Michigan State vs. Detroit Mercy Prediction, How to Watch, Odds, Channel - Nov 21

The No. 17 Michigan State Spartans (4-0) hope to continue a four-game winning streak when they host the Detroit Mercy Titans (1-4) at 6:30 p.m. ET on Friday, November 21, 2025 at Jack Breslin Students Events Center. The game airs on Big Ten Network.

The Spartans are a huge favorite against the Titans when the Spartans and the Titans meet. The Spartans are favored by 30.5 points. The matchup features an over/under of 152.5.

Keep scrolling to get the details ahead of placing bets on the Michigan State-Detroit Mercy clash.

Michigan State vs. Detroit Mercy How to Watch & Odds

• When: Friday, November 21, 2025 at 6:30 p.m. ET
• Where: Jack Breslin Students Events Center in East Lansing, Michigan
• TV: Big Ten Network
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

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Michigan State vs. Detroit Mercy Prediction

• Pick ATS: Detroit Mercy (+30.5)
  
• Pick OU: Under (152.5)
  
• Prediction: Michigan State 89, Detroit Mercy 62

Learn more about the Michigan State Spartans vs. the Detroit Mercy Titans game on FOX Sports!

Michigan State vs. Detroit Mercy Betting Insights

Betting Line Implied Predictions

• Based on the spread and over/under, the implied score for the matchup is Spartans 92, Titans 61.
• The Spartans have a 99.0% chance to claim victory in this contest based on the moneyline's implied probability.
• The Titans have a 2.9% implied probability to come out on top.

Key Spread Facts

• Michigan State went 24-13-0 ATS last season.
• Detroit Mercy has won one game against the spread this year.

Key Total Facts

• Spartans games finished with more than 152.5 points 11 times last year.
• There were 11 Titans games last season with more than 152.5 points scored.
• Last season, the two teams combined to average 7.7 points per game fewer than the total for this matchup (152.5).

Key Moneyline Facts

• Michigan State finished 25-4 in games it was listed as the moneyline favorite last season (winning 86.2% of those games).
• Detroit Mercy has been the underdog in three games this season, and it has failed to win any of those contests.
• Michigan State played as a moneyline favorite of -10000 or shorter in just two games last season. They won both.
• Detroit Mercy has not entered a game this season with longer moneyline odds than +3300.

Michigan State vs. Detroit Mercy: 2024-25 Stats Comparison

Michigan State 2024-25 Top Performers

Detroit Mercy 2025-26 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Big Ten

Michigan State Spartans

Detroit Mercy Titans