Giants vs. Diamondbacks Prediction, Odds, Picks - September 10

Rafael Devers and the San Francisco Giants will try to find success against Eduardo Rodriguez when he takes the mound for the Arizona Diamondbacks on Wednesday at 3:45 p.m. ET. The favored Giants have -144 moneyline odds to win against the underdog Diamondbacks, who are listed at +121. San Francisco is the favorite on the run line (-1.5 with +154 odds). The total is 7.5 runs for this game.

Take a look at everything you need to know from a betting perspective on the Giants-Diamondbacks game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Giants Highlights | MLB on FOX

Check out the best moments between Arizona Diamondbacks and the San Francisco Giants.

Giants vs. Diamondbacks Game Information & Odds

• When: Wednesday, September 10, 2025 at 3:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and ARID

Giants vs. Diamondbacks Prediction

• Score Prediction: Giants 6, Diamondbacks 5
• Total Prediction: Over 7.5 runs
• Win Probabilities: Giants 53%, Diamondbacks 47%

Giants vs. Diamondbacks Betting Insights

• This season, the Giants have been favored 85 times and won 46, or 54.1%, of those games.
• This season San Francisco has won 30 of its 53 games, or 56.6%, when favored by at least -144 on the moneyline.
• The sportsbooks' moneyline implies a 59% chance of a victory for the Giants.
• The Diamondbacks have been victorious in 29, or 47.5%, of the 61 contests they have been chosen as underdogs in this season.
• This season, Arizona has come away with a win 16 times in 26 chances when named as an underdog of at least +121 or worse on the moneyline.
• The moneyline set for this matchup implies the Diamondbacks have a 45.2% chance of coming away with a victory in the contest.

Giants Recent Betting Performance

• The Giants were favored on the moneyline for seven of their last 10 games, and they finished 6-1 in those matchups.
• Over their last 10 outings (all had set totals), the Giants combined with their opponents to go over the run total seven times.
• The Giants are 8-2-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• The Giants' best power option comes in the form of Devers and his 31-dinger 100-RBI season, both team highs.
• Among all hitters in MLB, Devers ranks 11th in homers and seventh in RBI.
• Jung Hoo Lee is batting .271 to lead his team.
• Lee is 226th in home runs and 145th in RBI on the year.
• Lee enters this game looking for his third game in a row with a hit. During his last five outings he is batting .500 with a triple, a home run and three RBIs.
• Willy Adames is hitting .230 with 19 doubles, two triples, 28 home runs and 68 walks.
• Adames will look to build on his two-game hitting in this game. In his last five games he is batting .222 with a double, two home runs, two walks and five RBIs.
• Heliot Ramos is hitting .265 with 23 doubles, a triple, 17 home runs and 46 walks.

Giants Team Props

Diamondbacks Recent Betting Performance

• The Diamondbacks have played as underdogs in six of their past 10 games and have gone 3-3 in those contests.
• In their last 10 games with a total, the Diamondbacks and their opponents have combined to hit the over five times.
• The Diamondbacks are 6-4-0 ATS over their last 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Geraldo Perdomo has driven in a team-high 91 runs batted in.
• Among all hitters in MLB, Perdomo's home run total ranks 96th and his RBI tally ranks 15th.
• Corbin Carroll's 30 home runs are a team-high total.
• Carroll is 12th in home runs and 48th in RBI among all MLB hitters this season.
• Ketel Marte has accumulated a team-high batting average of .283.
• Gabriel Moreno is hitting .283 with 11 doubles, a triple, eight home runs and 18 walks.

Diamondbacks Team Props

Diamondbacks vs. Giants Highlights | MLB on FOX

Check out the best moments between Arizona Diamondbacks and the San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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