South Carolina vs. Coastal Carolina Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

The Coastal Carolina Chanticleers (6-4) are overwhelming 23.5-point underdogs on Saturday, November 22, 2025 against the South Carolina Gamecocks (3-7). A 50-point over/under is set for the game.

In their last game, the Gamecocks lost against the Texas A&M Aggies, 31-30. Last time around, the Chanticleers fell to the Georgia Southern Eagles, with 45-40 being the final score.

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South Carolina vs. Coastal Carolina Game Information & Odds

When: Saturday, November 22, 2025 at 4:15 p.m. ET
Location: Williams-Brice Stadium in Columbia, South Carolina
TV: SEC Network
Live Box Score on FOX Sports

South Carolina vs Coastal Carolina Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
South Carolina	-23.5 (-124)	-3030	+1325	50	-111	-110

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South Carolina vs. Coastal Carolina Prediction

Pick ATS: Coastal Carolina (+23.5)
Pick OU: Over (50)
Prediction: South Carolina 34, Coastal Carolina 18

Predictions are made by the Data Skrive betting model.

Learn more about the South Carolina Gamecocks vs. the Coastal Carolina Chanticleers game on FOX Sports!

South Carolina vs. Coastal Carolina Betting Insights

Per the spread and over/under, the implied score for the matchup is Gamecocks 37, Chanticleers 13.
The Gamecocks have a 96.8% chance to claim victory in this game based on the moneyline's implied probability. The Chanticleers have a 7.0% implied probability.
South Carolina has won five games against the spread this season, while failing to cover five times.
Coastal Carolina has won five games against the spread this year, failing to cover five times.

South Carolina vs. Coastal Carolina: 2025 Stats Comparison

	South Carolina	Coastal Carolina
Off. Points per Game (Rank)	20.7 (117)	25.7 (86)
Def. Points per Game (Rank)	23 (48)	29.7 (98)
Turnovers Allowed (Rank)	13 (69)	16 (104)
Turnovers Forced (Rank)	19 (13)	18 (20)

South Carolina 2025 Key Players

Name	Position	Stats
LaNorris Sellers	QB	1,782 YDS (60.2%) / 9 TD / 6 INT 186 RUSH YDS / 3 RUSH TD / 18.6 RUSH YPG
Nyck Harbor	WR	24 REC / 503 YDS / 5 TD / 50.3 YPG
Rahsul Faison	RB	376 YDS / 3 TD / 37.6 YPG / 4.4 YPC 18 REC / 106 REC YDS / 0 REC TD / 11.8 REC YPG
Vandrevius Jacobs	WR	25 REC / 407 YDS / 3 TD / 45.2 YPG
Bryan Thomas Jr.	DL	30 TKL / 7 TFL / 6 SACK
Dylan Stewart	DL	30 TKL / 10 TFL / 5 SACK
Fred Johnson	LB	45 TKL / 4 TFL / 1 SACK / 1 INT
DQ Smith	DB	51 TKL / 1 TFL / 1 INT / 1 PD

Coastal Carolina 2025 Key Players

Name	Position	Stats
Samari Collier	QB	489 YDS (48.7%) / 7 TD / 2 INT 429 RUSH YDS / 7 RUSH TD / 53.6 RUSH YPG
Ja'Vin Simpkins	RB	536 YDS / 2 TD / 53.6 YPG / 5.3 YPC
Dominic Knicely	RB	364 YDS / 3 TD / 36.4 YPG / 6.3 YPC
Robby Washington	WR	20 REC / 201 YDS / 2 TD / 22.3 YPG
Xamarion Gordon	DB	46 TKL / 2 TFL / 2 INT / 2 PD
Ezekiel Durham-Campbell	DL	26 TKL / 3 TFL / 5.5 SACK
Tray Brown	LB	30 TKL / 7 TFL / 2.5 SACK
Dontae Lunan	LB	27 TKL / 5 TFL / 1 INT / 1 PD