Michigan vs. Michigan State Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 3:04 p.m. ET

Data Skrive

The No. 25 Michigan Wolverines (5-2) and the Michigan State Spartans (3-4) take the field with the Paul Bunyan Trophy on the line on Saturday, October 25, 2025 at Spartan Stadium. The Wolverines are heavily favored by 14 points in the game. The total is 47.5 points for this game.

In their last action, the Wolverines won against the Washington Huskies, 24-7. Facing the Indiana Hoosiers in their last game, the Spartans lost 38-13.

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Michigan vs. Michigan State Game Information & Odds

When: Saturday, October 25, 2025 at 7:30 p.m. ET
Location: Spartan Stadium in East Lansing, Michigan
TV: NBC
Live Box Score on FOX Sports

Michigan vs Michigan State Betting Information updated as of October 25, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Michigan	-14 (-111)	-581	+426	47.5	-109	-111

Michigan vs. Michigan State Prediction

Pick ATS: Michigan (-14)
Pick OU: Over (47.5)
Prediction: Michigan 35, Michigan State 18

Predictions are made by the Data Skrive betting model.

Learn more about the Michigan Wolverines vs. the Michigan State Spartans game on FOX Sports!

Michigan vs. Michigan State Betting Insights

Based on the spread and over/under, the implied score for the matchup is Wolverines 31, Spartans 17.
The Wolverines have an 85.3% chance to win this meeting per the moneyline's implied probability. The Spartans hold a 19.0% implied probability.
Michigan has compiled a 3-4-0 ATS record so far this year.
Michigan State has won three games against the spread this season, failing to cover four times.

Michigan vs. Michigan State: Head-to-Head

Over their last four meetings, Michigan has put up three wins against Michigan State.
In their last four head-to-head meetings, each team has covered two times with those contests outscoring the point total on three occasions.
Michigan State has been outpaced by 74 points in its last four tilts against Michigan.

Michigan vs. Michigan State: 2025 Stats Comparison

	Michigan	Michigan State
Off. Points per Game (Rank)	28.7 (70)	27.1 (79)
Def. Points per Game (Rank)	17 (17)	32.7 (118)
Turnovers Allowed (Rank)	5 (12)	8 (56)
Turnovers Forced (Rank)	14 (10)	5 (116)

Michigan 2025 Key Players

Name	Position	Stats
Justice Haynes	RB	705 YDS / 8 TD / 117.5 YPG / 7.4 YPC
Bryce Underwood	QB	1,440 YDS (62.4%) / 7 TD / 2 INT 202 RUSH YDS / 3 RUSH TD / 28.9 RUSH YPG
Jordan Marshall	RB	434 YDS / 4 TD / 62 YPG / 5.2 YPC 6 REC / 49 REC YDS / 0 REC TD / 12.3 REC YPG
Donaven McCulley	WR	24 REC / 369 YDS / 2 TD / 52.7 YPG
Cole Sullivan	LB	19 TKL / 4 TFL / 2 SACK / 3 INT
Derrick Moore	DL	12 TKL / 3 TFL / 4.5 SACK
Jimmy Rolder	LB	32 TKL / 2 TFL / 1 SACK / 1 INT
Jaishawn Barham	LB	18 TKL / 5 TFL / 3 SACK

Michigan State 2025 Key Players

Name	Position	Stats
Aidan Chiles	QB	1,262 YDS (65.1%) / 10 TD / 3 INT 234 RUSH YDS / 5 RUSH TD / 33.4 RUSH YPG
Nick Marsh	WR	36 REC / 404 YDS / 5 TD / 57.7 YPG
Makhi Frazier	RB	384 YDS / 2 TD / 54.9 YPG / 4.1 YPC
Omari Kelly	WR	27 REC / 406 YDS / 1 TD / 58 YPG
Jordan Hall	LB	49 TKL / 3 TFL / 2 SACK / 1 INT
Malik Spencer	DB	29 TKL / 3 TFL / 2 SACK
Wayne Matthews III	LB	40 TKL / 1 TFL / 1 INT / 1 PD
Armorion Smith	DB	26 TKL / 1 TFL / 1 INT / 1 PD