Notre Dame vs. Stanford Prediction, Odds, Picks - November 29, 2025

The No. 9 Notre Dame Fighting Irish (9-2), who have college football's 12th-ranked rush defense, take on the Stanford Cardinal (4-7) and their 25th-ranked rushing defense on Saturday, November 29, 2025. The Fighting Irish are double-digit, 31.5-point favorites. The game's point total is set at 49.5.

Facing the Syracuse Orange in their last game, the Fighting Irish won 70-7. The Cardinal won against the California Golden Bears in their last game, 31-10.

Keep up with college football all season on FOX Sports.

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Joel Klatt analyzed if the Notre Dame Fighting Irish should be ranked ahead of the Alabama Crimson Tide. He explained why the committee is using the eye test over the resume when evaluating teams.

Notre Dame vs. Stanford Game Information & Odds

• When: Saturday, November 29, 2025 at 10:30 p.m. ET
• Location: Stanford Stadium in Stanford, California
• TV: ESPN
• Live Box Score on FOX Sports

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Notre Dame vs. Stanford Prediction

• Pick ATS: Stanford (+31.5)
  
• Pick OU: Over (49.5)
  
• Prediction: Notre Dame 40, Stanford 12

Predictions are made by the Data Skrive betting model.

Learn more about the Notre Dame Fighting Irish vs. the Stanford Cardinal game on FOX Sports!

Notre Dame vs. Stanford Betting Insights

• Per the spread and over/under, the implied score for the matchup is Fighting Irish 40, Cardinal 9.
• The Fighting Irish have a 99.1% chance to collect the win in this contest per the moneyline's implied probability. The Cardinal have a 3.9% implied probability.
• Notre Dame is 6-5-0 ATS this season.
• Stanford has covered four times in 11 matchups with a spread this season.

Notre Dame vs. Stanford: Head-to-Head

• Notre Dame has a 2-1 record against Stanford in their last three matchups.
• The last three times the Fighting Irish have played the Cardinal, they have a 2-1 record against the spread. The scoring has gone over the point total on two occasions.
• Over their last three head-to-head contests, Notre Dame has racked up 119 points, while Stanford has posted 46.

Notre Dame vs. Stanford: 2025 Stats Comparison

Notre Dame 2025 Key Players

Stanford 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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