Diamondbacks vs. Cardinals Prediction, Odds, Picks - May 23

Alec Burleson and the St. Louis Cardinals are ready for a matchup with Geraldo Perdomo and the Arizona Diamondbacks on Friday at 8:15 p.m. ET. Bookmakers list the Diamondbacks as -113 favorites on the moneyline, while giving the underdog Cardinals -106 moneyline odds. Arizona (-1.5) is the favorite on the run line. An 8-run over/under is set for the game.

Here's everything you need from a betting perspective on the Diamondbacks-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Diamondbacks vs. Cardinals Game Information & Odds

• When: Friday, May 23, 2025 at 8:15 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: Apple TV+

Diamondbacks vs. Cardinals Prediction

• Score Prediction: Cardinals 5, Diamondbacks 4
• Total Prediction: Over 8 runs
• Win Probabilities: Diamondbacks 55%, Cardinals 45%

Diamondbacks vs. Cardinals Betting Insights

• The Diamondbacks have been favorites in 32 games this season and won 18 (56.2%) of those contests.
• Arizona has a record of 17-14 in games when sportsbooks favor them by at least -113 on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Diamondbacks have a 53.1% chance to win.
• The Cardinals have been underdogs in 33 games this season and have come away with the win 18 times (54.5%) in those contests.
• This year, St. Louis has won 15 of 30 games when listed as at least -106 or worse on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Cardinals have a 51.5% chance of pulling out a win.

Diamondbacks Recent Betting Performance

• The Diamondbacks were favored on the moneyline for six of their last 10 games, and they finished 4-2 in those matchups.
• Over their last 10 outings, the Diamondbacks and their opponents combined to go over the total four times (all 10 games had set totals).
• The Diamondbacks have put together a 3-7-0 record against the spread over their past 10 games.

Diamondbacks Recent Stats

Diamondbacks Player Insights

• Corbin Carroll's 15 home runs in 2025 are the most on the Diamondbacks. He's also driven in 34 runs while hitting .278.
• Carroll's home runs rank him fifth in MLB, and he ranks 14th in RBI.
• Carroll carries a three-game hitting streak into this matchup. In his last five games he is batting .190 with a triple, a home run, three walks and three RBIs.
• Perdomo has a club-best .306 batting average.
• Perdomo ranks 87th in homers and ninth in RBI among all hitters in the majors.
• Perdomo carries a nine-game streak with at least one hit into this contest. During his last 10 outings he is hitting .333 with five doubles, a home run, four walks and seven RBIs.
• Josh Naylor has 12 doubles, five home runs and 19 walks while hitting .290.
• Eugenio Suarez has capitalized on opportunities as he paces his team with 38 runs batted in.

Diamondbacks Team Props

Cardinals Recent Betting Performance

• In seven games as underdogs over the last 10 matchups, the Cardinals have a record of 5-2.
• In their last 10 games with a total, the Cardinals and their opponents have combined to hit the over four times.
• The Cardinals have a record of 7-3-0 ATS over their last 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Lars Nootbaar has racked up a team-high seven home runs.
• Nootbaar's home run total puts him 70th in the majors, and he ranks 67th in RBI.
• Brendan Donovan's .323 batting average is a team-high mark.
• Donovan is 180th overall in homers and 91st in RBI this season.
• Nolan Arenado is hitting .242 with 10 doubles, five home runs and 17 walks.
• Willson Contreras has driven in the most runs for the Cardinals with 28 runs batted in.

Cardinals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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