Cardinals vs. White Sox Prediction, Odds, Picks - June 17

Brendan Donovan and the St. Louis Cardinals will play Chase Meidroth and the Chicago White Sox on Tuesday at Rate Field, at 7:40 p.m. ET. The Cardinals are favored in this one, at -133, while the underdog White Sox have +112 odds to win. St. Louis is the run-line favorite (-1.5). The matchup's total is listed at 9 runs.

Here is everything you need to know from a betting perspective on the Cardinals-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. White Sox Game Information & Odds

• When: Tuesday, June 17, 2025 at 7:40 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and FDSMW

Cardinals vs. White Sox Prediction

• Score Prediction: Cardinals 5, White Sox 4
• Total Prediction: Under 9 runs
• Win Probabilities: Cardinals 52%, White Sox 48%

Cardinals vs. White Sox Betting Insights

• This season, the Cardinals have won 15 out of the 31 games, or 48.4%, in which they've been favored.
• St. Louis has a record of 6-4 in games when oddsmakers favor them by at least -133 on the moneyline.
• The moneyline for this contest implies a 57.1% chance of a victory for the Cardinals.
• The White Sox have been victorious in 23, or 31.9%, of the 72 contests they have been chosen as underdogs in this season.
• This season, Chicago has been victorious 23 times in 68 chances when named as an underdog of at least +112 or longer on the moneyline.
• The moneyline set for this matchup implies the White Sox have a 47.2% chance of walking away with the win.

Cardinals Recent Betting Performance

• The Cardinals went 1-4 over the five games they were moneyline favorites in their last 10 matchups.
• In their last 10 matchups (all had set totals), the Cardinals combined with their opponents to go over the run total four times.
• The Cardinals' record against the spread is 6-4-0 over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Donovan's .313 average leads the Cardinals this year. His resume also includes four homers and driven in 26 RBI.
• Donovan's home runs place him 202nd in the majors, and he ranks 125th in RBI.
• Nolan Arenado is batting .243 with 11 doubles, a triple, eight home runs and 21 walks.
• Arenado is 95th in homers and 56th in RBI on the year.
• Arenado enters this game looking for his seventh game in a row with a hit. During his last 10 games he is batting .333 with a double, a home run, a walk and five RBIs.
• Willson Contreras leads the Cardinals with nine home runs and 45 runs batted in.
• Lars Nootbaar is hitting .226 with 12 doubles, eight home runs and 39 walks.

Cardinals Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won four of those contests.
• When it comes to hitting the over, the White Sox and their opponents are 4-6-0 in their last 10 games with a total.
• The White Sox are 7-3-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Miguel Vargas leads the White Sox with 10 home runs and 31 runs batted in, while posting a team-high batting average of .242.
• In all of the majors, Vargas is 59th in home runs and 88th in RBI.
• Vargas has collected a hit in five games in a row. In his last five games he is hitting .350 with three doubles, a triple, a home run, two walks and two RBIs.
• Meidroth is hitting .282 with five doubles, two home runs and 23 walks.
• Among all MLB hitters, Meidroth ranks 266th in home runs and 306th in RBI.
• Andrew Benintendi has nine doubles, a triple, six home runs and 15 walks while batting .235.
• Luis Robert is hitting .194 with eight doubles, six home runs and 26 walks.

White Sox Team Props

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