Nebraska vs. Northwestern Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 9:04 a.m. ET

Data Skrive

The Nebraska Cornhuskers (5-2) bring the 18th-ranked passing attack in college football into a matchup with the Northwestern Wildcats (5-2), who have the No. 17 passing defense, on Saturday, October 25, 2025. The Cornhuskers are 7.5-point favorites. The point total is set at 44.5 for the game.

Against the Minnesota Golden Gophers in their last game, the Cornhuskers lost 24-6. The Wildcats won versus the Purdue Boilermakers in their most recent game, 19-0.

Keep up with college football all season on FOX Sports.

Nebraska vs. Northwestern Game Information & Odds

When: Saturday, October 25, 2025 at 12 p.m. ET
Location: Memorial Stadium (Lincoln, NE) in Lincoln, Nebraska
TV: FS1
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Nebraska vs Northwestern Betting Information updated as of October 25, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Nebraska	-7.5 (-104)	-292	+234	44.5	-109	-110

Nebraska vs. Northwestern Prediction

Pick ATS: Northwestern (+7.5)
Pick OU: Over (44.5)
Prediction: Nebraska 24, Northwestern 21

Predictions are made by the Data Skrive betting model.

Learn more about the Nebraska Cornhuskers vs. the Northwestern Wildcats game on FOX Sports!

Nebraska vs. Northwestern Betting Insights

Per the spread and over/under, the implied score for the tilt is Cornhuskers 26, Wildcats 18.
The Cornhuskers have a 74.5% chance to claim victory in this meeting based on the moneyline's implied probability. The Wildcats hold a 29.9% implied probability.
Nebraska has a record of 2-5-0 against the spread this season.
Northwestern has put together a 5-2-0 ATS record so far this season.

Nebraska vs. Northwestern: Head-to-Head

Nebraska owns a 2-1 record against Northwestern in their last three matchups.
The last three times the Wildcats have played the Cornhuskers, they have a 2-1 record against the spread. The scoring has gone over the total on two occasions.
Northwestern has been outscored by 54 points in its last three tilts against Nebraska.

Nebraska vs. Northwestern: 2025 Stats Comparison

	Nebraska	Northwestern
Off. Points per Game (Rank)	36 (28)	22.7 (102)
Def. Points per Game (Rank)	19.4 (33)	15.1 (12)
Turnovers Allowed (Rank)	6 (21)	11 (104)
Turnovers Forced (Rank)	9 (56)	7 (89)

Nebraska 2025 Key Players

Name	Position	Stats
Emmett Johnson	RB	713 YDS / 7 TD / 101.9 YPG / 6 YPC 29 REC / 167 REC YDS / 1 REC TD / 23.9 REC YPG
Dylan Raiola	QB	1,770 YDS (72.8%) / 16 TD / 5 INT
Nyziah Hunter	WR	27 REC / 455 YDS / 4 TD / 65 YPG
Jacory Barney Jr.	WR	27 REC / 365 YDS / 3 TD / 52.1 YPG
Javin Wright	LB	50 TKL / 5 TFL / 0.5 SACK
DeShon Singleton	DB	29 TKL / 0 TFL / 2 INT / 2 PD
Williams Nwaneri	DL	19 TKL / 2 TFL / 1.5 SACK
Vincent Shavers Jr.	LB	23 TKL / 4 TFL

Northwestern 2025 Key Players

Name	Position	Stats
Caleb Komolafe	RB	483 YDS / 5 TD / 69 YPG / 4.5 YPC
Griffin Wilde	WR	36 REC / 516 YDS / 4 TD / 73.7 YPG
Preston Stone	QB	1,213 YDS (59.4%) / 10 TD / 7 INT
Joseph Himon II	RB	360 YDS / 0 TD / 51.4 YPG / 4.9 YPC 15 REC / 103 REC YDS / 0 REC TD / 14.7 REC YPG
Mac Uihlein	LB	51 TKL / 4 TFL / 3 INT / 3 PD
Robert Fitzgerald	DB	59 TKL / 2 TFL
Michael Kilbane	DL	18 TKL / 3 TFL / 2.5 SACK
Braydon Brus	LB	30 TKL / 1 TFL / 0.5 SACK