USC vs. Colorado Prediction, Odds, Picks - September 30

Updated Sep. 29, 2023 9:05 a.m. ET

Data Skrive

The No. 8 USC Trojans (4-0), who have college football's third-ranked passing offense, play the Colorado Buffaloes (3-1) and their fifth-ranked passing attack on Saturday, September 30, 2023. The Trojans are heavy, 21.5-point favorites. The total is 73.5 points for this game.

The Trojans beat the Arizona State Sun Devils, 42-28, in their last contest. The Buffaloes lost to the Oregon Ducks, 42-6, in their most recent game.

USC vs. Colorado Game Information & Odds

When: Saturday, September 30, 2023 at 12:00 PM ET
Location: Folsom Field in Boulder, Colorado
TV: FOX
Live boxscore on FOX Sports

USC vs Colorado Betting Information updated as of September 29, 2023, 8:45 AM ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-21.5 (-110)	-1421	+806	73.5	-110	-110

USC vs. Colorado Prediction

Pick ATS: Colorado (+21.5)
Pick OU: Under (73.5)
Prediction: USC 38, Colorado 32

Learn more about the USC Trojans vs. the Colorado Buffaloes game on FOX Sports!

USC vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the game is Trojans 48, Buffaloes 26.
The Trojans have a 93.4% chance to win this game based on the moneyline's implied probability. The Buffaloes have an 11.0% implied probability.
USC has won two games against the spread this season.
Colorado has won two games against the spread this season.

USC vs. Colorado: Head-to-Head

In their last two head-to-head meetings, USC has taken down Colorado two times.
In those matchups versus Colorado, the Trojans have covered two times while outpacing the total on one occasion.
Over their last two head-to-head contests, USC has put up 92 points, while Colorado has compiled 31.

USC vs. Colorado: 2023 Stats Comparison

	USC	Colorado
Off. Points per Game (Rank)	55.0 (1)	32.5 (54)
Def. Points per Game (Rank)	20.0 (46)	33.3 (110)
Turnovers Allowed (Rank)	2 (3)	4 (30)
Turnovers Forced (Rank)	6 (54)	8 (18)

USC 2023 Key Players

Name	Position	Stats
Caleb Williams	QB	1,200 YDS (73.5%) / 15 TD / 0 INT 71 RUSH YDS / 3 RUSH TD / 17.8 RUSH YPG
Brenden Rice	WR	12 REC / 257 YDS / 5 TD / 64.3 YPG
Tahj Washington	WR	10 REC / 278 YDS / 4 TD / 69.5 YPG
MarShawn Lloyd	RB	349 YDS / 2 TD / 87.3 YPG / 8.9 YPC 4 REC / 67 REC YDS / 0 REC TD / 16.8 REC YPG
Solomon Byrd	DE	9 TKL / 2.0 TFL / 4.5 SACK
Jaylin Smith	S	20 TKL / 3.0 TFL
Jamil Muhammad	DE	8 TKL / 2.0 TFL / 3.0 SACK
Romello Height	DE	5 TKL / 3.0 TFL / 2.0 SACK

Colorado 2023 Key Players

Name	Position	Stats
Shedeur Sanders	QB	1,410 YDS (76.9%) / 11 TD / 1 INT -93 RUSH YDS / 1 RUSH TD / -23.3 RUSH YPG
Xavier Weaver	WR	34 REC / 461 YDS / 2 TD / 115.3 YPG
Dylan Edwards	RB	157 YDS / 1 TD / 39.3 YPG / 5.6 YPC 17 REC / 169 REC YDS / 3 REC TD / 42.3 REC YPG
Jimmy Horn Jr.	WR	27 REC / 243 YDS / 2 TD / 60.8 YPG
Trevor Woods	S	25 TKL / 0.0 TFL / 2 INT / 3 PD
Shilo Sanders	S	26 TKL / 0.0 TFL / 1 INT / 1 PD
Cam'Ron Silmon	S	17 TKL / 1.0 TFL / 1.0 SACK / 2 INT
Jordan Domineck	OLB	15 TKL / 5.0 TFL / 2.0 SACK