Cardinals vs. Nationals Prediction, Odds, Picks - July 10

Brendan Donovan and the St. Louis Cardinals will try to defeat James Wood and the Washington Nationals when the teams meet on Thursday at 7:45 p.m. ET. The favored Cardinals have -144 moneyline odds to win against the underdog Nationals, who are listed at +121. St. Louis is the favorite on the run line (-1.5 with +143 odds). The total is 9 runs for the contest.

Here's everything you need to know from a betting perspective on the Cardinals-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Nationals vs. Cardinals Highlights | MLB on FOX

Check out the best moments between Washington Nationals and St. Louis Cardinals.

Cardinals vs. Nationals Game Information & Odds

• When: Thursday, July 10, 2025 at 7:45 p.m. ET
• Where: Busch Stadium in St. Louis, Missouri
• How to watch on TV: FDSMW and MASN

Cardinals vs. Nationals Prediction

• Score Prediction: Cardinals 5, Nationals 4
• Total Prediction: Over 9 runs
• Win Probabilities: Cardinals 56%, Nationals 44%

Cardinals vs. Nationals Betting Insights

• The Cardinals have won 23, or 56.1%, of the 41 games they've played as favorites this season.
• St. Louis is 8-2 this season when entering a game favored by -144 or more on the moneyline.
• The moneyline for this contest implies a 59% chance of a victory for the Cardinals.
• The Nationals have won in 34, or 44.7%, of the 76 contests they have been named as odds-on underdogs this year.
• This year, Washington has won 19 of 49 games when listed as at least +121 or worse on the moneyline.
• The moneyline set for this matchup implies the Nationals have a 45.2% chance of coming away with a victory in the contest.

Cardinals Recent Betting Performance

• The Cardinals were favored on the moneyline in five of their last 10 games, and they went 3-2 in those matchups.
• Over their last 10 matchups -- all had a set run total -- the Cardinals and their opponents combined to hit the over on the total five times.
• The Cardinals have a 6-4-0 record against the spread over their past 10 games.

Cardinals Recent Stats

Cardinals Player Insights

• Donovan's .294 average leads the Cardinals this year. His resume also includes eight homers and driven in 34 RBI.
• Of all hitters in the majors, Donovan's home run total ranks him 145th, and his RBI tally ranks him 128th.
• Nolan Arenado is batting .244 with 13 doubles, a triple, 10 home runs and 24 walks.
• Including all MLB hitters, Arenado ranks 114th in homers and 85th in RBI.
• Lars Nootbaar has launched a team-best 12 home runs.
• Nootbaar has at least one base hit in two straight games. During his last five outings he is batting .278 with a double, a home run, a walk and two RBIs.
• Alec Burleson has 15 doubles, 11 home runs and 19 walks while hitting .290.
• Burleson takes a two-game streak with at least one hit into this one. During his last five outings he is hitting .278 with a double, a home run, three walks and three RBIs.

Cardinals Team Props

Nationals Recent Betting Performance

• In nine games as underdogs over the last 10 matchups, the Nationals have a record of 3-6.
• In their last 10 games with a total, the Nationals and their opponents have combined to hit the over nine times.
• The Nationals have won four of their last 10 games against the spread.

Nationals Recent Stats

Nationals Player Insights

• Wood paces the Nationals in home runs (24), runs batted in (69) and has recorded a team-best batting average of .287.
• Among all hitters in MLB, Wood's home run total is eighth and his RBI tally ranks eighth.
• Wood carries a three-game hitting streak into this matchup. In his last five games he is hitting .167 with a home run, a walk and two RBIs.
• C.J. Abrams' .287 batting average is a team-high mark.
• Abrams ranks 74th overall in homers and 147th in RBI this year.
• Luis Garcia is batting .266 with 19 doubles, seven home runs and 17 walks.
• Nathaniel Lowe is hitting .235 with 14 doubles, two triples, 14 home runs and 33 walks.

Nationals Team Props

Nationals vs. Cardinals Highlights | MLB on FOX

Check out the best moments between Washington Nationals and St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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