th in home runs and first in RBI.
• Matt Chapman is batting .214 with four doubles, five home runs and 26 walks.
• Michael Yastrzemski has six doubles, four home runs and 15 walks while hitting .277.
• Yastrzemski takes a two-game streak with at least one hit into this one. In his last five games he is hitting .250 with a home run, a walk and two RBI.

Giants Team Props

Padres Recent Betting Performance

• The Padres have played as underdogs in six of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Padres and their opponents have combined to hit the over two times.
• The Padres have a record of 2-8-0 ATS over their last 10 games.

Padres Recent Stats

Padres Player Insights

• Fernando Tatis Jr. paces the Padres with eight home runs and 18 runs batted in, while recording a team-high batting average of .346.
• Tatis' home run total puts him eighth in the majors, and he is 24th in RBI.
• Tatis brings a hitting streak of three games into this game. During his last five outings he is hitting .333 with two doubles, a walk and an RBI.
• Manny Machado is batting .272 with 10 doubles, two home runs and 10 walks.
• Machado is 145th in home runs and 122nd in RBI among all MLB hitters this season.
• Arraez is batting .287 with three doubles, three home runs and five walks.
• Xander Bogaerts has eight doubles and 13 walks while batting .242.

Padres Team Props

Heliot Ramos hits a little-league home run in the Giants' 3-2 win over Rangers

Heliot Ramos hit a little-league home run in the San Francisco Giants' 3-2 win over Texas Rangers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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