Ole Miss vs. Tulane Prediction, Odds, Picks - December 20, 2025

Updated Dec. 18, 2025 3:06 a.m. ET

Data Skrive

To start this year's College Football Playoff, the Ole Miss Rebels (11-1) will host the Tulane Green Wave (11-2) starting at 3:30 p.m. ET at Vaught-Hemingway Stadium in Oxford, Mississippi. Ole Miss is favored by 17.5 points. A total of 56.5 points has been set for this game.

The Rebels won against the Mississippi State Bulldogs in their last game, 38-19. Last time out, the Green Wave defeated the North Texas Mean Green, with 34-21 being the final score.

Keep up with college football all season on FOX Sports.

Ole Miss vs. Tulane Game Information & Odds

When: Saturday, December 20, 2025 at 3:30 p.m. ET
Location: Vaught-Hemingway Stadium in Oxford, Mississippi
TV: TNT
Live Box Score on FOX Sports

Ole Miss vs Tulane Betting Information updated as of December 18, 2025, 2:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ole Miss	-17.5 (-108)	-935	+612	56.5	-111	-109

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Ole Miss vs. Tulane Prediction

Pick ATS: Tulane (+17.5)
Pick OU: Under (56.5)
Prediction: Ole Miss 34, Tulane 21

Predictions are made by the Data Skrive betting model.

Learn more about the Ole Miss Rebels vs. the Tulane Green Wave game on FOX Sports!

Ole Miss vs. Tulane Betting Insights

Based on the spread and over/under, the implied score for the matchup is Rebels 37, Green Wave 20.
The Rebels have a 90.3% chance to win this game based on the moneyline's implied probability. The Green Wave hold a 14.0% implied probability.
Ole Miss is 7-5-0 ATS this season.
Tulane has won seven games against the spread this season, failing to cover six times.

Ole Miss vs. Tulane: Head-to-Head

Over their last three meetings, Ole Miss has totaled three wins versus Tulane.
The last three times the Rebels have matched up against the Green Wave, they have put up a 3-0 record against the spread. The scoring has gone over the point total on one occasion.
Over their last three head-to-head contests, Ole Miss has put up 143 points, while Tulane has compiled 51.

Ole Miss vs. Tulane: 2025 Stats Comparison

	Ole Miss	Tulane
Off. Points per Game (Rank)	37.3 (13)	29.1 (42)
Def. Points per Game (Rank)	20.1 (21)	22.6 (63)
Turnovers Allowed (Rank)	11 (16)	14 (49)
Turnovers Forced (Rank)	9 (120)	24 (10)

Ole Miss 2025 Key Players

Name	Position	Stats
Trinidad Chambliss	QB	3,016 YDS (65.5%) / 18 TD / 3 INT 470 RUSH YDS / 6 RUSH TD / 39.2 RUSH YPG
Kewan Lacy	RB	1,279 YDS / 20 TD / 106.6 YPG / 5 YPC 25 REC / 154 REC YDS / 0 REC TD / 14 REC YPG
Harrison Wallace III	WR	46 REC / 719 YDS / 3 TD / 59.9 YPG
De'Zhaun Stribling	WR	38 REC / 533 YDS / 5 TD / 44.4 YPG
Suntarine Perkins	LB	52 TKL / 4 TFL / 2 SACK / 1 INT
T.J. Dudley	LB	68 TKL / 2 TFL / 0.5 SACK
William Echoles	DL	45 TKL / 7 TFL / 4.5 SACK
Princewill Umanmielen	DL	32 TKL / 7 TFL / 6.5 SACK / 1 INT

Tulane 2025 Key Players

Name	Position	Stats
Jake Retzlaff	QB	2,862 YDS (62.4%) / 14 TD / 6 INT 610 RUSH YDS / 16 RUSH TD / 46.9 RUSH YPG
Javin Gordon	RB	505 YDS / 5 TD / 38.8 YPG / 4.1 YPC 13 REC / 93 REC YDS / 1 REC TD / 9.3 REC YPG
Shazz Preston	WR	38 REC / 598 YDS / 4 TD / 46 YPG
Anthony Brown	WR	35 REC / 466 YDS / 2 TD / 35.8 YPG
Jack Tchienchou	DB	65 TKL / 1 TFL / 1 SACK / 2 INT
Chris Rodgers	LB	61 TKL / 5 TFL / 2 SACK / 1 INT
Sam Howard	LB	36 TKL / 6 TFL / 4 SACK
Harvey Dyson III	LB	30 TKL / 7 TFL / 6 SACK