Iowa State vs. Colorado Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 3:05 p.m. ET

Data Skrive

The No. 22 Iowa State Cyclones (5-1) visit the Colorado Buffaloes (2-4) on Saturday, October 11, 2025 in a matchup between Big 12 foes at Folsom Field. Colorado is a 3-point underdog. The over/under is 52 for this game.

The Cyclones lost to the Cincinnati Bearcats, 38-30, in their most recent contest. Against the TCU Horned Frogs in their last game, the Buffaloes lost 35-21.

Keep up with college football all season on FOX Sports.

Iowa State vs. Colorado Game Information & Odds

When: Saturday, October 11, 2025 at 3:30 p.m. ET
Location: Folsom Field in Boulder, Colorado
TV: ESPN
Live Box Score on FOX Sports

Iowa State vs Colorado Betting Information updated as of October 11, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Iowa State	-3 (-110)	-152	+128	52	-110	-110

Iowa State vs. Colorado Prediction

Pick ATS: Iowa State (-3)
Pick OU: Under (52)
Prediction: Iowa State 28, Colorado 20

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa State Cyclones vs. the Colorado Buffaloes game on FOX Sports!

Iowa State vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the matchup is Cyclones 28, Buffaloes 24.
The Cyclones have a 60.3% chance to claim victory in this game based on the moneyline's implied probability. The Buffaloes hold a 43.9% implied probability.
Iowa State has compiled a 3-2-1 ATS record so far this year.
Colorado has compiled a 3-3-0 ATS record so far this season.

Iowa State vs. Colorado: 2025 Stats Comparison

	Iowa State	Colorado
Off. Points per Game (Rank)	31.3 (33)	25 (69)
Def. Points per Game (Rank)	18.2 (49)	24.8 (91)
Turnovers Allowed (Rank)	5 (35)	8 (93)
Turnovers Forced (Rank)	9 (22)	5 (89)

Iowa State 2025 Key Players

Name	Position	Stats
Rocco Becht	QB	1,417 YDS (64.9%) / 9 TD / 2 INT 55 RUSH YDS / 7 RUSH TD / 9.2 RUSH YPG
Carson Hansen	RB	348 YDS / 2 TD / 58 YPG / 4.4 YPC 11 REC / 88 REC YDS / 0 REC TD / 14.7 REC YPG
Brett Eskildsen	WR	18 REC / 321 YDS / 2 TD / 53.5 YPG
Abu Sama III	RB	304 YDS / 2 TD / 50.7 YPG / 4.5 YPC
Marcus Neal	DB	35 TKL / 5 TFL / 1 SACK
Jamison Patton	DB	27 TKL / 0 TFL / 2 INT / 2 PD
Kooper Ebel	LB	23 TKL / 1 TFL / 1 SACK
Caleb Bacon	LB	22 TKL / 3 TFL

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	901 YDS (65.8%) / 7 TD / 4 INT 214 RUSH YDS / 5 RUSH TD / 42.8 RUSH YPG
Omarion Miller	WR	17 REC / 289 YDS / 3 TD / 57.8 YPG
Joseph Williams	WR	16 REC / 242 YDS / 2 TD / 40.3 YPG
Sincere Brown	WR	9 REC / 228 YDS / 2 TD / 38 YPG
Keaten Wade	DL	19 TKL / 4 TFL / 2.5 SACK
Martavius French	LB	13 TKL / 2 TFL / 1 SACK
Jeremiah Brown	LB	20 TKL / 2 TFL
Tawfiq Byard	DB	23 TKL / 1 TFL / 0.5 SACK