Dodgers vs. Giants Prediction, Odds, Picks - September 12

The San Francisco Giants and Drew Gilbert take the field in the first game of a three-game series against Mookie Betts and the Los Angeles Dodgers on Friday at Oracle Park. Oddsmakers list the Dodgers as -150 favorites on the moneyline, while giving the underdog Giants +126 moneyline odds to win. Los Angeles is favored on the run line (-1.5 with +114 odds). A 7.5-run total has been set for this matchup.

Check out everything you need to know from a betting perspective on the Dodgers-Giants game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Diamondbacks vs. Giants Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and the San Francisco Giants.

Dodgers vs. Giants Game Information & Odds

• When: Friday, September 12, 2025 at 10:15 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: MLB Network, NBCS-BA, and SportsNet LA

Dodgers vs. Giants Prediction

• Score Prediction: Giants 6, Dodgers 5
• Total Prediction: Over 7.5 runs
• Win Probabilities: Dodgers 51%, Giants 49%

Dodgers vs. Giants Betting Insights

• The Dodgers have entered the game as favorites 129 times this season and won 74, or 57.4%, of those games.
• Los Angeles is 56-41 this season when entering a game favored by -150 or more on the moneyline.
• The Dodgers have a 60% chance to win this game based on the implied probability of the moneyline.
• The Giants have been chosen as underdogs in 59 games this year and have walked away with the win 28 times (47.5%) in those games.
• San Francisco has a win-loss record of 6-11 when favored by +126 or worse by bookmakers this year.
• The moneyline set for this matchup implies the Giants have a 44.2% chance of coming away with a victory in the contest.

Dodgers Recent Betting Performance

• The Dodgers went 5-5 over the 10 games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings, the Dodgers and their opponents combined to go over the run total three times (all 10 games had set totals).
• The Dodgers have put together a 4-6-0 record against the spread over their past 10 games.

Dodgers Recent Stats

Dodgers Player Insights

• Shohei Ohtani has gone yard 48 times in the 2025 campaign while driving in 92 runs, both totals that lead the Dodgers.
• Among all hitters in baseball, Ohtani ranks third in home runs and 16th in RBI.
• Ohtani has collected a hit in five straight games. In his last five games he is hitting .375 with a double, two home runs, six walks and five RBIs.
• Betts has 21 doubles, two triples, 18 home runs and 54 walks while hitting .260.
• Betts is 91st in homers and 49th in RBI on the year.
• Betts heads into this game looking for his eighth game in a row with a hit. In his last 10 outings he is batting .395 with three doubles, a triple, four home runs, a walk and 15 RBIs.
• Freddie Freeman has racked up a team-high batting average of .292.
• Andy Pages is batting .273 with 23 doubles, a triple, 24 home runs and 27 walks.
• Pages brings a two-game streak with at least one hit into this one. In his last five games he is hitting .294 with a double and an RBI.

Dodgers Team Props

Giants Recent Betting Performance

• Over the past 10 games, the Giants have been underdogs twice and split those games 1-1.
• When it comes to hitting the over, the Giants and their opponents are 6-4-0 in their last 10 games with a total.
• The Giants have a record of 8-2-0 ATS over their last 10 games.

Giants Recent Stats

Giants Player Insights

• Rafael Devers has a team-leading 31 home runs and has driven in 102 runs.
• Devers' home run total places him 11th in MLB, and he ranks seventh in RBI.
• Jung Hoo Lee's .269 batting average is a team-high mark.
• Lee ranks 228th overall in homers and 140th in RBI this season.
• Willy Adames is hitting .229 with 19 doubles, two triples, 28 home runs and 69 walks.
• Matt Chapman is hitting .243 with 19 doubles, two triples, 21 home runs and 63 walks.

Giants Team Props

Diamondbacks vs. Giants Highlights | MLB on FOX

Check out the best moments between the Arizona Diamondbacks and the San Francisco Giants.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

San Francisco Giants

Los Angeles Dodgers