Penn State vs. Pittsburgh Prediction, How to Watch, Odds, Channel - Dec 21

Updated Dec. 21, 2025 10:28 a.m. ET

Data Skrive

The Penn State Nittany Lions (8-3) take on the Pittsburgh Panthers (6-6) on Sunday, December 21, 2025 at 12 p.m. ET on Big Ten Network.

The Nittany Lions are a slight 1.5-point favorite against the Panthers. The over/under for the matchup is set at 147.5.

Continue reading to get the details before betting on the Penn State-Pittsburgh matchup.

Penn State vs. Pittsburgh How to Watch & Odds

When: Sunday, December 21, 2025 at 12 p.m. ET
Where: GIANT Center in Hershey, Pennsylvania
TV: Big Ten Network
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Nittany Lions vs Panthers Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Nittany Lions	-1.5	102	-122	147.5	-108	-112	-110	-110

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Penn State vs. Pittsburgh Prediction

Pick ATS: Pittsburgh (+1.5)
Pick OU: Over (147.5)
Prediction: Penn State 75, Pittsburgh 74

Learn more about the Penn State Nittany Lions vs. the Pittsburgh Panthers game on FOX Sports!

Penn State vs. Pittsburgh Betting Insights

Betting Line Implied Predictions

Based on the spread and over/under, the implied score for the encounter is Nittany Lions 74, Panthers 73.
The Nittany Lions have a 52.4% chance to collect the win in this matchup based on the moneyline's implied probability.
The Panthers hold a 52.4% implied probability to come out on top.

Key Spread Facts

Penn State has won four games against the spread this season, while failing to cover seven times.
Pittsburgh has put together a 5-7-0 record against the spread this season.
Penn State has covered the spread three times this season (3-5 ATS) when playing as at least 1.5-point favorites.
Pittsburgh has been an underdog by 1.5 points or more four times this year, and covered the spread in one of those games.

Key Total Facts

The Nittany Lions and their opponent have broken the 147.5-point mark eight times this year.
Panthers games have had over 147.5 points four times this year.
The Nittany Lions and Panthers average 154.6 points per game combined, which is 7.1 more than the over/under for this matchup.

Key Moneyline Facts

Penn State has not lost as the moneyline favorite this season, going 8-0.
Pittsburgh has entered the game as underdogs four times this season and won once.
Penn State has won all eight games it played as a moneyline favorite with odds of -110 or shorter.
This season, Pittsburgh has won one of its four games when it is the underdog by at least -110 on the moneyline.

Penn State vs. Pittsburgh: 2025-26 Stats Comparison

	Penn State	Pittsburgh
Points Scored Per Game (Rank)	81.1 (108)	73.5 (273)
Points Allowed (Rank)	74.5 (210)	69.6 (95)
Rebounds (Rank)	8.3 (288)	10.4 (114)
3pt Made (Rank)	7.1 (260)	8.5 (133)
Assists (Rank)	14.1 (209)	13.2 (266)
Turnovers (Rank)	8.7 (6)	11.3 (154)

Penn State 2025-26 Key Players

Nittany Lions Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Kayden Mingo	11	15	4.1	4.4	2.1	0.1	0.6
Freddie Filione V	11	14.2	3.4	2.4	1.3	0.1	1.4
Melih Tunca	11	12.1	2.7	3.2	0.9	0.4	1.1
Ivan Jurić	11	9.7	4.1	0.5	0.3	0.3	0.5
Josh Reed	11	9.5	4.1	1	1.2	0.1	0.5

Pittsburgh 2025-26 Key Players

Panthers Leaders
Name	GP	PTS	REB	ASST	STL	BLK	3PM
Cameron Corhen	12	13.5	8.7	1.9	0.9	0.8	0.5
Brandin Cummings	9	13.2	1.2	2.2	0.7	0.1	1.9
Barry Dunning Jr.	12	12.8	4.9	0.7	0.5	1.3	2
Damarco Minor	12	10.4	4	3.3	1.5	0.3	1.8
Nojus Indrusaitis	12	9.7	3.1	1.7	0.9	0.2	1.6