South Carolina vs. Coastal Carolina Prediction, Odds, Picks - November 22, 2025

South Carolina vs. Coastal Carolina Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET
Data Skrive

The Coastal Carolina Chanticleers (6-4) are overwhelming 23.5-point underdogs on Saturday, November 22, 2025 against the South Carolina Gamecocks (3-7). A 50-point over/under is set for the game.

In their last game, the Gamecocks lost against the Texas A&M Aggies, 31-30. Last time around, the Chanticleers fell to the Georgia Southern Eagles, with 45-40 being the final score.

Keep up with college football all season on FOX Sports.

South Carolina vs. Coastal Carolina Game Information & Odds

  • When: Saturday, November 22, 2025 at 4:15 p.m. ET
  • Location: Williams-Brice Stadium in Columbia, South Carolina
  • TV: SEC Network
  • Live Box Score on FOX Sports
South Carolina vs Coastal Carolina Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite Spread (Odds) Favorite Moneyline Underdog Moneyline Total Over Moneyline Under Moneyline
South Carolina -23.5 (-124) -3030 +1325 50 -111 -110

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South Carolina vs. Coastal Carolina Prediction

  • Pick ATS: Coastal Carolina (+23.5)
  • Pick OU: Over (50)
  • Prediction: South Carolina 34, Coastal Carolina 18

Predictions are made by the Data Skrive betting model.

Learn more about the South Carolina Gamecocks vs. the Coastal Carolina Chanticleers game on FOX Sports!

South Carolina vs. Coastal Carolina Betting Insights

  • Per the spread and over/under, the implied score for the matchup is Gamecocks 37, Chanticleers 13.
  • The Gamecocks have a 96.8% chance to claim victory in this game based on the moneyline's implied probability. The Chanticleers have a 7.0% implied probability.
  • South Carolina has won five games against the spread this season, while failing to cover five times.
  • Coastal Carolina has won five games against the spread this year, failing to cover five times.

South Carolina vs. Coastal Carolina: 2025 Stats Comparison

South Carolina Coastal Carolina
Off. Points per Game (Rank) 20.7 (117) 25.7 (86)
Def. Points per Game (Rank) 23 (48) 29.7 (98)
Turnovers Allowed (Rank) 13 (69) 16 (104)
Turnovers Forced (Rank) 19 (13) 18 (20)

South Carolina 2025 Key Players

Name Position Stats
LaNorris Sellers QB 1,782 YDS (60.2%) / 9 TD / 6 INT
186 RUSH YDS / 3 RUSH TD / 18.6 RUSH YPG
Nyck Harbor WR 24 REC / 503 YDS / 5 TD / 50.3 YPG
Rahsul Faison RB 376 YDS / 3 TD / 37.6 YPG / 4.4 YPC
18 REC / 106 REC YDS / 0 REC TD / 11.8 REC YPG
Vandrevius Jacobs WR 25 REC / 407 YDS / 3 TD / 45.2 YPG
Bryan Thomas Jr. DL 30 TKL / 7 TFL / 6 SACK
Dylan Stewart DL 30 TKL / 10 TFL / 5 SACK
Fred Johnson LB 45 TKL / 4 TFL / 1 SACK / 1 INT
DQ Smith DB 51 TKL / 1 TFL / 1 INT / 1 PD

Coastal Carolina 2025 Key Players

Name Position Stats
Samari Collier QB 489 YDS (48.7%) / 7 TD / 2 INT
429 RUSH YDS / 7 RUSH TD / 53.6 RUSH YPG
Ja'Vin Simpkins RB 536 YDS / 2 TD / 53.6 YPG / 5.3 YPC
Dominic Knicely RB 364 YDS / 3 TD / 36.4 YPG / 6.3 YPC
Robby Washington WR 20 REC / 201 YDS / 2 TD / 22.3 YPG
Xamarion Gordon DB 46 TKL / 2 TFL / 2 INT / 2 PD
Ezekiel Durham-Campbell DL 26 TKL / 3 TFL / 5.5 SACK
Tray Brown LB 30 TKL / 7 TFL / 2.5 SACK
Dontae Lunan LB 27 TKL / 5 TFL / 1 INT / 1 PD

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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