Notre Dame vs. Stanford Prediction, Odds, Picks - November 29, 2025

Updated Nov. 29, 2025 9:04 p.m. ET

FOX Sports

The No. 9 Notre Dame Fighting Irish (9-2), who have college football's 12th-ranked rush defense, take on the Stanford Cardinal (4-7) and their 25th-ranked rushing defense on Saturday, November 29, 2025. The Fighting Irish are double-digit, 31.5-point favorites. The game's point total is set at 49.5.

Facing the Syracuse Orange in their last game, the Fighting Irish won 70-7. The Cardinal won against the California Golden Bears in their last game, 31-10.

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Notre Dame vs. Stanford Game Information & Odds

When: Saturday, November 29, 2025 at 10:30 p.m. ET
Location: Stanford Stadium in Stanford, California
TV: ESPN
Live Box Score on FOX Sports

Notre Dame vs Stanford Betting Information updated as of November 29, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Notre Dame	-31.5 (-115)	-11111	+2460	49.5	-111	-109

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Notre Dame vs. Stanford Prediction

Pick ATS: Stanford (+31.5)
Pick OU: Over (49.5)
Prediction: Notre Dame 40, Stanford 12

Predictions are made by the Data Skrive betting model.

Learn more about the Notre Dame Fighting Irish vs. the Stanford Cardinal game on FOX Sports!

Notre Dame vs. Stanford Betting Insights

Per the spread and over/under, the implied score for the matchup is Fighting Irish 40, Cardinal 9.
The Fighting Irish have a 99.1% chance to collect the win in this contest per the moneyline's implied probability. The Cardinal have a 3.9% implied probability.
Notre Dame is 6-5-0 ATS this season.
Stanford has covered four times in 11 matchups with a spread this season.

Notre Dame vs. Stanford: Head-to-Head

Notre Dame has a 2-1 record against Stanford in their last three matchups.
The last three times the Fighting Irish have played the Cardinal, they have a 2-1 record against the spread. The scoring has gone over the point total on two occasions.
Over their last three head-to-head contests, Notre Dame has racked up 119 points, while Stanford has posted 46.

Notre Dame vs. Stanford: 2025 Stats Comparison

	Notre Dame	Stanford
Off. Points per Game (Rank)	41.4 (8)	18.7 (127)
Def. Points per Game (Rank)	17.4 (11)	27.4 (79)
Turnovers Allowed (Rank)	10 (11)	16 (80)
Turnovers Forced (Rank)	22 (9)	13 (85)

Notre Dame 2025 Key Players

Name	Position	Stats
Jeremiyah Love	RB	1,306 YDS / 17 TD / 118.7 YPG / 7.1 YPC 26 REC / 274 REC YDS / 3 REC TD / 27.4 REC YPG
CJ Carr	QB	2,536 YDS (66.9%) / 22 TD / 6 INT 18 RUSH YDS / 3 RUSH TD / 1.6 RUSH YPG
Jadarian Price	RB	659 YDS / 10 TD / 59.9 YPG / 6.2 YPC 3 REC / 47 REC YDS / 1 REC TD / 11.8 REC YPG
Malachi Fields	WR	33 REC / 608 YDS / 5 TD / 55.3 YPG
Boubacar Traore	DL	35 TKL / 9 TFL / 6.5 SACK
Kyngstonn Viliamu-Asa	LB	39 TKL / 5 TFL / 3 SACK / 1 INT
Drayk Bowen	LB	49 TKL / 2 TFL / 3 SACK
Adon Shuler	DB	41 TKL / 2 TFL / 1 SACK / 2 INT

Stanford 2025 Key Players

Name	Position	Stats
CJ Williams	WR	58 REC / 735 YDS / 6 TD / 66.8 YPG
Micah Ford	RB	643 YDS / 4 TD / 71.4 YPG / 4.4 YPC 11 REC / 119 REC YDS / 0 REC TD / 17 REC YPG
Ben Gulbranson	QB	1,813 YDS (56.9%) / 9 TD / 10 INT
Cole Tabb	RB	402 YDS / 3 TD / 40.2 YPG / 3.9 YPC
Matt Rose	LB	74 TKL / 5 TFL / 3 SACK
Jahsiah Galvan	LB	42 TKL / 2 TFL
Clay Patterson	DL	24 TKL / 2 TFL / 4 SACK
Scotty Edwards	DB	29 TKL / 3 TFL / 2.5 SACK