South Florida vs. UAB Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

FOX Sports

The South Florida Bulls (7-3) are 21.5-point favorites when they visit the UAB Blazers (3-7) in an AAC matchup on Saturday, November 22, 2025 at Protective Stadium. The over/under is 68.5.

In their last action, the Bulls lost versus the Navy Midshipmen, 41-38. In their last game, the Blazers lost versus the North Texas Mean Green, 53-24.

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South Florida vs. UAB Game Information & Odds

When: Saturday, November 22, 2025 at 3 p.m. ET
Location: Protective Stadium in Birmingham, Alabama
TV: ESPN+
Live Box Score on FOX Sports

South Florida vs UAB Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
South Florida	-21.5 (-111)	-1923	+1025	68.5	-109	-111

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South Florida vs. UAB Prediction

Pick ATS: South Florida (-21.5)
Pick OU: Under (68.5)
Prediction: South Florida 45, UAB 20

Predictions are made by the Data Skrive betting model.

Learn more about the South Florida Bulls vs. the UAB Blazers game on FOX Sports!

South Florida vs. UAB Betting Insights

Per the spread and over/under, the implied score for the matchup is Bulls 45, Blazers 24.
The Bulls have a 95.1% chance to collect the win in this game based on the moneyline's implied probability. The Blazers have an 8.9% implied probability.
South Florida has put together a 6-3-1 record against the spread this season.
UAB is 3-7-0 ATS this season.

South Florida vs. UAB: Head-to-Head

South Florida and UAB have been evenly matched over their last two games, sharing the same 1-1 record.
In those games versus South Florida, the Blazers have covered two times while eclipsing the total both times.
In their last two head-to-head matchups, UAB has racked up 81 points versus South Florida, while allowing only 70 points.

South Florida vs. UAB: 2025 Stats Comparison

	South Florida	UAB
Off. Points per Game (Rank)	41.6 (5)	26.8 (75)
Def. Points per Game (Rank)	25.9 (76)	38.7 (134)
Turnovers Allowed (Rank)	14 (79)	17 (111)
Turnovers Forced (Rank)	20 (8)	5 (134)

South Florida 2025 Key Players

Name	Position	Stats
Byrum Brown	QB	2,530 YDS (65.4%) / 21 TD / 7 INT 841 RUSH YDS / 11 RUSH TD / 84.1 RUSH YPG
Keshaun Singleton	WR	38 REC / 659 YDS / 6 TD / 65.9 YPG
Jeremiah Koger	WR	28 REC / 467 YDS / 6 TD / 58.4 YPG
Nykahi Davenport	RB	425 YDS / 5 TD / 53.1 YPG / 6.7 YPC 2 REC / 22 REC YDS / 0 REC TD / 11 REC YPG
Mac Harris	LB	84 TKL / 5 TFL / 6 SACK / 1 INT
Jhalyn Shuler	LB	78 TKL / 4 TFL / 1.5 SACK / 1 INT
Jarvis Lee Jr.	DB	37 TKL / 7 TFL / 3 SACK / 2 INT
Tavin Ward	DB	55 TKL / 0 TFL / 1 INT / 1 PD

UAB 2025 Key Players

Name	Position	Stats
Jevon Jackson	RB	751 YDS / 3 TD / 75.1 YPG / 5.9 YPC 17 REC / 115 REC YDS / 1 REC TD / 16.4 REC YPG
Iverson Hooks	WR	57 REC / 735 YDS / 6 TD / 73.5 YPG
Jalen Kitna	QB	2,066 YDS (66.8%) / 11 TD / 7 INT
Solomon Beebe	RB	277 YDS / 5 TD / 27.7 YPG / 7.1 YPC 29 REC / 269 REC YDS / 0 REC TD / 26.9 REC YPG
Devin Hightower	LB	50 TKL / 1 TFL / 1 INT / 1 PD
Eamon Smalls	DL	35 TKL / 4 TFL / 1 SACK
Pierre Royster	DB	30 TKL / 0 TFL / 2 INT / 2 PD
Chris Burge	DL	22 TKL / 2 TFL / 2.5 SACK