Angels vs. Pirates Prediction, Odds, Picks - April 22

Mike Trout and the Los Angeles Angels take on Oneil Cruz and the Pittsburgh Pirates on Tuesday at 9:38 p.m. ET in the first game of a three-game series. The Pirates are +156 moneyline underdogs for this matchup against the favored Angels (-188). Los Angeles is favored on the run line (-1.5). An 8.5-run over/under is listed in this game.

Take a look at everything you need from a betting perspective on the Angels-Pirates game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Angels Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Los Angeles Angels.

Angels vs. Pirates Game Information & Odds

• When: Tuesday, April 22, 2025 at 9:38 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and SportsNet PT

Angels vs. Pirates Prediction

• Score Prediction: Angels 4, Pirates 3
• Total Prediction: Under 8.5 runs
• Win Probabilities: Angels 57%, Pirates 43%

Angels vs. Pirates Betting Insights

• The Angels have been favorites in five games this season and won three (60%) of those contests.
• Los Angeles has not entered a game this season as bigger favorites on the moneyline than the -188 odds on them winning this game.
• The moneyline for this contest implies a 65.3% chance of a victory for the Angels.
• The Pirates have been victorious in three, or 25%, of the 12 contests they have been chosen as underdogs in this season.
• Pittsburgh has yet to play a game this season with longer moneyline odds than +156.
• The Pirates have an implied victory probability of 39.1% according to the moneyline set by oddsmakers for this matchup.

Angels Recent Betting Performance

• The Angels have been named the moneyline favorite by oddsmakers only two times over the last 10 games, and split those matchups.
• In their last 10 outings, the Angels and their opponents combined to hit the over on the run total three times (all 10 games had set totals).
• The Angels have gone 5-5-0 against the spread over their past 10 games.

Angels Recent Stats

Angels Player Insights

• Trout paces the Angels in home runs (eight) and runs batted in (16).
• Including all MLB batters, Trout ranks 150th in batting average, 121st in on-base percentage, and 30th in slugging.
• Nolan Schanuel is hitting .273 with four doubles, a triple, two home runs and eight walks.
• Of all MLB hitters, Schanuel ranks 118th in homers and 161st in RBI.
• Kyren Paris has a double, a triple, five home runs and five walks while batting .288.
• Taylor Ward is batting .216 with four doubles, five home runs and four walks.

Angels Team Props

Pirates Recent Betting Performance

• The Pirates have played as underdogs four times over their past 10 games and lost each of those contests.
• In their last 10 games with a total, the Pirates and their opponents have failed to hit the over seven times.
• Over their last 10 games, the Pirates are 3-7-0 against the spread.

Pirates Recent Stats

Pirates Player Insights

• Cruz has managed a team-leading five home runs and has driven in 11 runs.
• Among all hitters in the majors, Cruz is 25th in home runs and 72nd in RBI.
• Ke'Bryan Hayes is hitting .211 with a double, a triple, a home run and seven walks.
• Among all major league batters, Hayes ranks 173rd in homers and 116th in RBI.
• Enmanuel Valdez is hitting .229 with three doubles, two triples, a home run and eight walks.
• Isiah Kiner-Falefa paces the Pirates with a .268 batting average.

Pirates Team Props

Giants vs. Angels Highlights | MLB on FOX

Check out the best moments between the San Francisco Giants and the Los Angeles Angels.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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