Brewers vs. Cardinals Prediction, Odds, Picks - September 12

The Milwaukee Brewers and Jackson Chourio will take the field against Lars Nootbaar and the St. Louis Cardinals at American Family Field on Friday, with the first pitch at 8:10 p.m. ET. The favored Brewers have -187 moneyline odds to win against the underdog Cardinals, who are listed at +154. Milwaukee is favored on the run line (-1.5 with +109 odds). An 8-run total has been set for this matchup.

Check out everything you need from a betting perspective on the Brewers-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Brewers vs. Cardinals Game Information & Odds

• When: Friday, September 12, 2025 at 8:10 p.m. ET
• Where: American Family Field in Milwaukee, Wisconsin
• How to watch on TV: FDSWI and FDSMW

Brewers vs. Cardinals Prediction

• Score Prediction: Brewers 5, Cardinals 3
• Total Prediction: Under 8 runs
• Win Probabilities: Brewers 60%, Cardinals 40%

Brewers vs. Cardinals Betting Insights

• The Brewers have won 53, or 63.9%, of the 83 games they've played as favorites this season.
• This season Milwaukee has won 12 of its 14 games, or 85.7%, when favored by at least -187 on the moneyline.
• The sportsbooks' moneyline implies a 65.2% chance of a victory for the Brewers.
• The Cardinals have won in 38, or 47.5%, of the 80 contests they have been named as odds-on underdogs this year.
• This year, St. Louis has won two of 12 games when listed as at least +154 or worse on the moneyline.
• The moneyline set for this matchup implies the Cardinals have a 39.4% chance of walking away with the win.

Brewers Recent Betting Performance

• The Brewers were the moneyline favorite for eight of their last 10 games, and went 3-5 in those matchups.
• Over their last 10 matchups -- all had a set run total -- the Brewers and their opponents combined to hit the over on the total five times.
• The Brewers are 4-6-0 against the spread over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• Brice Turang has 25 doubles, two triples, 18 home runs and 56 walks while batting .289.
• Including all MLB hitters, Turang ranks 14th in batting average, 27th in on-base percentage, and 64th in slugging.
• William Contreras is batting .263 with 26 doubles, 17 home runs and 79 walks.
• Contreras is 99th in homers and 64th in RBI on the season.
• Christian Yelich has racked up a team-best 27 home runs and 93 runs batted in.
• Chourio has 33 doubles, four triples, 20 home runs and 25 walks while hitting .278.
• Chourio is riding a four-game hitting streak into this one. During his last five outings he is hitting .273 with two doubles, two home runs, a walk and three RBIs.

Brewers Team Props

Cardinals Recent Betting Performance

• In six games over the last 10 matchups when set as underdogs by bookmakers, the Cardinals had a record of 2-4.
• The Cardinals and their opponents have combined to hit the over four times in their last 10 games with a total.
• The Cardinals have three wins against the spread in their last 10 chances.

Cardinals Recent Stats

Cardinals Player Insights

• Alec Burleson paces the Cardinals with a team-high batting average of .282.
• Burleson ranks 99th in home runs and 94th in RBI among all hitters in the big leagues.
• Willson Contreras has been a reliable source of runs this year, leading the lineup with 20 home runs and 78 RBI.
• Among all MLB hitters, Willson Contreras ranks 69th in homers and 40th in RBI.
• Masyn Winn is batting .253 with 27 doubles, nine home runs and 34 walks.
• Nootbaar is batting .240 with 22 doubles, a triple, 13 home runs and 56 walks.

Cardinals Team Props

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