Cubs vs. Mets Prediction, Odds, Picks - September 25

Nico Hoerner and the Chicago Cubs hit the field on Thursday at Wrigley Field against Nolan McLean, who is starting for the New York Mets. First pitch is at 7:40 p.m. ET for the final game of a three-game series. Bookmakers list the Cubs as -119 favorites on the moneyline, while giving the underdog Mets -101 moneyline odds to win. New York is favored on the run line (-1.5 with +172 odds). The total is 7 runs for this matchup (with -120 odds to hit the over and -100 odds on the under).

Check out everything you need to know from a betting perspective on the Cubs-Mets game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Mets vs. Cubs Highlights | MLB on FOX

Enjoy the best moments between the New York Mets and the Chicago Cubs.

Cubs vs. Mets Game Information & Odds

• When: Thursday, September 25, 2025 at 7:40 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MLB Network, MARQ, and SNY

Cubs vs. Mets Prediction

• Score Prediction: Cubs 5, Mets 4
• Total Prediction: Over 7 runs
• Win Probabilities: Cubs 55%, Mets 45%

Cubs vs. Mets Betting Insights

• The Cubs have entered the game as favorites 113 times this season and won 71, or 62.8%, of those games.
• This season Chicago has won 67 of its 99 games, or 67.7%, when favored by at least -119 on the moneyline.
• The implied probability of a win from the Cubs, based on the moneyline, is 54.3%.
• The Mets have been victorious in 19, or 40.4%, of the 47 contests they have been chosen as underdogs in this season.
• This season, New York has come away with a win 10 times in 30 chances when named as an underdog of at least -101 or longer on the moneyline.
• The Mets have an implied victory probability of 50.2% according to the moneyline set by sportsbooks for this matchup.

Cubs Recent Betting Performance

• The Cubs went 4-2 over the six games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups, the Cubs and their opponents combined to hit the over on the total four times (all 10 games had set totals).
• The Cubs have put together a 6-4-0 record against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• The Cubs best hitter thus far this season is Hoerner, who's hitting at a team-leading .301 rate along with six homers and 60 RBI.
• Of all hitters in baseball, Hoerner ranks 279th in home runs and 124th in RBI.
• Hoerner carries a two-game hitting streak into this matchup. During his last five outings he is hitting .318 with a walk and an RBI.
• Pete Crow-Armstrong has 37 doubles, four triples, 29 home runs and 29 walks while batting .244.
• Including all major league batters, Crow-Armstrong ranks 30th in homers and 27th in RBI.
• Ian Happ has 31 doubles, 23 home runs and 86 walks while batting .241.
• Happ will look to build on his three-game hitting in this game. During his last five outings he is batting .238 with three doubles, a walk and five RBIs.
• Michael Busch's 31 home runs are a team-high mark.

Cubs Team Props

Mets Recent Betting Performance

• The Mets have been underdogs twice in the last 10 games and split those matchups 1-1.
• In their last 10 games with a total, the Mets and their opponents have combined to hit the over five times.
• The Mets are 5-5-0 ATS over their last 10 games.

Mets Recent Stats

Mets Player Insights

• Juan Soto has hit a team-best 43 home runs.
• Among all hitters in the big leagues, Soto ranks seventh in homers and 10th in RBI.
• Soto takes a hitting streak of eight games into this game. In his last 10 games he is hitting .325 with two doubles, four home runs, six walks and nine RBIs.
• Francisco Lindor is batting .267 with 34 doubles, 29 home runs and 60 walks.
• Lindor is 30th in homers and 41st in RBI among all hitters in the big leagues.
• Pete Alonso leads the Mets in runs batted in (123) and has racked up a team-best batting average of .271.
• Brandon Nimmo has 27 doubles, 25 home runs and 49 walks while hitting .261.

Mets Team Props

Mets vs. Cubs Highlights | MLB on FOX

Enjoy the best moments between the New York Mets and the Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Chicago Cubs

New York Mets