Dodgers vs. Giants Prediction, Odds, Picks - September 18

Mookie Betts and the Los Angeles Dodgers will play Rafael Devers and the San Francisco Giants on Thursday at Dodger Stadium, at 10:10 p.m. ET. The Giants have been listed as +143 moneyline underdogs in this matchup against the favored Dodgers (-172). Los Angeles is a 1.5-run favorite (at +129 odds). The total for the contest has been listed at 7.5 runs.

Here's everything you need from a betting perspective on the Dodgers-Giants game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Dodgers vs Orioles Highlights | MLB on FOX

Check out the best highlights between the Los Angeles Dodgers and the Baltimore Orioles.

Dodgers vs. Giants Game Information & Odds

• When: Thursday, September 18, 2025 at 10:10 p.m. ET
• Where: Dodger Stadium in Los Angeles, California
• How to watch on TV: MLB Network, SportsNet LA, and NBCS-BA

Dodgers vs. Giants Prediction

• Score Prediction: Dodgers 5, Giants 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Dodgers 56%, Giants 44%

Dodgers vs. Giants Betting Insights

• This season, the Dodgers have been favored 134 times and won 76, or 56.7%, of those games.
• This season Los Angeles has won 45 of its 75 games, or 60%, when favored by at least -172 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Dodgers have a 63.2% chance to win.
• The Giants have come away with 30 wins in the 64 contests they have been listed as the underdogs in this season.
• This season, San Francisco has come away with a win one time in nine chances when named as an underdog of at least +143 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Giants have a 41.2% chance of pulling out a win.

Dodgers Recent Betting Performance

• The Dodgers have a 6-3 record over the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Dodgers and their opponents combined to go over the total five times.
• The Dodgers' ATS record is 8-2-0 over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Shohei Ohtani has gone yard 51 times in the 2025 campaign while knocking in 95 runs, both totals that lead the Dodgers.
• Of all batters in baseball, Ohtani ranks third in homers and 15th in RBI.
• Ohtani has collected a hit in five games in a row. In his last five games he is batting .348 with a double, three home runs, three walks and three RBIs.
• Betts has 22 doubles, two triples, 19 home runs and 57 walks while batting .261.
• Betts ranks 81st in home runs and 48th in RBI among all MLB hitters this season.
• Freddie Freeman leads the Dodgers with a team-best batting average of .295.
• Andy Pages is batting .278 with 25 doubles, a triple, 25 home runs and 28 walks.
• Pages has recorded at least one hit in four games in a row. During his last five outings he is hitting .421 with two doubles, a home run, a walk and an RBI.

Dodgers Team Props

Giants Recent Betting Performance

• The Giants have played as underdogs in six of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Giants and their opponents have combined to hit the over five times.
• Over their last 10 games, the Giants are 6-4-0 against the spread.

Giants Recent Stats

Giants Player Insights

• Devers leads the Giants with 31 long balls and runs batted in, driving in 103.
• Among all hitters in the majors, Devers is 14th in homers and eighth in RBI.
• Jung Hoo Lee's .262 batting average leads his team.
• Lee ranks 241st among all hitters in the big leagues in homers, and 145th in RBI.
• Willy Adames is hitting .227 with 20 doubles, two triples, 28 home runs and 73 walks.
• Matt Chapman has 20 doubles, two triples, 21 home runs and 66 walks while hitting .235.

Giants Team Props

Dodgers vs Orioles Highlights | MLB on FOX

Check out the best highlights between the Los Angeles Dodgers and the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Los Angeles Dodgers

San Francisco Giants