Ohio State vs. Illinois Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 9:04 a.m. ET

FOX Sports

The No. 1 Ohio State Buckeyes (5-0) will put their first-ranked scoring defense to the test against the No. 17 Illinois Fighting Illini (5-1) and the No. 25 scoring offense in college football, on Saturday, October 11, 2025. The Buckeyes are heavily favored by 14.5 points in the game. This game has an over/under of 50.5 points.

In their last game, the Buckeyes won against the Minnesota Golden Gophers, 42-3. The Fighting Illini beat the Purdue Boilermakers, 43-27, in their most recent contest.

Keep up with college football all season on FOX Sports.

Ohio State vs. Illinois Game Information & Odds

When: Saturday, October 11, 2025 at 12 p.m. ET
Location: Memorial Stadium (Champaign, IL) in Champaign, Illinois
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Ohio State vs Illinois Betting Information updated as of October 11, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio State	-14.5 (-111)	-699	+500	50.5	-111	-109

Ohio State vs. Illinois Prediction

Pick ATS: Illinois (+14.5)
Pick OU: Under (50.5)
Prediction: Illinois 26, Ohio State 23

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio State Buckeyes vs. the Illinois Fighting Illini game on FOX Sports!

Ohio State vs. Illinois Betting Insights

Per the spread and over/under, the implied score for the game is Buckeyes 32, Fighting Illini 18.
The Buckeyes have an 87.5% chance to collect the win in this game per the moneyline's implied probability. The Fighting Illini hold a 16.7% implied probability.
Ohio State has put together a 4-1-0 record against the spread this season.
Illinois has won five games against the spread this year, failing to cover once.

Ohio State vs. Illinois: 2025 Stats Comparison

	Ohio State	Illinois
Off. Points per Game (Rank)	37.4 (34)	37 (14)
Def. Points per Game (Rank)	5 (1)	24 (84)
Turnovers Allowed (Rank)	4 (18)	3 (9)
Turnovers Forced (Rank)	4 (106)	10 (15)

Ohio State 2025 Key Players

Name	Position	Stats
Julian Sayin	QB	1,313 YDS (80.2%) / 13 TD / 3 INT
Jeremiah Smith	WR	35 REC / 463 YDS / 6 TD / 92.6 YPG
Carnell Tate	WR	24 REC / 435 YDS / 4 TD / 87 YPG
CJ Donaldson	RB	193 YDS / 4 TD / 38.6 YPG / 4.3 YPC 4 REC / 26 REC YDS / 1 REC TD / 8.7 REC YPG
Caden Curry	DL	28 TKL / 8 TFL / 5 SACK
Kayden McDonald	DL	23 TKL / 5 TFL / 3 SACK
Arvell Reese	LB	29 TKL / 3 TFL / 3 SACK
Sonny Styles	LB	29 TKL / 1 TFL

Illinois 2025 Key Players

Name	Position	Stats
Luke Altmyer	QB	1,573 YDS (73.6%) / 12 TD / 0 INT -8 RUSH YDS / 2 RUSH TD / -1.3 RUSH YPG
Hank Beatty	WR	32 REC / 569 YDS / 2 TD / 94.8 YPG
Kaden Feagin	RB	316 YDS / 5 TD / 52.7 YPG / 4 YPC 8 REC / 100 REC YDS / 1 REC TD / 25 REC YPG
Ca'Lil Valentine	RB	323 YDS / 3 TD / 53.8 YPG / 5.3 YPC
Gabe Jacas	LB	16 TKL / 1 TFL / 4.5 SACK
Matthew Bailey	DB	26 TKL / 0 TFL
Dylan Rosiek	LB	19 TKL / 2 TFL / 1 INT / 1 PD
Leon Lowery	LB	13 TKL / 3 TFL / 2 SACK